Strain Name:
C57BL/6J-MtgxR3816Btlr/Mmmh
Stock Number:
040881-MU
Citation ID:
RRID:MMRRC_040881-MU
Other Names:
R3816 (G1), C57BL/6J-MtgxR3816Btlr
Major Collection:

Strain Information

Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: D16Jhu34, 410I21.SP6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Dock1
Name: dedicator of cytokinesis 1
Synonyms: Dock180, b2b3190Clo, 9130006G06Rik, D630004B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Arl8b
Name: ADP-ribosylation factor-like 8B
Synonyms: 3100002J04Rik, 2610313E07Rik, Arl10c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67166
Homologene: 10056
Phf3
Name: PHD finger protein 3
Synonyms: AU020177, 2310061N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24128
Homologene: 6927
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58198
Homologene: 2230
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: P27, Bridge-1, 1500011J20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Ass1
Name: argininosuccinate synthetase 1
Synonyms: fold, ASS, Ass-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: Sorla, LR11, mSorLA, 2900010L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Hapstr1
Name: HUWE1 associated protein modifying stress responses
Synonyms: 1810013L24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69053
VEGA: 16
Homologene: 105712
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69792
Homologene: 3990
Glipr2
Name: GLI pathogenesis-related 2
Synonyms: GAPR-1, 5730414A08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 384009
Homologene: 74720
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68273
Homologene: 9806
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: 2200002N01Rik, Semcap2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54120
Homologene: 22994
Rac2
Name: Rac family small GTPase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19354
VEGA: 15
HGNC: HGNC:9802
Homologene: 55699
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: A930014J19Rik, DMPK-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Pcdhb4
Name: protocadherin beta 4
Synonyms: PcdhbD, Pcdhb5A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Agfg2
Name: ArfGAP with FG repeats 2
Synonyms: Hrbl, A630095P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231801
HGNC: HGNC:5177
Homologene: 4430
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Gsdme
Name: gasdermin E
Synonyms: 4932441K13Rik, Fin15, 2310037D07Rik, Dfna5h, Dfna5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 632671
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435626
Homologene: 52359
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235441
Homologene: 4766
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213234
Homologene: 11661
Ifi44
Name: interferon-induced protein 44
Synonyms: MTAP44, p44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Gabrg3
Name: gamma-aminobutyric acid type A receptor, subunit gamma 3
Synonyms: B230362M20Rik, Gabrg-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14407
HGNC: HGNC:4088
Homologene: 22444
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21934
Homologene: 2848
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13118
Homologene: 134044
Or8b40
Name: olfactory receptor family 8 subfamily B member 40
Synonyms: MOR162-2, GA_x6K02T2PVTD-31795028-31795957, Olfr889
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258475
Homologene: 138311
H2-M10.2
Name: histocompatibility 2, M region locus 10.2
Synonyms: 4.7H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 333715
Homologene: 117973
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Or2ag18
Name: olfactory receptor family 2 subfamily AG member 18
Synonyms: MOR283-4, GA_x6K02T2PBJ9-9184187-9183237, Olfr700
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258593
Homologene: 64895
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il18ralpha, Il1rrp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Ly9
Name: lymphocyte antigen 9
Synonyms: SLAMF3, CD229, Lgp100, T100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Or5p59
Name: olfactory receptor family 5 subfamily P member 59
Synonyms: MOR204-12, GA_x6K02T2PBJ9-10432095-10433042, Olfr483
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258730
Homologene: 133602
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: MMCM2, MMSpi2, D12Rp54, contrapsin, Spi2, RP54, 1300001I07Rik, Spi-2, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Star
Name: steroidogenic acute regulatory protein
Synonyms: D8Ertd419e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20845
Homologene: 297
E130018O15Rik
Name: RIKEN cDNA E130018O15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 442795
Or8b12c
Name: olfactory receptor family 8 subfamily B member 12C
Synonyms: GA_x6K02T2PVTD-31489645-31490577, Olfr876, MOR161-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258883
Homologene: 74154
Khk
Name: ketohexokinase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16548
HGNC: HGNC:6315
Homologene: 38187
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: Cdc91l1, 5430426F17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228812
Homologene: 6553
Or8b55
Name: olfactory receptor family 8 subfamily B member 55
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3, Olfr922
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
As3mt
Name: arsenite methyltransferase
Synonyms: Cyt19, 2310045H08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57344
VEGA: 19
Homologene: 10754
Ostb
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: c-Flip, 2310024N18Rik, Casper, Flip, Cash, A430105C05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
Gjb2
Name: gap junction protein, beta 2
Synonyms: Cx26, Gjb-2, connexin 26
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14619
HGNC: HGNC:4284
Homologene: 2975
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,805,753 bp
  • T to C, chromosome 1 at 40,486,972 bp
  • T to C, chromosome 1 at 58,752,423 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • C to T, chromosome 1 at 105,809,360 bp
  • G to T, chromosome 1 at 171,589,085 bp
  • A to G, chromosome 1 at 180,144,886 bp
  • A to G, chromosome 2 at 25,446,071 bp
  • G to T, chromosome 2 at 31,510,105 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • G to A, chromosome 2 at 147,028,200 bp
  • A to T, chromosome 2 at 155,299,143 bp
  • G to T, chromosome 3 at 75,085,495 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 3 at 151,749,257 bp
  • T to C, chromosome 3 at 152,165,844 bp
  • G to T, chromosome 4 at 43,977,522 bp
  • A to G, chromosome 4 at 113,629,122 bp
  • A to T, chromosome 4 at 115,432,470 bp
  • T to A, chromosome 4 at 116,153,942 bp
  • T to C, chromosome 5 at 30,926,716 bp
  • T to C, chromosome 5 at 35,382,766 bp
  • T to A, chromosome 5 at 89,705,264 bp
  • C to T, chromosome 5 at 123,234,590 bp
  • T to C, chromosome 5 at 137,653,774 bp
  • T to C, chromosome 5 at 151,561,683 bp
  • A to T, chromosome 6 at 48,481,103 bp
  • A to C, chromosome 6 at 50,219,411 bp
  • T to C, chromosome 6 at 86,959,042 bp
  • T to A, chromosome 6 at 108,813,697 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • G to A, chromosome 7 at 57,381,664 bp
  • A to G, chromosome 7 at 106,805,820 bp
  • A to G, chromosome 7 at 108,103,498 bp
  • A to G, chromosome 7 at 120,800,379 bp
  • C to T, chromosome 7 at 134,744,286 bp
  • C to T, chromosome 8 at 16,002,522 bp
  • G to A, chromosome 8 at 25,809,877 bp
  • G to T, chromosome 8 at 89,032,675 bp
  • C to T, chromosome 9 at 37,804,169 bp
  • A to T, chromosome 9 at 38,116,626 bp
  • A to G, chromosome 9 at 38,816,426 bp
  • A to G, chromosome 9 at 42,064,049 bp
  • T to C, chromosome 9 at 53,569,916 bp
  • A to G, chromosome 9 at 65,414,018 bp
  • A to G, chromosome 9 at 66,527,034 bp
  • C to T, chromosome 9 at 119,124,843 bp
  • A to G, chromosome 11 at 6,510,926 bp
  • A to G, chromosome 11 at 84,994,384 bp
  • T to C, chromosome 12 at 51,785,969 bp
  • C to T, chromosome 12 at 81,589,085 bp
  • A to G, chromosome 12 at 104,340,962 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • A to G, chromosome 14 at 57,100,073 bp
  • T to C, chromosome 15 at 78,565,999 bp
  • T to A, chromosome 16 at 8,830,494 bp
  • C to A, chromosome 16 at 32,754,529 bp
  • A to G, chromosome 16 at 94,133,088 bp
  • A to T, chromosome 17 at 36,286,362 bp
  • A to T, chromosome 18 at 37,308,012 bp
  • A to G, chromosome 18 at 61,078,945 bp
  • A to T, chromosome 19 at 46,707,777 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3816 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040881-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.