Strain Name:
C57BL/6J-MtgxR3625Btlr/Mmmh
Stock Number:
040679-MU
Citation ID:
RRID:MMRRC_040679-MU
Other Names:
R3625 (G1), C57BL/6J-MtgxR3625Btlr
Major Collection:

Gene Information

Thy1
Name: thymus cell antigen 1, theta
Synonyms: Thy1.1, Thy 1.2, CD90, Thy1.2, Thy-1, T25, Thy-1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21838
Homologene: 4580
Cdh3
Name: cadherin 3
Synonyms: Cadp, Pcad, P-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 20464
VEGA: 10
Homologene: 3715
Prkd3
Name: protein kinase D3
Synonyms: 5730497N19Rik, PKD3, 4930557O20Rik, Prkcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: Kdm1, LSD1, 1810043O07Rik, Aof2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 99982
Homologene: 32240
Dab2ip
Name: disabled 2 interacting protein
Synonyms: 2310011D08Rik, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69601
Homologene: 13058
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Mms22l
Name: MMS22-like, DNA repair protein
Synonyms: F730047E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 212377
Homologene: 18874
Yeats4
Name: YEATS domain containing 4
Synonyms: NuBI-1, GAS41, B230215M10Rik, 4930573H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64050
VEGA: 10
Homologene: 4760
Rabgef1
Name: RAB guanine nucleotide exchange factor (GEF) 1
Synonyms: Ras negative regulator Rabex-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56715
Homologene: 8720
N4bp1
Name: NEDD4 binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 80750
Homologene: 23703
Rec8
Name: REC8 meiotic recombination protein
Synonyms: mrec, Rec8L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56739
Homologene: 3768
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224613
VEGA: 17
Homologene: 72130
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 545260
Homologene: 44428
Fbn2
Name: fibrillin 2
Synonyms: Sne, Fib-2, sy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Olfr1490
Name: olfactory receptor 1490
Synonyms: MOR266-6P, GA_x6K02T2RE5P-3987000-3987950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258098
Homologene: 79418
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: 1200014I03Rik, Factor XIIIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Acte1
Name: actin, epsilon 1
Synonyms: Gm498, LOC244239
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 102636989
Homologene: 131918
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384534
Homologene: 129605
Zfp36
Name: zinc finger protein 36
Synonyms: Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22695
Homologene: 2558
Prkcsh
Name: protein kinase C substrate 80K-H
Synonyms: 80K-H, hepatocystin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19089
VEGA: 9
HGNC: HGNC:9411
Homologene: 2056
Trim15
Name: tripartite motif-containing 15
Synonyms: 1810012B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 69097
Homologene: 23819
Gm2042
Name: predicted gene 2042
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 100039087
Homologene: 103830
Ifnab
Name: interferon alpha B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15974
HGNC: HGNC:5425
Homologene: 68536
Pogk
Name: pogo transposable element with KRAB domain
Synonyms: BASS2, 9130401E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71592
Homologene: 32346
Olfr672
Name: olfactory receptor 672
Synonyms: MOR32-4, GA_x6K02T2PBJ9-7625746-7624808
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258755
Homologene: 138317
Igsf8
Name: immunoglobulin superfamily, member 8
Synonyms: KCT-4, PGRL, PG regulatory-like protein, ESTM34, EWI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 140559
Homologene: 14163
Ube2z
Name: ubiquitin-conjugating enzyme E2Z
Synonyms: C030047H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268470
Homologene: 11319
Vmn1r6
Name: vomeronasal 1 receptor 6
Synonyms: V1rc20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171193
Homologene: 128340
Atg3
Name: autophagy related 3
Synonyms: APG3, PC3-96, 2610016C12Rik, Apg3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67841
Homologene: 6836
Pcdhb6
Name: protocadherin beta 6
Synonyms: Pcdhb5B, PcdhbF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93877
Homologene: 62177
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Vpreb1
Name: pre-B lymphocyte gene 1
Synonyms: CD179a, Vpreb-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22362
Homologene: 84741
Ociad2
Name: OCIA domain containing 2
Synonyms: 1810027I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 433904
Homologene: 78179
Nkx6-2
Name: NK6 homeobox 2
Synonyms: Nkx6.2, Gtx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14912
Homologene: 18580
Hist1h2bg
Name: histone cluster 1, H2bg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 319181
HGNC: HGNC:4757
Homologene: 136774
Grxcr2
Name: glutaredoxin, cysteine rich 2
Synonyms: LOC332309
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 332309
VEGA: 18
Homologene: 85304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 166,403,512 bp
  • T to C, chromosome 1 at 172,317,769 bp
  • C to A, chromosome 2 at 35,643,891 bp
  • A to G, chromosome 2 at 76,768,801 bp
  • T to A, chromosome 4 at 24,505,357 bp
  • A to T, chromosome 4 at 88,690,779 bp
  • T to C, chromosome 4 at 136,561,108 bp
  • C to T, chromosome 5 at 73,323,830 bp
  • T to C, chromosome 5 at 130,212,120 bp
  • C to T, chromosome 6 at 57,002,935 bp
  • A to T, chromosome 7 at 10,159,178 bp
  • C to A, chromosome 7 at 28,378,256 bp
  • A to T, chromosome 7 at 104,995,984 bp
  • A to G, chromosome 7 at 139,582,190 bp
  • T to C, chromosome 7 at 143,871,854 bp
  • A to G, chromosome 8 at 86,851,709 bp
  • C to A, chromosome 8 at 106,543,678 bp
  • A to G, chromosome 9 at 22,011,252 bp
  • A to G, chromosome 9 at 44,046,731 bp
  • A to G, chromosome 9 at 54,393,643 bp
  • A to T, chromosome 10 at 50,981,336 bp
  • T to C, chromosome 10 at 117,220,368 bp
  • A to G, chromosome 11 at 96,050,421 bp
  • T to C, chromosome 12 at 88,175,961 bp
  • T to C, chromosome 13 at 23,571,451 bp
  • T to G, chromosome 13 at 36,898,093 bp
  • T to C, chromosome 14 at 55,622,497 bp
  • G to C, chromosome 15 at 21,358,756 bp
  • T to C, chromosome 16 at 16,868,804 bp
  • C to T, chromosome 16 at 22,805,551 bp
  • T to A, chromosome 16 at 45,175,261 bp
  • T to C, chromosome 17 at 23,760,201 bp
  • T to C, chromosome 17 at 36,866,876 bp
  • C to T, chromosome 17 at 78,985,304 bp
  • G to T, chromosome 18 at 37,336,140 bp
  • T to A, chromosome 18 at 41,998,818 bp
  • T to C, chromosome 18 at 58,061,742 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • T to A, chromosome 19 at 13,654,982 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3625 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040679-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.