Strain Name:
C57BL/6J-MtgxR3952Btlr/Mmmh
Stock Number:
040829-MU
Citation ID:
RRID:MMRRC_040829-MU
Other Names:
R3952 (G1), C57BL/6J-MtgxR3952Btlr
Major Collection:

Gene Information

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16396
Homologene: 88442
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50492
Homologene: 55726
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77011
Homologene: 67120
Kpna2
Name: karyopherin (importin) alpha 2
Synonyms: pendulin, m-importin, m-importin-alpha-P1, Rch1, 2410044B12Rik, Importin alpha, importin alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16647
HGNC: HGNC:6395
Homologene: 1708
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Nil2, [delta]EF1, MEB1, Tcf8, Zfx1a, Tcf18, AREB6, ZEB, Zfhep, 3110032K11Rik, Zfhx1a, Tw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21417
Homologene: 31779
Kpna1
Name: karyopherin (importin) alpha 1
Synonyms: mSRP1, m-importin-alpha-S1, Rch2, NPI1, importin alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16646
HGNC: HGNC:6394
Homologene: 55642
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, Vam6, mVam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269338
Homologene: 41025
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, B230120H23Rik, Zak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65964
Homologene: 32331
Arntl
Name: aryl hydrocarbon receptor nuclear translocator-like
Synonyms: Arnt3, MOP3, Bmal1, bHLHe5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11865
HGNC: HGNC:701
Homologene: 910
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231214
Homologene: 18159
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237339
Homologene: 18226
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Rcor1
Name: REST corepressor 1
Synonyms: 6720480E22Rik, D12Wsu95e, Rocr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217864
Homologene: 32246
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381280
Homologene: 10184
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: mTIA-1, 2310050N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21841
Homologene: 20692
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: D6Ertd71e, D6Wsu16e, Copg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Dera
Name: deoxyribose-phosphate aldolase (putative)
Synonyms: 2010002D22Rik, 2500002K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232449
Homologene: 14562
Brd8
Name: bromodomain containing 8
Synonyms: p120, SMAP, 2610007E11Rik, 4432404P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78656
Homologene: 41790
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Rtn4ip1
Name: reticulon 4 interacting protein 1
Synonyms: NIMP, D10Ertd690e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170728
Homologene: 13105
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80797
Homologene: 77224
Zxdc
Name: ZXD family zinc finger C
Synonyms: B930086F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 80292
Homologene: 82340
Fads2b
Name: fatty acid desaturase 2B
Synonyms: 4833423E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228151
Homologene: 105643
1700017N19Rik
Name: RIKEN cDNA 1700017N19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66605
Homologene: 45135
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-a, Slp2, Slp2-d, Slp2-c, Slp2-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83671
Homologene: 131343
Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Synonyms: Gnt1, Udpgt-1a, UGT1A01, UgtBr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394436
Homologene: 128034
Pramel28
Name: PRAME like 28
Synonyms: Gm13101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626922
Pacs2
Name: phosphofurin acidic cluster sorting protein 2
Synonyms: 6720425G15Rik, Pacs1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217893
VEGA: 12
Homologene: 15016
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23805
Homologene: 4299
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75721
Homologene: 138468
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Olfr816
Name: olfactory receptor 816
Synonyms: GA_x6K02T2PULF-11590830-11589892, MOR113-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258667
Homologene: 133584
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Fastkd1
Name: FAST kinase domains 1
Synonyms: 5330408N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320720
Homologene: 36420
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, 1200015G06Rik, Ndst-1, b2b2230Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Arl2
Name: ADP-ribosylation factor-like 2
Synonyms: arf-like protein 2, 2610009M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56327
HGNC: HGNC:693
Homologene: 1260
Prpmp5
Name: proline-rich protein MP5
Synonyms: MP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381832
Olfr519
Name: olfactory receptor 519
Synonyms: GA_x6K02T2PBJ9-11224559-11223615, MOR268-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 277935
Homologene: 17186
Tmod1
Name: tropomodulin 1
Synonyms: E-Tmod, erythrocyte tropomodulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21916
Homologene: 20701
Olfr1128
Name: olfactory receptor 1128
Synonyms: GA_x6K02T2Q125-49048592-49047657, MOR176-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258346
Vmn1r118
Name: vomeronasal 1 receptor 118
Synonyms: Gm8542
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667259
Homologene: 104166
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,450,414 bp
  • A to T, chromosome 1 at 77,399,716 bp
  • C to A, chromosome 1 at 88,216,140 bp
  • G to C, chromosome 1 at 88,277,215 bp
  • A to T, chromosome 2 at 31,784,537 bp
  • T to C, chromosome 2 at 68,664,403 bp
  • A to G, chromosome 2 at 69,702,354 bp
  • T to G, chromosome 2 at 72,438,300 bp
  • T to C, chromosome 2 at 76,752,795 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to C, chromosome 2 at 85,500,204 bp
  • T to C, chromosome 2 at 87,545,065 bp
  • C to T, chromosome 2 at 120,350,175 bp
  • T to C, chromosome 2 at 155,168,837 bp
  • A to G, chromosome 3 at 122,781,644 bp
  • A to G, chromosome 3 at 144,803,061 bp
  • A to G, chromosome 4 at 46,078,315 bp
  • C to T, chromosome 4 at 143,965,786 bp
  • A to G, chromosome 5 at 43,699,928 bp
  • C to A, chromosome 6 at 42,364,285 bp
  • G to A, chromosome 6 at 72,426,558 bp
  • T to C, chromosome 6 at 86,416,337 bp
  • G to A, chromosome 6 at 87,905,216 bp
  • A to G, chromosome 6 at 90,370,467 bp
  • T to C, chromosome 6 at 125,186,784 bp
  • G to A, chromosome 6 at 132,312,694 bp
  • A to G, chromosome 6 at 137,837,120 bp
  • G to T, chromosome 7 at 20,912,008 bp
  • T to C, chromosome 7 at 79,682,069 bp
  • T to A, chromosome 7 at 90,381,492 bp
  • C to A, chromosome 7 at 108,893,982 bp
  • T to C, chromosome 7 at 113,291,447 bp
  • A to G, chromosome 10 at 26,339,312 bp
  • T to A, chromosome 10 at 43,909,897 bp
  • T to C, chromosome 10 at 60,657,326 bp
  • C to T, chromosome 10 at 80,314,484 bp
  • C to T, chromosome 10 at 81,080,629 bp
  • T to C, chromosome 10 at 100,615,296 bp
  • A to G, chromosome 10 at 129,911,636 bp
  • T to C, chromosome 11 at 106,991,845 bp
  • A to G, chromosome 12 at 111,039,735 bp
  • T to C, chromosome 12 at 113,061,113 bp
  • A to G, chromosome 13 at 93,089,199 bp
  • G to T, chromosome 15 at 79,313,096 bp
  • A to T, chromosome 16 at 36,002,882 bp
  • C to T, chromosome 16 at 56,604,038 bp
  • G to A, chromosome 18 at 5,772,716 bp
  • C to G, chromosome 18 at 34,614,444 bp
  • T to C, chromosome 18 at 60,697,139 bp
  • C to T, chromosome 19 at 4,617,967 bp
  • G to T, chromosome 19 at 6,134,677 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3952 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040829-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.