Strain Name:
C57BL/6J-MtgxR4156Btlr/Mmmh
Stock Number:
040862-MU
Citation ID:
RRID:MMRRC_040862-MU
Other Names:
R4156 (G1), C57BL/6J-MtgxR4156Btlr
Major Collection:

Gene Information

Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15950
Homologene: 115929
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56531
Homologene: 87707
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68145
Homologene: 10369
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: nucling, 2700059D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68925
Homologene: 32269
Papola
Name: poly (A) polymerase alpha
Synonyms: Plap, PapIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18789
Homologene: 23389
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Apc1, 2610021O03Rik, Mcpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17222
Homologene: 7414
Arl6ip1
Name: ADP-ribosylation factor-like 6 interacting protein 1
Synonyms: AIP-6, ARMER
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54208
HGNC: HGNC:697
Homologene: 41008
Ndufs4
Name: NADH:ubiquinone oxidoreductase core subunit S4
Synonyms: C1-18k, 6720411N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17993
VEGA: 13
HGNC: HGNC:7711
Homologene: 1866
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 93736
Homologene: 8683
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 52708
VEGA: 12
Homologene: 10918
Ddx20
Name: DEAD box helicase 20
Synonyms: GEMIN3, dp103, DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53975
HGNC: HGNC:2743
Homologene: 5214
Trim33
Name: tripartite motif-containing 33
Synonyms: Tif1g, 8030451N04Rik, ectodermin, Ecto
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94093
Homologene: 9296
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12807
Homologene: 13019
Naxe
Name: NAD(P)HX epimerase
Synonyms: ESTM37, APOA1BP, AI-BP, Apoa1bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 246703
Homologene: 70948
Gamt
Name: guanidinoacetate methyltransferase
Synonyms: Spintz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14431
HGNC: HGNC:4136
Homologene: 32089
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Mtr1, Ltrpc5, 9430099A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56843
Homologene: 22818
Or5h18
Name: olfactory receptor family 5 subfamily H member 18
Synonyms: GA_x54KRFPKG5P-55257214-55256285, MOR183-9, Olfr186
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258318
Homologene: 133671
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, CTIP2, B630002E05Rik, Rit1, 9130430L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58208
Homologene: 10974
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240069
Homologene: 18615
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Acot12
Name: acyl-CoA thioesterase 12
Synonyms: 1300004O04Rik, 4930449F15Rik, Cach
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74156
Homologene: 12540
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030018G17Rik, 1110018I21Rik, Tns, E030037J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21961
Homologene: 11219
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 435864
Homologene: 129606
Or8h8
Name: olfactory receptor family 8 subfamily H member 8
Synonyms: GA_x6K02T2Q125-48410458-48409511, MOR206-1, Olfr1098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258842
Homologene: 37005
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1R1, V1rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81017
Homologene: 41799
Gm1141
Name: predicted gene 1141
Synonyms: LOC382221, Pasd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 382221
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381352
Homologene: 17102
Or8j3c
Name: olfactory receptor family 8 subfamily J member 3C
Synonyms: GA_x6K02T2Q125-47892992-47892045, MOR185-1, Olfr1062
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259082
Homologene: 83135
Ncan
Name: neurocan
Synonyms: Tgfbit, Cspg3, Cspg3-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
2410004B18Rik
Name: RIKEN cDNA 2410004B18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66421
Homologene: 11968
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Ecd
Name: ecdysoneless cell cycle regulator
Synonyms: 5730461K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70601
VEGA: 14
Homologene: 5256
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102642386
Lrrc23
Name: leucine rich repeat containing 23
Synonyms: 4921537K05Rik, Lrpb7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16977
Homologene: 5082
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434117
Homologene: 113703
Ccpg1
Name: cell cycle progression 1
Synonyms: 1700030B06Rik, 1810073J13Rik, D9Ertd392e, 9430028F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72278
Homologene: 3487
Leng9
Name: leukocyte receptor cluster (LRC) member 9
Synonyms: 9530024C23Rik, F630035L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243813
Homologene: 18466
Ffar2
Name: free fatty acid receptor 2
Synonyms: Gpr43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233079
HGNC: HGNC:4501
Homologene: 133911
Srgn
Name: serglycin
Synonyms: Sgc, Prg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19073
HGNC: HGNC:9361
Homologene: 137238
Rpl31-ps17
Name: ribosomal protein L31, pseudogene 17
Synonyms: Gm16382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 673582
Tmem54
Name: transmembrane protein 54
Synonyms: 1810017F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66260
Homologene: 11937
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d1a, Fam75d3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 73,914,631 bp
  • T to A, chromosome 1 at 173,936,540 bp
  • A to G, chromosome 2 at 25,573,697 bp
  • C to A, chromosome 2 at 86,423,200 bp
  • T to C, chromosome 2 at 86,922,878 bp
  • T to C, chromosome 2 at 112,653,675 bp
  • C to T, chromosome 2 at 119,774,179 bp
  • A to G, chromosome 2 at 128,627,229 bp
  • A to G, chromosome 3 at 20,029,229 bp
  • T to C, chromosome 3 at 88,056,704 bp
  • G to T, chromosome 3 at 103,310,314 bp
  • G to T, chromosome 3 at 105,678,933 bp
  • T to A, chromosome 3 at 145,938,263 bp
  • G to A, chromosome 4 at 129,110,711 bp
  • A to G, chromosome 4 at 144,193,953 bp
  • T to C, chromosome 5 at 108,847,877 bp
  • T to A, chromosome 6 at 124,770,841 bp
  • T to C, chromosome 7 at 4,149,434 bp
  • T to C, chromosome 7 at 5,803,532 bp
  • T to C, chromosome 7 at 10,040,382 bp
  • T to A, chromosome 7 at 30,819,668 bp
  • T to C, chromosome 7 at 41,546,086 bp
  • AAAATAAATAAATAAATAAATAAATA to AAAATAAATAAATAAATAAATAAATAAATA, chromosome 7 at 118,121,899 bp
  • G to T, chromosome 7 at 143,089,055 bp
  • C to A, chromosome 8 at 70,110,077 bp
  • A to G, chromosome 9 at 60,871,753 bp
  • C to A, chromosome 9 at 73,012,167 bp
  • A to G, chromosome 10 at 62,497,834 bp
  • T to A, chromosome 10 at 80,260,724 bp
  • C to T, chromosome 11 at 17,940,281 bp
  • T to A, chromosome 11 at 53,410,899 bp
  • C to T, chromosome 12 at 54,701,612 bp
  • G to A, chromosome 12 at 84,327,432 bp
  • T to C, chromosome 12 at 85,057,403 bp
  • G to A, chromosome 12 at 105,800,751 bp
  • A to T, chromosome 12 at 107,917,425 bp
  • G to A, chromosome 12 at 111,294,139 bp
  • T to A, chromosome 13 at 59,705,047 bp
  • C to T, chromosome 13 at 91,784,763 bp
  • A to T, chromosome 13 at 114,307,854 bp
  • A to G, chromosome 14 at 20,324,564 bp
  • A to G, chromosome 15 at 76,172,253 bp
  • G to A, chromosome 15 at 76,402,126 bp
  • A to T, chromosome 16 at 59,027,568 bp
  • T to A, chromosome 17 at 33,138,427 bp
  • A to G, chromosome 19 at 40,551,281 bp
  • T to C, chromosome X at 71,939,555 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4156 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040862-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.