Strain Name:
C57BL/6J-MtgxR3910Btlr/Mmmh
Stock Number:
040815-MU
Citation ID:
RRID:MMRRC_040815-MU
Other Names:
R3910 (G1), C57BL/6J-MtgxR3910Btlr
Major Collection:

Strain Information

Mycn
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
Synonyms: bHLHe37, N-myc, Nmyc, Nmyc1, Nmyc-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18109
HGNC: HGNC:7559
Homologene: 3922
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: Vsp35l, 9030624J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Robo3
Name: roundabout guidance receptor 3
Synonyms: Robo3a, Rbig1, Rig1, Rig-1, Robo3b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19649
Homologene: 32119
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: mSmile, 9130014E20Rik, B130008E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237500
Homologene: 27616
Gab2
Name: growth factor receptor bound protein 2-associated protein 2
Synonyms: p97, D130058I17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14389
Homologene: 69067
Fcrl2
Name: Fc receptor like 2
Synonyms: Fcrls, 2810439C17Rik, IFGP2, Msr2, Fcrh2, moFcRH2sc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Kirrel1
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Kirrel, Kirrel1, 6720469N11Rik, Neph1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170643
Homologene: 10089
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Pax3/7bp, 1810007M14Rik, Gcfc1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67367
Homologene: 9604
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: OPG, Opg, osteoclastogenesis inhibitory factor, OCIF, TR1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: Thm1, 2410066K11Rik, line 158, aln
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Trim30, Rpt-1, Rpt1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20128
Homologene: 114426
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Ugt1a8
Name: UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms: OTTMUSG00000020811, A116
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 613123
Prr5
Name: proline rich 5 (renal)
Synonyms: Protor-1, C030017C09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109270
Homologene: 17132
Krt90
Name: keratin 90
Synonyms: 4732456N10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239673
Homologene: 72272
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Iqca1l
Name: IQ motif containing with AAA domain 1 like
Synonyms: 4931409K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231045
Homologene: 18602
Or9a2
Name: olfactory receptor family 9 subfamily A member 2
Synonyms: GA_x6K02T2P3E9-5780974-5781915, MOR120-1, Olfr459
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258569
Homologene: 83448
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 104349
Phc2
Name: polyhomeotic 2
Synonyms: Edr2, D130050K19Rik, Mph2, D4Ertd810e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Or2ag18
Name: olfactory receptor family 2 subfamily AG member 18
Synonyms: MOR283-4, GA_x6K02T2PBJ9-9184187-9183237, Olfr700
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258593
Homologene: 64895
Vmn1r75
Name: vomeronasal 1 receptor 75
Synonyms: V1rg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171241
Homologene: 44234
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240084
Homologene: 10396
CT485612.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Cimip3
Name: ciliary microtubule inner protein 3
Synonyms: 1700001C19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75462
Homologene: 129540
Fbxo3
Name: F-box protein 3
Synonyms: Fba, 1200002G09Rik, 1700026K02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57443
Homologene: 8133
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,088,048 bp
  • A to G, chromosome 2 at 62,556,104 bp
  • A to G, chromosome 2 at 66,207,548 bp
  • T to C, chromosome 2 at 104,055,032 bp
  • A to T, chromosome 3 at 79,479,505 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to T, chromosome 3 at 87,259,351 bp
  • A to T, chromosome 4 at 58,145,156 bp
  • T to C, chromosome 4 at 128,743,558 bp
  • A to T, chromosome 5 at 24,545,442 bp
  • T to C, chromosome 5 at 41,817,098 bp
  • A to G, chromosome 6 at 12,331,549 bp
  • A to T, chromosome 6 at 29,459,427 bp
  • A to G, chromosome 6 at 41,772,149 bp
  • A to T, chromosome 7 at 11,880,830 bp
  • A to G, chromosome 7 at 97,299,073 bp
  • A to G, chromosome 7 at 104,411,141 bp
  • A to T, chromosome 7 at 106,805,865 bp
  • A to G, chromosome 7 at 118,746,390 bp
  • T to A, chromosome 8 at 68,813,620 bp
  • A to T, chromosome 9 at 37,419,295 bp
  • A to G, chromosome 10 at 39,820,556 bp
  • A to C, chromosome 10 at 100,449,026 bp
  • A to G, chromosome 10 at 115,587,463 bp
  • T to A, chromosome 12 at 12,937,280 bp
  • C to T, chromosome 12 at 88,284,594 bp
  • G to A, chromosome 15 at 54,256,182 bp
  • T to A, chromosome 15 at 84,703,144 bp
  • G to A, chromosome 15 at 101,562,783 bp
  • T to A, chromosome 16 at 91,042,681 bp
  • T to C, chromosome 17 at 35,525,336 bp
  • AC to A, chromosome 17 at 47,433,423 bp
  • G to A, chromosome 17 at 55,866,520 bp
  • T to C, chromosome 18 at 20,266,196 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040815-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.