Strain Name:
C57BL/6J-MtgxR3794Btlr/Mmmh
Stock Number:
040756-MU
Citation ID:
RRID:MMRRC_040756-MU
Other Names:
R3794 (G1), C57BL/6J-MtgxR3794Btlr
Major Collection:

Gene Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22594
Homologene: 31368
Fasl
Name: Fas ligand (TNF superfamily, member 6)
Synonyms: CD95L, Fas-L, APT1LG1, Fasl, CD178, Tnfsf6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14103
Homologene: 533
Pigv
Name: phosphatidylinositol glycan anchor biosynthesis, class V
Synonyms: D430024F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230801
Homologene: 5354
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 208440
Homologene: 40996
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, Hbxap, 4832420A03Rik, C030033M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: Rbm16, A630086M08Rik, A930036P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106583
VEGA: 17
Homologene: 8928
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75788
Homologene: 10712
F2rl1
Name: coagulation factor II (thrombin) receptor-like 1
Synonyms: Protease-activated receptor-2, Gpcr11, proteinase-activated receptor-2, PAR-2, Par2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14063
VEGA: 13
HGNC: HGNC:3538
Homologene: 21087
Fam129b
Name: family with sequence similarity 129, member B
Synonyms: 9130404D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227737
Homologene: 11269
Htr1a
Name: 5-hydroxytryptamine (serotonin) receptor 1A
Synonyms: Gpcr18, 5-HT1A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 15550
VEGA: 13
HGNC: HGNC:5286
Homologene: 20148
Mobp
Name: myelin-associated oligodendrocytic basic protein
Synonyms: MOBP155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17433
HGNC: HGNC:7189
Homologene: 32040
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230895
Homologene: 15583
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21894
Homologene: 21267
D430042O09Rik
Name: RIKEN cDNA D430042O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233865
Homologene: 45841
Zfp287
Name: zinc finger protein 287
Synonyms: SKAT-2, B230333C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 170740
Homologene: 23244
Dennd5b
Name: DENN/MADD domain containing 5B
Synonyms: D030011O10Rik, 9330160C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 320560
Homologene: 44911
Ttn
Name: titin
Synonyms: D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, mdm, 1100001C23Rik, shru, connectin, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mass1, Gpr98, VLGR1, Mgr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Zfp352
Name: zinc finger protein 352
Synonyms: 2czf48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 236537
Homologene: 45160
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: CLR16.2, Caterpiller 16.2, D230007K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268857
Homologene: 18720
Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, C430014K11Rik, Mll4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Olfr1217
Name: olfactory receptor 1217
Synonyms: GA_x6K02T2Q125-50504545-50503631, MOR233-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258903
Homologene: 73985
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Pon3
Name: paraoxonase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 269823
HGNC: HGNC:9206
Homologene: 37371
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Intin3, Itih-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Pkdcc
Name: protein kinase domain containing, cytoplasmic
Synonyms: MAd1, ESTM17, Adtk1, Vlk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106522
Homologene: 18932
Ndufaf5
Name: NADH:ubiquinone oxidoreductase complex assembly factor 5
Synonyms: 2310003L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69487
Homologene: 11474
Polr2k
Name: polymerase (RNA) II (DNA directed) polypeptide K
Synonyms: RPB10alpha, RPB7.0, RPABC4, RPB12, Mt1a, ABC10-alpha, MafY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17749
HGNC: HGNC:9198
Homologene: 86049
Naga
Name: N-acetyl galactosaminidase, alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17939
VEGA: 15
HGNC: HGNC:7631
Homologene: 221
Olfr129
Name: olfactory receptor 129
Synonyms: MOR263-9, GA_x6K02T2PSCP-2503741-2502776
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258324
Homologene: 133641
4933403O08Rik
Name: RIKEN cDNA 4933403O08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 71030
Homologene: 136349
Ceacam13
Name: carcinoembryonic antigen-related cell adhesion molecule 13
Synonyms: Ceacam13-C2, 1600025J19Rik, Ceacam13-C1, 1600012K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69785
Homologene: 135962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 161,781,737 bp
  • A to T, chromosome 2 at 32,912,598 bp
  • C to T, chromosome 2 at 76,942,437 bp
  • G to T, chromosome 2 at 89,023,426 bp
  • T to A, chromosome 2 at 140,202,923 bp
  • G to T, chromosome 4 at 43,536,295 bp
  • C to T, chromosome 4 at 90,225,149 bp
  • A to G, chromosome 4 at 133,665,191 bp
  • G to A, chromosome 4 at 145,085,437 bp
  • A to G, chromosome 5 at 144,901,175 bp
  • A to G, chromosome 6 at 5,221,578 bp
  • A to T, chromosome 6 at 149,101,217 bp
  • A to G, chromosome 7 at 18,013,415 bp
  • A to G, chromosome 7 at 24,570,560 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • A to G, chromosome 7 at 125,820,089 bp
  • T to C, chromosome 8 at 82,033,216 bp
  • A to T, chromosome 9 at 120,167,967 bp
  • T to C, chromosome 10 at 24,831,732 bp
  • G to T, chromosome 11 at 62,714,244 bp
  • T to C, chromosome 13 at 9,604,561 bp
  • T to A, chromosome 13 at 81,283,367 bp
  • A to G, chromosome 13 at 95,513,211 bp
  • G to A, chromosome 13 at 105,444,344 bp
  • T to C, chromosome 14 at 30,918,394 bp
  • A to G, chromosome 15 at 36,175,047 bp
  • G to T, chromosome 15 at 82,332,323 bp
  • C to T, chromosome 15 at 98,598,943 bp
  • T to C, chromosome 15 at 98,837,359 bp
  • T to C, chromosome 16 at 3,947,875 bp
  • A to G, chromosome 17 at 3,190,249 bp
  • A to G, chromosome 17 at 38,054,895 bp
  • A to G, chromosome 17 at 83,223,953 bp
  • C to T, chromosome 18 at 63,081,793 bp
  • T to G, chromosome X at 112,240,678 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3794 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040756-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.