Strain Name:
C57BL/6J-MtgxR3858Btlr/Mmmh
Stock Number:
040786-MU
Citation ID:
RRID:MMRRC_040786-MU
Other Names:
R3858 (G1), C57BL/6J-MtgxR3858Btlr
Major Collection:

Gene Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: Grg4, ESTM13, ESTM14, Bce1, 5730411M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Pmp22
Name: peripheral myelin protein 22
Synonyms: Gas-3, TRE002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18858
HGNC: HGNC:9118
Homologene: 7482
Rtn4rl2
Name: reticulon 4 receptor-like 2
Synonyms: Ngr2, Ngrh1, Ngrl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269295
Homologene: 18683
Cd2ap
Name: CD2-associated protein
Synonyms: METS-1, Mets1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12488
VEGA: 17
Homologene: 7663
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Mib1
Name: mindbomb E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, Mib, skeletrophin, mind bomb-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225164
Homologene: 10810
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Zfp512
Name: zinc finger protein 512
Synonyms: 2500002M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269639
Homologene: 13026
Irs4
Name: insulin receptor substrate 4
Synonyms: IRS-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 16370
HGNC: HGNC:6128
Homologene: 137235
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18733
HGNC: HGNC:6607
Homologene: 134028
Ccng1
Name: cyclin G1
Synonyms: cyclin G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12450
HGNC: HGNC:1592
Homologene: 2995
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Synonyms: St15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 53614
Homologene: 9622
Mtmr4
Name: myotubularin related protein 4
Synonyms: ESTM44, FYVE-DSP2, FYVE zinc finger phosphatase, ZFYVE11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Slc4a1
Name: solute carrier family 4 (anion exchanger), member 1
Synonyms: erythrocyte membrane protein band 3, band 3, Empb3, Ae1, CD233, l11Jus51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20533
Homologene: 133556
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: Mdr1, Mdr1b, mdr, Pgy1, Pgy-1, Abcb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18669
Homologene: 69084
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Slc28a2
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Synonyms: CNT2, 2010208B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269346
Homologene: 20891
Pth2r
Name: parathyroid hormone 2 receptor
Synonyms: Pthr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213527
HGNC: HGNC:9609
Homologene: 3701
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625109
Homologene: 129606
Olfr1475
Name: olfactory receptor 1475
Synonyms: GA_x6K02T2RE5P-3812807-3811863, MOR202-36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258298
Homologene: 77370
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22626
Homologene: 65865
H2-Q6
Name: histocompatibility 2, Q region locus 6
Synonyms: Qa6, Qa-6, H-2Q6, 0610037M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 110557
HGNC: HGNC:4931
Homologene: 128352
Tmem29
Name: transmembrane protein 29
Synonyms: 2700081K05Rik, 6330540D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 382245
Homologene: 136288
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Olfr103
Name: olfactory receptor 103
Synonyms: MOR250-3, GA_x6K02T2PSCP-1798423-1797482, MOR250-8_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258830
Homologene: 115555
Hs3st1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms: 3-OST, D5Wsu110e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15476
HGNC: HGNC:5194
Homologene: 3751
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Kcnmb2
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 2
Synonyms: 3110031N04Rik, 2700049B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72413
HGNC: HGNC:6286
Homologene: 4257
Tor3a
Name: torsin family 3, member A
Synonyms: Adir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 30935
Homologene: 23359
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 65,322,047 bp
  • A to G, chromosome 1 at 67,168,278 bp
  • A to G, chromosome 1 at 75,129,396 bp
  • T to A, chromosome 1 at 156,669,554 bp
  • A to G, chromosome 2 at 84,880,386 bp
  • A to G, chromosome 2 at 91,012,741 bp
  • T to C, chromosome 2 at 122,458,157 bp
  • T to C, chromosome 3 at 32,198,301 bp
  • A to G, chromosome 3 at 72,928,652 bp
  • A to G, chromosome 4 at 43,930,261 bp
  • T to A, chromosome 5 at 8,813,581 bp
  • G to T, chromosome 5 at 31,472,840 bp
  • G to A, chromosome 5 at 39,614,913 bp
  • C to T, chromosome 6 at 12,555,226 bp
  • T to C, chromosome 7 at 3,717,663 bp
  • G to A, chromosome 9 at 13,252,079 bp
  • A to G, chromosome 10 at 130,455,725 bp
  • A to G, chromosome 11 at 40,753,833 bp
  • A to G, chromosome 11 at 59,080,969 bp
  • T to C, chromosome 11 at 63,134,475 bp
  • G to A, chromosome 11 at 87,597,262 bp
  • A to T, chromosome 11 at 102,357,121 bp
  • A to G, chromosome 14 at 28,475,642 bp
  • C to T, chromosome 17 at 35,425,566 bp
  • A to T, chromosome 17 at 37,337,226 bp
  • G to A, chromosome 17 at 42,816,572 bp
  • A to G, chromosome 17 at 53,462,780 bp
  • T to A, chromosome 18 at 10,798,409 bp
  • T to C, chromosome 18 at 57,275,835 bp
  • A to G, chromosome 19 at 9,010,859 bp
  • T to A, chromosome 19 at 13,480,130 bp
  • G to A, chromosome 19 at 14,468,213 bp
  • A to G, chromosome 19 at 21,852,234 bp
  • T to C, chromosome X at 141,724,063 bp
  • T to C, chromosome X at 150,420,361 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3858 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040786-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.