Strain Name:
C57BL/6J-MtgxR3715Btlr/Mmmh
Stock Number:
040708-MU
Citation ID:
RRID:MMRRC_040708-MU
Other Names:
R3715 (G1), C57BL/6J-MtgxR3715Btlr
Major Collection:

Gene Information

Elavl3
Name: ELAV like RNA binding protein 3
Synonyms: mHuC, Huc, 2600009P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15571
VEGA: 9
HGNC: HGNC:3314
Homologene: 31035
Shmt1
Name: serine hydroxymethyltransferase 1 (soluble)
Synonyms: mshmt2, mshmt1, mshmt, Shmt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20425
Homologene: 3074
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Rbfox2
Name: RNA binding protein, fox-1 homolog (C. elegans) 2
Synonyms: Fxh, 2810460A15Rik, Fbm2, Rbm9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 93686
VEGA: 15
HGNC: HGNC:9906
Homologene: 49375
Fam168a
Name: family with sequence similarity 168, member A
Synonyms: 2610030B18Rik, B930006L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319604
Homologene: 18702
Syncrip
Name: synaptotagmin binding, cytoplasmic RNA interacting protein
Synonyms: RRM RNA binding protein GRY-RBP, GRY-RBP, pp68, Nsap1l, Nsap1, 4632417O19Rik, 2610109K23Rik, hnRNP Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56403
Homologene: 4648
Mc4r
Name: melanocortin 4 receptor
Synonyms: Fatboy, Pkcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17202
VEGA: 18
HGNC: HGNC:6932
Homologene: 4320
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99526
Homologene: 34521
Aqr
Name: aquarius
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11834
Homologene: 7629
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Rps7
Name: ribosomal protein S7
Synonyms: S7, Mtu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20115
VEGA: 12
Homologene: 107159
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12294
Homologene: 74929
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77739
Homologene: 64642
Glt8d2
Name: glycosyltransferase 8 domain containing 2
Synonyms: 1110021D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74782
Homologene: 41826
Eaf1
Name: ELL associated factor 1
Synonyms: 4933403C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74427
VEGA: 14
Homologene: 12561
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329002
Homologene: 7198
Sbk1
Name: SH3-binding kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 104175
Homologene: 17084
Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms: PDC-E2, 6332404G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Tarsl2
Name: threonyl-tRNA synthetase-like 2
Synonyms: A530046H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272396
Homologene: 65036
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22787
Homologene: 48194
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Med17
Name: mediator complex subunit 17
Synonyms: C330002H14Rik, Trap80, Crsp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627537
Homologene: 129750
Tro
Name: trophinin
Synonyms: necdin and trophinin like, Tnn, trophinin-2, magphinin-gamma, magphinin-beta 2, magphinin-alpha, magphinin, Maged3l, Maged3, Trol
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 56191
Homologene: 75113
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Misshapen/NIKs-related kinase, MINK, Ysk2, Map4k6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50932
Homologene: 56762
Olfr1395
Name: olfactory receptor 1395
Synonyms: GA_x6K02T2QP88-6286247-6285294, MOR277-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258877
Homologene: 105890
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Arntl2
Name: aryl hydrocarbon receptor nuclear translocator-like 2
Synonyms: BMAL2, 4632430A05Rik, MOP9, bHLHe6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 272322
Homologene: 10609
Tdrd12
Name: tudor domain containing 12
Synonyms: 2410070K17Rik, G1-476-14, ecat8, 2410004F06Rik, EG434165, repro23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71981
Homologene: 87053
Sox30
Name: SRY (sex determining region Y)-box 30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 214105
Homologene: 34027
Abcd4
Name: ATP-binding cassette, sub-family D (ALD), member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Ube2q1
Name: ubiquitin-conjugating enzyme E2Q family member 1
Synonyms: 1110002C01Rik, PRO3094, NICE-5, 2310012M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70093
Homologene: 9730
Olfr1211
Name: olfactory receptor 1211
Synonyms: GA_x6K02T2Q125-50409367-50408432, MOR233-16P, MOR233-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258025
Homologene: 81548
Lipk
Name: lipase, family member K
Synonyms: Lipl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240633
VEGA: 19
Homologene: 75666
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 2010013I23Rik, 9130206N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103406
Homologene: 88124
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74464
Homologene: 18958
Xkr5
Name: X-linked Kx blood group related 5
Synonyms: 5430438H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319581
Homologene: 52219
Cers3
Name: ceramide synthase 3
Synonyms: T3L, related to TRH3, LOC233330, CerS3, 4930550L11Rik, Lass3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545975
Homologene: 18719
Lyg1
Name: lysozyme G-like 1
Synonyms: 2300002O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69541
Homologene: 18376
Tmem82
Name: transmembrane protein 82
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213989
Homologene: 27088
9930111J21Rik1
Name: RIKEN cDNA 9930111J21 gene 1
Synonyms: 9930111J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 667214
Homologene: 83188
Dexi
Name: dexamethasone-induced transcript
Synonyms: 1810029J14Rik, D16Bwg0586e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 58239
Homologene: 8517
Rnf217
Name: ring finger protein 217
Synonyms: Ibrdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268291
Homologene: 66368
Aaas
Name: achalasia, adrenocortical insufficiency, alacrimia
Synonyms: Aladin, GL003, D030041N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223921
VEGA: 15
Homologene: 9232
Gm10083
Name: predicted gene 10083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102639847
Epm2a
Name: epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
Synonyms: laforin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13853
HGNC: HGNC:3413
Homologene: 38087
Fam43b
Name: family with sequence similarity 43, member B
Synonyms: OTTMUSG00000009974
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 625638
Homologene: 45810
Olfr1184
Name: olfactory receptor 1184
Synonyms: GA_x6K02T2Q125-49974190-49975125, MOR225-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258820
Homologene: 73980
C130040N14Rik
Name: RIKEN cDNA C130040N14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619324
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 37,950,678 bp
  • G to A, chromosome 2 at 76,731,019 bp
  • C to T, chromosome 2 at 76,741,266 bp
  • C to A, chromosome 2 at 88,487,443 bp
  • A to G, chromosome 2 at 88,929,413 bp
  • A to G, chromosome 2 at 114,118,669 bp
  • T to C, chromosome 3 at 89,781,760 bp
  • T to C, chromosome 3 at 122,949,319 bp
  • A to T, chromosome 3 at 125,561,505 bp
  • T to A, chromosome 4 at 86,216,976 bp
  • A to G, chromosome 4 at 116,962,558 bp
  • G to C, chromosome 4 at 138,395,098 bp
  • A to T, chromosome 4 at 141,617,634 bp
  • T to A, chromosome 5 at 30,376,871 bp
  • T to C, chromosome 5 at 96,645,970 bp
  • A to G, chromosome 6 at 146,822,689 bp
  • T to C, chromosome 7 at 35,504,980 bp
  • G to A, chromosome 7 at 65,688,952 bp
  • G to T, chromosome 7 at 66,786,075 bp
  • A to G, chromosome 7 at 100,824,225 bp
  • A to T, chromosome 7 at 120,141,834 bp
  • A to G, chromosome 7 at 126,290,011 bp
  • T to C, chromosome 8 at 18,934,458 bp
  • T to A, chromosome 8 at 47,413,152 bp
  • G to A, chromosome 9 at 15,263,766 bp
  • G to T, chromosome 9 at 22,018,599 bp
  • A to G, chromosome 9 at 50,638,054 bp
  • G to A, chromosome 9 at 58,844,036 bp
  • A to T, chromosome 9 at 88,479,685 bp
  • A to G, chromosome 10 at 11,343,676 bp
  • G to T, chromosome 10 at 31,534,732 bp
  • T to G, chromosome 10 at 81,246,079 bp
  • C to A, chromosome 10 at 82,652,737 bp
  • C to T, chromosome 11 at 45,984,792 bp
  • T to C, chromosome 11 at 48,947,976 bp
  • T to C, chromosome 11 at 49,148,815 bp
  • A to T, chromosome 11 at 60,479,231 bp
  • T to C, chromosome 11 at 60,797,576 bp
  • G to T, chromosome 11 at 70,608,950 bp
  • G to A, chromosome 12 at 28,633,757 bp
  • C to T, chromosome 12 at 84,611,759 bp
  • T to C, chromosome 14 at 29,346,923 bp
  • T to C, chromosome 14 at 31,502,445 bp
  • A to G, chromosome 15 at 31,465,259 bp
  • A to G, chromosome 15 at 77,099,251 bp
  • T to C, chromosome 15 at 102,340,336 bp
  • A to T, chromosome 16 at 10,542,689 bp
  • A to G, chromosome 17 at 19,532,010 bp
  • G to A, chromosome 17 at 27,566,069 bp
  • T to A, chromosome 18 at 66,859,821 bp
  • A to G, chromosome 18 at 82,632,970 bp
  • A to G, chromosome 19 at 34,040,429 bp
  • T to C, chromosome X at 150,654,234 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3715 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040708-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.