Strain Name:
C57BL/6J-MtgxR3831Btlr/Mmmh
Stock Number:
040777-MU
Citation ID:
RRID:MMRRC_040777-MU
Other Names:
R3831 (G1), C57BL/6J-MtgxR3831Btlr
Major Collection:

Strain Information

Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20349
Homologene: 8247
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Phf14
Name: PHD finger protein 14
Synonyms: 4932409F11Rik, 1110001C23Rik, 5730446A07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Bcat-1, BCATc, Eca39
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Zcchc17
Name: zinc finger, CCHC domain containing 17
Synonyms: 2810055E05Rik, HSPC251, Ps1d
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 619605
Homologene: 32319
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Chchd3
Name: coiled-coil-helix-coiled-coil-helix domain containing 3
Synonyms: 0610041L09Rik, 1700039J09Rik, Micos19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66075
Homologene: 9851
S100a10
Name: S100 calcium binding protein A10 (calpactin)
Synonyms: p10, 42C, CLP11, CAL12, Cal1l
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20194
Homologene: 2228
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: Pir121, 6430511D02Rik, 1500004I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76884
Homologene: 7936
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rinp, Rip1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19766
Homologene: 2820
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Rgs5
Name: regulator of G-protein signaling 5
Synonyms: 1110070A02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19737
Homologene: 2682
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 360216
Homologene: 9728
Kremen1
Name: kringle containing transmembrane protein 1
Synonyms: Krm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 84035
Homologene: 12935
Med12
Name: mediator complex subunit 12
Synonyms: Trap230, Mopa, Tnrc11, OPA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 59024
Homologene: 68441
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pipp, Pib5pa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Itih5
Name: inter-alpha-trypsin inhibitor, heavy chain 5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209378
Homologene: 57115
Lzic
Name: leucine zipper and CTNNBIP1 domain containing
Synonyms: 1810030J04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69151
Homologene: 12301
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: 2410022J09Rik, Fbp28, Taf2s, 2900090C16Rik, ca150, p144
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56070
Homologene: 4879
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Pja2
Name: praja ring finger ubiquitin ligase 2
Synonyms: Neurodap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224938
Homologene: 32233
Dpp9
Name: dipeptidylpeptidase 9
Synonyms: DPRP2, 6430584G11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224897
VEGA: 17
Homologene: 16385
Pdgfd
Name: platelet-derived growth factor, D polypeptide
Synonyms: 1110003I09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71785
VEGA: 9
Homologene: 11875
Thsd1
Name: thrombospondin, type I, domain 1
Synonyms: 4833423O18Rik, Tmtsp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56229
Homologene: 10264
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, Cav1.2, Cchl1a1, L-type Cav1.2, D930026N18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Itpkb
Name: inositol 1,4,5-trisphosphate 3-kinase B
Synonyms: E130307H12Rik, 1110033J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320404
HGNC: HGNC:6179
Homologene: 1672
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213945
Homologene: 66345
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: 1110034K09Rik, NaG, Nax, Nav2.3, Nav2, Scn6a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Kcnn3
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms: small conductance calcium-activated potassium channel 3, SK3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140493
HGNC: HGNC:6292
Homologene: 20516
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: B230396K10Rik, 2810012G08Rik, Cytsb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432572
Homologene: 45157
Or56a4
Name: olfactory receptor family 56 subfamily A member 4
Synonyms: Olfr684, MOR40-8P, GA_x6K02T2PBJ9-7786441-7785503
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244187
Homologene: 133596
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 2010203O03Rik, 9430041O17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234214
Homologene: 83295
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC-I, SREC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380713
Homologene: 2741
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Smarca5
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Synonyms: D330027N15Rik, 4933427E24Rik, Snf2h, MommeD4, D030040M08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93762
Homologene: 55764
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237926
Homologene: 41252
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216019
Homologene: 128937
Kics2
Name: KICSTOR subunit 2
Synonyms: BC048403
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270802
Homologene: 17580
Or2t45
Name: olfactory receptor family 2 subfamily T member 45
Synonyms: GA_x6K02T2NKPP-630272-629343, Olfr315, MOR278-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258531
Homologene: 128134
Tekt1
Name: tektin 1
Synonyms: MT14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21689
Homologene: 7973
Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
Synonyms: P450c1, Cyp40, Cyp27b, VddrI, Pddr, 25(OH)D 1alpha-hydroxylase, Vdd1, Vddr, Cyp1, 25-hydroxyvitamin D3 1alpha-hydroxylase, P450VD1alpha, 1alpha(OH)ase, Cp2b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13115
HGNC: HGNC:2606
Homologene: 37139
Or9e1
Name: olfactory receptor family 9 subfamily E member 1
Synonyms: Olfr311, GA_x6K02T2NKPP-565870-564944, MOR222-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258530
Homologene: 77375
Med22
Name: mediator complex subunit 22
Synonyms: Surf5, Surf-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20933
Homologene: 4913
Pgc
Name: progastricsin (pepsinogen C)
Synonyms: 2210410L06Rik, Upg-1, Upg1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 109820
HGNC: HGNC:8890
Homologene: 55669
Hao1
Name: hydroxyacid oxidase 1, liver
Synonyms: Gox1, Hao-1, GOX
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15112
HGNC: HGNC:4809
Homologene: 6578
Cibar2
Name: CBY1 interacting BAR domain containing 2
Synonyms: Fam92b, 1700120B06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 436062
Homologene: 78513
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: b2b2346Clo, ERK5, BMK1, big MAP kinase 1, Erk5-T
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Selp
Name: selectin, platelet
Synonyms: CD62P, Grmp, P-selectin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20344
Homologene: 2260
Samd11
Name: sterile alpha motif domain containing 11
Synonyms: mr-s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231004
VEGA: 4
Homologene: 34983
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Nap1l3
Name: nucleosome assembly protein 1-like 3
Synonyms: MB20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54561
HGNC: HGNC:7639
Homologene: 3334
Sco1
Name: SCO1 cytochrome c oxidase assembly protein
Synonyms: 2610001C07Rik, D11Bwg1310e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52892
Homologene: 3374
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: 9330151E16Rik, neuferricin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192986
Homologene: 14701
Mageh1
Name: MAGE family member H1
Synonyms: APR-1, 2010107K23Rik, APR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75625
Homologene: 8545
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 11,156,364 bp
  • T to A, chromosome 1 at 164,132,280 bp
  • A to G, chromosome 1 at 169,676,901 bp
  • A to T, chromosome 1 at 173,860,378 bp
  • GAAA to GAA, chromosome 1 at 178,916,616 bp
  • T to C, chromosome 1 at 180,333,695 bp
  • A to G, chromosome 2 at 10,251,270 bp
  • A to T, chromosome 2 at 14,981,425 bp
  • A to G, chromosome 2 at 26,910,367 bp
  • A to G, chromosome 2 at 66,697,684 bp
  • A to T, chromosome 2 at 134,523,005 bp
  • T to C, chromosome 3 at 89,667,077 bp
  • T to C, chromosome 3 at 93,564,373 bp
  • C to A, chromosome 4 at 44,345,021 bp
  • T to C, chromosome 4 at 106,362,012 bp
  • A to T, chromosome 4 at 113,885,831 bp
  • T to C, chromosome 4 at 130,338,524 bp
  • G to C, chromosome 4 at 149,488,728 bp
  • A to G, chromosome 4 at 156,250,323 bp
  • T to A, chromosome 5 at 14,226,482 bp
  • A to G, chromosome 6 at 8,097,014 bp
  • A to G, chromosome 6 at 11,933,874 bp
  • G to T, chromosome 6 at 28,531,404 bp
  • T to C, chromosome 6 at 33,008,468 bp
  • T to A, chromosome 6 at 97,412,525 bp
  • A to G, chromosome 6 at 118,604,463 bp
  • T to A, chromosome 6 at 145,010,108 bp
  • A to G, chromosome 7 at 105,157,382 bp
  • C to T, chromosome 7 at 132,982,776 bp
  • T to G, chromosome 8 at 22,243,116 bp
  • A to T, chromosome 8 at 45,795,095 bp
  • A to T, chromosome 8 at 80,728,494 bp
  • T to A, chromosome 8 at 120,174,894 bp
  • T to C, chromosome 9 at 6,359,762 bp
  • A to G, chromosome 9 at 49,035,638 bp
  • T to C, chromosome 9 at 55,973,708 bp
  • T to G, chromosome 9 at 122,852,476 bp
  • T to C, chromosome 10 at 62,400,212 bp
  • T to C, chromosome 10 at 121,745,316 bp
  • G to T, chromosome 10 at 127,051,060 bp
  • T to C, chromosome 11 at 3,500,229 bp
  • G to GGGC, chromosome 11 at 5,201,794 bp
  • A to T, chromosome 11 at 35,688,682 bp
  • T to C, chromosome 11 at 46,261,506 bp
  • T to A, chromosome 11 at 58,778,745 bp
  • T to G, chromosome 11 at 58,841,860 bp
  • A to G, chromosome 11 at 61,489,854 bp
  • T to A, chromosome 11 at 62,117,967 bp
  • T to C, chromosome 11 at 67,053,779 bp
  • T to C, chromosome 11 at 72,354,819 bp
  • G to T, chromosome 11 at 72,795,523 bp
  • T to C, chromosome 11 at 75,515,252 bp
  • A to G, chromosome 11 at 94,543,304 bp
  • A to T, chromosome 11 at 104,287,135 bp
  • T to C, chromosome 13 at 34,026,733 bp
  • C to T, chromosome 17 at 33,137,259 bp
  • C to A, chromosome 17 at 47,729,311 bp
  • A to T, chromosome 17 at 56,199,113 bp
  • T to C, chromosome 17 at 64,309,402 bp
  • G to T, chromosome 18 at 42,568,489 bp
  • T to G, chromosome 19 at 21,847,951 bp
  • C to A, chromosome X at 101,295,892 bp
  • A to G, chromosome X at 122,396,298 bp
  • A to T, chromosome X at 153,037,008 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3831 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040777-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.