Strain Name:
C57BL/6J-MtgxR3816Btlr/Mmmh
Stock Number:
040881-MU
Citation ID:
RRID:MMRRC_040881-MU
Other Names:
R3816 (G1), C57BL/6J-MtgxR3816Btlr
Major Collection:

Gene Information

Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: 410I21.SP6, D16Jhu34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Arl8b
Name: ADP-ribosylation factor-like 8B
Synonyms: 3100002J04Rik, 2610313E07Rik, Arl10c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67166
Homologene: 10056
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237898
Homologene: 13066
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24128
Homologene: 6927
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 58198
Homologene: 2230
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: P27, 1500011J20Rik, Bridge-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Ass1
Name: argininosuccinate synthetase 1
Synonyms: ASS, Ass-1, fold
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: CD140b, Pdgfr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Aak1
Name: AP2 associated kinase 1
Synonyms: 5530400K14Rik, D6Ertd245e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269774
Homologene: 128746
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
1810013L24Rik
Name: RIKEN cDNA 1810013L24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69053
VEGA: 16
Homologene: 105712
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69792
Homologene: 3990
Glipr2
Name: GLI pathogenesis-related 2
Synonyms: GAPR-1, 5730414A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 384009
Homologene: 74720
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68273
Homologene: 9806
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: 2200002N01Rik, Semcap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54120
Homologene: 22994
Rac2
Name: Rac family small GTPase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19354
VEGA: 15
HGNC: HGNC:9802
Homologene: 55699
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: DMPK-like, A930014J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Pcdhb4
Name: protocadherin beta 4
Synonyms: Pcdhb5A, PcdhbD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93875
Homologene: 62176
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Agfg2
Name: ArfGAP with FG repeats 2
Synonyms: A630095P14Rik, Hrbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231801
HGNC: HGNC:5177
Homologene: 4430
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233813
Homologene: 18607
Adamts3
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Gsdme
Name: gasdermin E
Synonyms: 4932441K13Rik, 2310037D07Rik, Fin15, Dfna5h, Dfna5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 632671
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Abca2
Name: ATP-binding cassette, sub-family A (ABC1), member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235441
Homologene: 4766
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213234
Homologene: 11661
Ifi44
Name: interferon-induced protein 44
Synonyms: p44, MTAP44, A430056A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99899
Homologene: 4683
Gabrg3
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3
Synonyms: Gabrg-3, B230362M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14407
HGNC: HGNC:4088
Homologene: 22444
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13118
Homologene: 134044
Olfr889
Name: olfactory receptor 889
Synonyms: GA_x6K02T2PVTD-31795028-31795957, MOR162-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258475
Homologene: 138311
H2-M10.2
Name: histocompatibility 2, M region locus 10.2
Synonyms: 4.7H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 333715
Homologene: 117973
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Olfr700
Name: olfactory receptor 700
Synonyms: GA_x6K02T2PBJ9-9184187-9183237, MOR283-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258593
Homologene: 64895
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Ly9
Name: lymphocyte antigen 9
Synonyms: T100, Lgp100, CD229, SLAMF3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Olfr483
Name: olfactory receptor 483
Synonyms: GA_x6K02T2PBJ9-10432095-10433042, MOR204-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258730
Homologene: 133602
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: contrapsin, Spi-2, D12Rp54, RP54, Spi2, MMSpi2, MMCM2, alpha-1 antiproteinase, 1300001I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Star
Name: steroidogenic acute regulatory protein
Synonyms: D8Ertd419e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20845
Homologene: 297
E130018O15Rik
Name: RIKEN cDNA E130018O15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 442795
Olfr876
Name: olfactory receptor 876
Synonyms: GA_x6K02T2PVTD-31489645-31490577, MOR161-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258883
Homologene: 74154
Khk
Name: ketohexokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16548
HGNC: HGNC:6315
Homologene: 38187
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: 5430426F17Rik, Cdc91l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228812
Homologene: 6553
Olfr922
Name: olfactory receptor 922
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
As3mt
Name: arsenite methyltransferase
Synonyms: Cyt19, 2310045H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 57344
VEGA: 19
Homologene: 10754
Ostb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: Casper, A430105C05Rik, Flip, c-Flip, 2310024N18Rik, Cash
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
Gjb2
Name: gap junction protein, beta 2
Synonyms: connexin 26, Cx26, Gjb-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14619
HGNC: HGNC:4284
Homologene: 2975
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,805,753 bp
  • T to C, chromosome 1 at 40,486,972 bp
  • T to C, chromosome 1 at 58,752,423 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • C to T, chromosome 1 at 105,809,360 bp
  • G to T, chromosome 1 at 171,589,085 bp
  • A to G, chromosome 1 at 180,144,886 bp
  • A to G, chromosome 2 at 25,446,071 bp
  • G to T, chromosome 2 at 31,510,105 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • G to A, chromosome 2 at 147,028,200 bp
  • A to T, chromosome 2 at 155,299,143 bp
  • G to T, chromosome 3 at 75,085,495 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 3 at 151,749,257 bp
  • T to C, chromosome 3 at 152,165,844 bp
  • G to T, chromosome 4 at 43,977,522 bp
  • A to G, chromosome 4 at 113,629,122 bp
  • A to T, chromosome 4 at 115,432,470 bp
  • T to A, chromosome 4 at 116,153,942 bp
  • T to C, chromosome 5 at 30,926,716 bp
  • T to C, chromosome 5 at 35,382,766 bp
  • T to A, chromosome 5 at 89,705,264 bp
  • C to T, chromosome 5 at 123,234,590 bp
  • T to C, chromosome 5 at 137,653,774 bp
  • T to C, chromosome 5 at 151,561,683 bp
  • A to T, chromosome 6 at 48,481,103 bp
  • A to C, chromosome 6 at 50,219,411 bp
  • T to C, chromosome 6 at 86,959,042 bp
  • T to A, chromosome 6 at 108,813,697 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • G to A, chromosome 7 at 57,381,664 bp
  • A to G, chromosome 7 at 106,805,820 bp
  • A to G, chromosome 7 at 108,103,498 bp
  • A to G, chromosome 7 at 120,800,379 bp
  • C to T, chromosome 7 at 134,744,286 bp
  • C to T, chromosome 8 at 16,002,522 bp
  • G to A, chromosome 8 at 25,809,877 bp
  • G to T, chromosome 8 at 89,032,675 bp
  • C to T, chromosome 9 at 37,804,169 bp
  • A to T, chromosome 9 at 38,116,626 bp
  • A to G, chromosome 9 at 38,816,426 bp
  • A to G, chromosome 9 at 42,064,049 bp
  • T to C, chromosome 9 at 53,569,916 bp
  • A to G, chromosome 9 at 65,414,018 bp
  • A to G, chromosome 9 at 66,527,034 bp
  • C to T, chromosome 9 at 119,124,843 bp
  • A to G, chromosome 11 at 6,510,926 bp
  • A to G, chromosome 11 at 84,994,384 bp
  • T to C, chromosome 12 at 51,785,969 bp
  • C to T, chromosome 12 at 81,589,085 bp
  • A to G, chromosome 12 at 104,340,962 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • A to G, chromosome 14 at 57,100,073 bp
  • T to C, chromosome 15 at 78,565,999 bp
  • T to A, chromosome 16 at 8,830,494 bp
  • C to A, chromosome 16 at 32,754,529 bp
  • A to G, chromosome 16 at 94,133,088 bp
  • A to T, chromosome 17 at 36,286,362 bp
  • A to T, chromosome 18 at 37,308,012 bp
  • A to G, chromosome 18 at 61,078,945 bp
  • A to T, chromosome 19 at 46,707,777 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3816 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040881-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.