Strain Name:
C57BL/6J-MtgxR3718Btlr/Mmmh
Stock Number:
040710-MU
Citation ID:
RRID:MMRRC_040710-MU
Other Names:
R3718 (G1), C57BL/6J-MtgxR3718Btlr
Major Collection:

Gene Information

Ntsr1
Name: neurotensin receptor 1
Synonyms: NT-1R, Ntsr1, NTR1, NTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: G630026H09Rik, Srisnf2l, Arip4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81000
Homologene: 56698
Ccna2
Name: cyclin A2
Synonyms: Cyca, Ccna, Ccn-1, Ccn1, CycA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12428
HGNC: HGNC:1578
Homologene: 55562
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, Tmem16f, 2900059G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Aspm, D330028K02Rik, MCPH5, Calmbp1, Sha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: 1200006L06Rik, JPDI, ERdj5, D2Ertd706e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66861
Homologene: 10358
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Ubac1
Name: ubiquitin associated domain containing 1
Synonyms: 1110033G07Rik, Kpc2, Ubadc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98766
Homologene: 9409
Nav1
Name: neuron navigator 1
Synonyms: C230080M11Rik, POMFIL3, 9930003A20Rik, steerin-1, unc53H1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Ttn
Name: titin
Synonyms: 2310036G12Rik, mdm, 1100001C23Rik, shru, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, L56, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, LOC381538, Heatr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Txnip
Name: thioredoxin interacting protein
Synonyms: VDUP1, mVDUP1, Hyplip1, THIF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Trim43a
Name: tripartite motif-containing 43A
Synonyms: Gm6021
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 547109
Homologene: 105432
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230613
Homologene: 136292
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Zc3hav1l
Name: zinc finger CCCH-type, antiviral 1-like
Synonyms: B130055L09Rik, E430016P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209032
Homologene: 15425
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Nup210
Name: nucleoporin 210
Synonyms: gp210, Pom210, gp190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54563
Homologene: 41286
Olfr1277
Name: olfactory receptor 1277
Synonyms: MOR248-11, GA_x6K02T2Q125-72321818-72320907
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258391
Homologene: 105176
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Kv10.1, Eag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Parl
Name: presenilin associated, rhomboid-like
Synonyms: D16Ertd607e, PSARL1, PSENIP2, PRO2207, Psarl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 381038
Homologene: 10239
Olfr943
Name: olfactory receptor 943
Synonyms: GA_x6K02T2PVTD-32881408-32882343, MOR171-44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258323
VEGA: 9
Homologene: 110526
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: MTP1, ferroportin1, Ol5, metal transporting protein 1, Pcm, FPN1, IREG1, Slc11a3, Dusg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53945
Homologene: 40959
Adam3
Name: a disintegrin and metallopeptidase domain 3 (cyritestin)
Synonyms: tMDC, Cyrn1, Taz83, ADAM3, Taz83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Il9
Name: interleukin 9
Synonyms: Il-9, P40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16198
VEGA: 13
HGNC: HGNC:6029
Homologene: 492
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Abra
Name: actin-binding Rho activating protein
Synonyms: C130068O12Rik, STARS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223513
VEGA: 15
Homologene: 34713
Olfr1495
Name: olfactory receptor 1495
Synonyms: GA_x6K02T2RE5P-4101369-4102328, MOR266-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258341
Homologene: 73965
Gng11
Name: guanine nucleotide binding protein (G protein), gamma 11
Synonyms: 0610037B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66066
HGNC: HGNC:4403
Homologene: 3045
Alas2
Name: aminolevulinic acid synthase 2, erythroid
Synonyms: 5-aminolevulinate synthase, erythroid-specific ALAS, Alas-2, ALASE, ALAS, ALAS-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 11656
HGNC: HGNC:397
Homologene: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,495,788 bp
  • G to T, chromosome 1 at 45,910,991 bp
  • A to G, chromosome 1 at 105,649,281 bp
  • A to T, chromosome 1 at 135,450,630 bp
  • T to C, chromosome 1 at 139,480,889 bp
  • G to A, chromosome 1 at 139,490,427 bp
  • A to G, chromosome 1 at 192,238,799 bp
  • C to T, chromosome 2 at 26,014,941 bp
  • T to C, chromosome 2 at 52,277,470 bp
  • G to A, chromosome 2 at 76,745,214 bp
  • A to G, chromosome 2 at 80,324,745 bp
  • A to G, chromosome 2 at 111,270,226 bp
  • T to C, chromosome 2 at 180,542,706 bp
  • A to T, chromosome 3 at 36,566,238 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • T to C, chromosome 4 at 106,704,210 bp
  • A to T, chromosome 4 at 112,746,739 bp
  • A to G, chromosome 4 at 145,075,726 bp
  • G to A, chromosome 6 at 4,008,078 bp
  • G to T, chromosome 6 at 38,295,125 bp
  • A to T, chromosome 6 at 91,020,180 bp
  • A to G, chromosome 8 at 24,695,347 bp
  • A to G, chromosome 9 at 39,185,065 bp
  • T to C, chromosome 9 at 88,844,977 bp
  • A to G, chromosome 9 at 106,693,527 bp
  • C to T, chromosome 13 at 42,158,495 bp
  • G to A, chromosome 13 at 56,479,451 bp
  • T to C, chromosome 15 at 41,866,293 bp
  • A to G, chromosome 15 at 95,913,379 bp
  • A to G, chromosome 16 at 20,282,709 bp
  • T to C, chromosome 18 at 61,990,343 bp
  • A to G, chromosome 19 at 4,923,065 bp
  • A to G, chromosome 19 at 13,769,064 bp
  • T to C, chromosome X at 150,560,730 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3718 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040710-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.