Strain Name:
C57BL/6J-MtgxR4178Btlr/Mmmh
Stock Number:
040864-MU
Citation ID:
RRID:MMRRC_040864-MU
Other Names:
R4178 (G1), C57BL/6J-MtgxR4178Btlr
Major Collection:

Strain Information

Eno1
Name: enolase 1, alpha non-neuron
Synonyms: 2-phospho-D-glycerate hydrolase, alpha-enolase, Eno-1, MBP-1, c-Myc promoter binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Lin9
Name: lin-9 DREAM MuvB core complex component
Synonyms: 2700022J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72568
Homologene: 35252
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Ehd4
Name: EH-domain containing 4
Synonyms: 2210022F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98878
HGNC: HGNC:3245
Homologene: 26430
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
C6
Name: complement component 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Usp6nl
Name: USP6 N-terminal like
Synonyms: TRE2NL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98910
Homologene: 6879
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, D6Abb2e, wms, jog, Tmy, Gena300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Fance
Name: Fanconi anemia, complementation group E
Synonyms: 2810451D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72775
HGNC: HGNC:3586
Homologene: 11066
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, FOG2, B330005D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, 1110030N06Rik, A530078N03Rik, Map3k7ip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68652
Homologene: 9019
Tubgcp6
Name: tubulin, gamma complex associated protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328580
Homologene: 32477
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Zfp775
Name: zinc finger protein 775
Synonyms: C130032F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243372
Homologene: 37089
Obox7
Name: oocyte specific homeobox 7
Synonyms: Gm4745
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 194588
Homologene: 44937
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Or5p1
Name: olfactory receptor family 5 subfamily P member 1
Synonyms: GA_x6K02T2PBJ9-10646917-10647849, MOR204-11, Olfr491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258731
Homologene: 128150
Or5p68
Name: olfactory receptor family 5 subfamily P member 68
Synonyms: GA_x6K02T2PBJ9-10676998-10676054, MOR204-35, Olfr493
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258307
Homologene: 17188
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1291.1Clo, b2b1163.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329795
Homologene: 71886
Rita1
Name: RBPJ interacting and tubulin associated 1
Synonyms: 1110008J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100764
Homologene: 12585
Kcnab2
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms: F5, I2rf5, I2rf5, Kcnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16498
HGNC: HGNC:6229
Homologene: 56492
Gm10322
Name: predicted gene 10322
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100039225
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Gpc2
Name: glypican 2 (cerebroglycan)
Synonyms: 2410016G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71951
HGNC: HGNC:4450
Homologene: 17657
Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Synonyms: C130020P05Rik, BLOC-3, 2010205O06Rik, Hermansky-Pudlak syndrome 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 192232
Homologene: 11123
Fkbp14
Name: FK506 binding protein 14
Synonyms: FKBP22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 231997
Homologene: 23059
Or8g18
Name: olfactory receptor family 8 subfamily G member 18
Synonyms: MOR171-32P, GA_x6K02T2PVTD-32935684-32934749, K4, MOR171-41P, MOR171-32P, Olfr144, Olfr1537-ps1, Olfr1537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257959
VEGA: 9
HGNC: HGNC:8484
Homologene: 110610
A630023A22Rik
Name: RIKEN cDNA A630023A22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105518
VEGA: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 180,668,850 bp
  • A to G, chromosome 2 at 6,440,976 bp
  • T to A, chromosome 2 at 120,154,348 bp
  • A to G, chromosome 2 at 156,521,557 bp
  • T to A, chromosome 4 at 12,075,671 bp
  • A to G, chromosome 4 at 139,393,414 bp
  • T to C, chromosome 4 at 150,244,033 bp
  • T to C, chromosome 4 at 152,404,601 bp
  • T to A, chromosome 5 at 112,369,924 bp
  • C to A, chromosome 5 at 120,602,411 bp
  • T to C, chromosome 5 at 138,277,359 bp
  • A to G, chromosome 6 at 48,613,253 bp
  • A to G, chromosome 6 at 54,589,314 bp
  • A to T, chromosome 6 at 113,793,718 bp
  • A to G, chromosome 6 at 125,168,041 bp
  • C to A, chromosome 7 at 14,664,106 bp
  • A to G, chromosome 7 at 14,664,107 bp
  • A to G, chromosome 7 at 108,317,358 bp
  • G to A, chromosome 7 at 108,346,558 bp
  • A to C, chromosome 9 at 39,238,079 bp
  • A to G, chromosome 10 at 7,919,359 bp
  • C to A, chromosome 10 at 59,616,230 bp
  • A to G, chromosome 13 at 77,043,569 bp
  • T to C, chromosome 13 at 89,725,547 bp
  • C to T, chromosome 13 at 91,890,598 bp
  • T to A, chromosome 14 at 21,618,904 bp
  • A to G, chromosome 14 at 34,054,971 bp
  • A to C, chromosome 14 at 37,082,939 bp
  • G to A, chromosome 15 at 4,735,139 bp
  • T to C, chromosome 15 at 41,103,544 bp
  • A to T, chromosome 15 at 85,120,647 bp
  • C to T, chromosome 15 at 89,099,459 bp
  • T to A, chromosome 16 at 44,451,853 bp
  • G to A, chromosome 17 at 28,313,548 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4178 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040864-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.