Strain Name:
C57BL/6J-MtgxR3910Btlr/Mmmh
Stock Number:
040815-MU
Citation ID:
RRID:MMRRC_040815-MU
Other Names:
R3910 (G1), C57BL/6J-MtgxR3910Btlr
Major Collection:

Gene Information

Mycn
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
Synonyms: Nmyc, N-myc, Nmyc-1, Nmyc1, bHLHe37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18109
HGNC: HGNC:7559
Homologene: 3922
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71517
Homologene: 10659
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig-1, Rbig1, Robo3b, Robo3a, Rig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19649
Homologene: 32119
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: 9130014E20Rik, B130008E12Rik, mSmile
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237500
Homologene: 27616
Gab2
Name: growth factor receptor bound protein 2-associated protein 2
Synonyms: p97, D130058I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14389
Homologene: 69067
Fcrls
Name: Fc receptor-like S, scavenger receptor
Synonyms: 2810439C17Rik, IFGP2, Fcrh2, moFcRH2sc, Msr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80891
Homologene: 57117
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: 1810007M14Rik, Pax3/7bp, Gcfc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67367
Homologene: 9604
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70885
Homologene: 10029
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, line 158, Thm1, aln
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73668
Homologene: 57006
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20128
Homologene: 114426
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Ugt1a8
Name: UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms: A116, OTTMUSG00000020811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Prr5
Name: proline rich 5 (renal)
Synonyms: C030017C09Rik, Protor-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109270
Homologene: 17132
Krt90
Name: keratin 90
Synonyms: 4732456N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239673
Homologene: 72272
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329679
Homologene: 46417
Iqca1l
Name: IQ motif containing with AAA domain 1 like
Synonyms: 4931409K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231045
Homologene: 18602
Olfr459
Name: olfactory receptor 459
Synonyms: GA_x6K02T2P3E9-5780974-5781915, MOR120-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258569
Homologene: 83448
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 104349
Phc2
Name: polyhomeotic 2
Synonyms: Mph2, D4Ertd810e, Edr2, D130050K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Olfr700
Name: olfactory receptor 700
Synonyms: GA_x6K02T2PBJ9-9184187-9183237, MOR283-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258593
Homologene: 64895
Vmn1r75
Name: vomeronasal 1 receptor 75
Synonyms: V1rg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171241
Homologene: 44234
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240084
Homologene: 10396
CT485612.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
1700001C19Rik
Name: RIKEN cDNA 1700001C19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75462
Homologene: 129540
Fbxo3
Name: F-box protein 3
Synonyms: Fba, 1200002G09Rik, 1700026K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57443
Homologene: 8133
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,088,048 bp
  • A to G, chromosome 2 at 62,556,104 bp
  • A to G, chromosome 2 at 66,207,548 bp
  • T to C, chromosome 2 at 104,055,032 bp
  • A to T, chromosome 3 at 79,479,505 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to T, chromosome 3 at 87,259,351 bp
  • A to T, chromosome 4 at 58,145,156 bp
  • T to C, chromosome 4 at 128,743,558 bp
  • A to T, chromosome 5 at 24,545,442 bp
  • T to C, chromosome 5 at 41,817,098 bp
  • A to G, chromosome 6 at 12,331,549 bp
  • A to T, chromosome 6 at 29,459,427 bp
  • A to G, chromosome 6 at 41,772,149 bp
  • A to T, chromosome 7 at 11,880,830 bp
  • A to G, chromosome 7 at 97,299,073 bp
  • A to G, chromosome 7 at 104,411,141 bp
  • A to T, chromosome 7 at 106,805,865 bp
  • A to G, chromosome 7 at 118,746,390 bp
  • T to A, chromosome 8 at 68,813,620 bp
  • A to T, chromosome 9 at 37,419,295 bp
  • A to G, chromosome 10 at 39,820,556 bp
  • A to C, chromosome 10 at 100,449,026 bp
  • A to G, chromosome 10 at 115,587,463 bp
  • T to A, chromosome 12 at 12,937,280 bp
  • C to T, chromosome 12 at 88,284,594 bp
  • G to A, chromosome 15 at 54,256,182 bp
  • T to A, chromosome 15 at 84,703,144 bp
  • G to A, chromosome 15 at 101,562,783 bp
  • T to A, chromosome 16 at 91,042,681 bp
  • T to C, chromosome 17 at 35,525,336 bp
  • AC to A, chromosome 17 at 47,433,423 bp
  • G to A, chromosome 17 at 55,866,520 bp
  • T to C, chromosome 18 at 20,266,196 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040815-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.