Strain Name:
C57BL/6J-MtgxR3922Btlr/Mmmh
Stock Number:
040819-MU
Citation ID:
RRID:MMRRC_040819-MU
Other Names:
R3922 (G1), C57BL/6J-MtgxR3922Btlr
Major Collection:

Gene Information

Cep70
Name: centrosomal protein 70
Synonyms: C030018L16Rik, 6720484E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68121
Homologene: 11387
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: P4h-tm, 4933406E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74443
Homologene: 41765
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235323
VEGA: 9
Homologene: 10840
Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 72515
VEGA: 17
Homologene: 38810
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: Zfp289, 2310032E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77038
Homologene: 8735
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243272
Homologene: 10055
Arid1b
Name: AT rich interactive domain 1B (SWI-like)
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 239985
Homologene: 32344
Sft2d1
Name: SFT2 domain containing 1
Synonyms: 5630401J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106489
Homologene: 34525
Egfr
Name: epidermal growth factor receptor
Synonyms: Errb1, Wa5, 9030024J15Rik, Erbb, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Gpr89
Name: G protein-coupled receptor 89
Synonyms: 4933412D19Rik, SH120
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67549
Homologene: 9475
Cntrl
Name: centriolin
Synonyms: b2b1468Clo, 6720467O09Rik, IB3/5, Cep110, Cep1, Ma2a8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69582
Homologene: 19575
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, ZFYVE2, A430109M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231637
Homologene: 41299
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: RhoGEF, p190RhoGEF, Rgnef, 9230110L08Rik, D13Bwg1089e, RIP2, Rho specific exchange factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110596
VEGA: 13
Homologene: 8078
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80892
Homologene: 23477
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 674895
Homologene: 130947
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20274
Homologene: 2237
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 629499
Homologene: 51864
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 1110004P15Rik, 2310047C17Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Olfr615
Name: olfactory receptor 615
Synonyms: MOR19-2, GA_x6K02T2PBJ9-6284902-6285843
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259084
HGNC: null
Homologene: 17494
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243914
Homologene: 16408
Trp63
Name: transformation related protein 63
Synonyms: p63, KET protein, TAp63, deltaNp63, p51/p63, Trp53rp1, p73L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22061
Homologene: 31189
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPS, D1Ucla3, CPSase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Zfp108
Name: zinc finger protein 108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54678
HGNC: null
Homologene: 117959
Slc35g2
Name: solute carrier family 35, member G2
Synonyms: LOC245020, Tmem22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245020
Homologene: 11893
Cdkl1
Name: cyclin-dependent kinase-like 1 (CDC2-related kinase)
Synonyms: 4933411O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Ddx59
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
Synonyms: 1210002B07Rik, 4833411G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67997
Homologene: 12222
Olfr1501
Name: olfactory receptor 1501
Synonyms: MOR212-3, GA_x6K02T2RE5P-4171358-4170411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258626
HGNC: null
Homologene: 64899
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: FLIPT2, OCT6, CT2, 4921504E14Rik, OKB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70840
Homologene: 41957
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 80721
Homologene: 23530
Olfr769
Name: olfactory receptor 769
Synonyms: GA_x6K02T2PULF-10797876-10796938, MOR114-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 257667
Homologene: 121502
Dtd2
Name: D-tyrosyl-tRNA deacylase 2
Synonyms: 4930578F06Rik, 6530401N04Rik, B830049N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 328092
Homologene: 12634
Pramel5
Name: preferentially expressed antigen in melanoma like 5
Synonyms: OTTMUSG00000010540
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 384077
HGNC: null
Homologene: 133722
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70909
Homologene: 87049
Slc27a3
Name: solute carrier family 27 (fatty acid transporter), member 3
Synonyms: FATP3, Acsvl3, fatty acid transport protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26568
Homologene: 11529
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69324
HGNC: null
Homologene: 78000
Esd
Name: esterase D/formylglutathione hydrolase
Synonyms: Esd, Es-10, Es10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13885
HGNC: HGNC:3465
Homologene: 55623
Zfp353-ps
Name: zinc finger protein 353, pseudogene
Synonyms: Zfp353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234203
HGNC: null
Homologene: null
H2-M10.1
Name: histocompatibility 2, M region locus 10.1
Synonyms: 9.5H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14985
HGNC: null
Homologene: 117973
Sepx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 67,172,879 bp
  • A to T, chromosome 1 at 83,022,957 bp
  • T to A, chromosome 1 at 136,416,744 bp
  • T to A, chromosome 2 at 19,480,560 bp
  • A to G, chromosome 2 at 35,129,739 bp
  • C to A, chromosome 2 at 40,677,581 bp
  • T to A, chromosome 2 at 66,526,873 bp
  • T to C, chromosome 2 at 69,506,376 bp
  • C to T, chromosome 2 at 91,274,805 bp
  • T to C, chromosome 2 at 157,222,811 bp
  • A to G, chromosome 3 at 5,400,647 bp
  • G to T, chromosome 3 at 90,387,085 bp
  • A to T, chromosome 3 at 96,890,899 bp
  • T to C, chromosome 4 at 141,629,532 bp
  • A to G, chromosome 4 at 144,273,052 bp
  • T to G, chromosome 5 at 113,942,708 bp
  • T to C, chromosome 5 at 124,381,930 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • G to A, chromosome 7 at 24,261,348 bp
  • A to T, chromosome 7 at 31,067,448 bp
  • T to C, chromosome 7 at 103,560,705 bp
  • A to T, chromosome 8 at 42,083,012 bp
  • T to C, chromosome 9 at 49,030,923 bp
  • T to A, chromosome 9 at 99,275,579 bp
  • A to T, chromosome 9 at 100,552,727 bp
  • T to C, chromosome 9 at 108,582,895 bp
  • T to A, chromosome 10 at 40,585,398 bp
  • T to A, chromosome 10 at 96,036,633 bp
  • C to A, chromosome 10 at 129,111,613 bp
  • T to A, chromosome 11 at 16,881,495 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • G to C, chromosome 12 at 52,004,951 bp
  • G to T, chromosome 12 at 69,756,599 bp
  • A to G, chromosome 13 at 97,993,944 bp
  • T to C, chromosome 14 at 14,861,585 bp
  • A to T, chromosome 14 at 74,743,227 bp
  • A to G, chromosome 16 at 25,889,009 bp
  • T to C, chromosome 17 at 5,343,041 bp
  • G to T, chromosome 17 at 8,318,882 bp
  • T to C, chromosome 17 at 24,740,083 bp
  • T to A, chromosome 17 at 36,325,685 bp
  • A to G, chromosome 17 at 71,638,301 bp
  • G to A, chromosome 19 at 9,006,328 bp
  • T to C, chromosome 19 at 13,838,766 bp
  • A to G, chromosome 19 at 43,440,445 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3922 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040819-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.