Strain Name:
C57BL/6J-MtgxR3820Btlr/Mmmh
Stock Number:
040882-MU
Citation ID:
RRID:MMRRC_040882-MU
Other Names:
R3820 (G1), C57BL/6J-MtgxR3820Btlr
Major Collection:

Gene Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: 1110061A24Rik, RII(alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: b2b1562Clo, my, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242022
Homologene: 18454
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: Prkcbp1, ZMYND8, RACK7, 3632413B07Rik, 1110013E22Rik, 2010005I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Her-2 Tg, WAP-Her-2, AS3, Tg(Wap-ERBB2)229Wzw, Aprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100710
Homologene: 41001
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 170750
Homologene: 6424
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Cnot6
Name: CCR4-NOT transcription complex, subunit 6
Synonyms: A230103N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104625
Homologene: 69187
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 212281
Homologene: 133713
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71521
Homologene: 22877
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 104831
Homologene: 135706
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 4633402D15Rik, 9230102M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70829
Homologene: 10393
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229227
Homologene: 52105
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, 2610040L17Rik, Ten-m2, Odz2, 9330187F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23964
Homologene: 22672
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: 2810011H21Rik, D12Ertd549e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69684
Homologene: 6821
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 319262
Homologene: 14127
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: LTRPC3, 6330504P12Rik, MLSN2, melastatin 2, B930001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226025
VEGA: 19
Homologene: 62287
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: AIB3, RAP250, PRIP, NRC, ASC2, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56406
Homologene: 137337
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, Flt-1, VEGFR1, sFlt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, 1500037O19Rik, D9Ertd414e, Unc13h3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208898
Homologene: 45443
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, 1810073P09Rik, ESTM15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 75607
Homologene: 19155
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 214575
Homologene: 18312
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16564
VEGA: 15
Homologene: 56761
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: GluN2A, NMDAR2A, GluRepsilon1, NR2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, C030030G16Rik, Slack
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227632
Homologene: 11055
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, BKCa, Slo, BK channel alpha subunit, MaxiK, Slo1, mSlo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Edar
Name: ectodysplasin-A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13608
HGNC: HGNC:2895
Homologene: 7699
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 272381
Homologene: 45681
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238405
Homologene: 128362
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: DFF40, CAD, CPAN, caspase-activated DNase, 40kDa, Didff, 5730477D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384220
Homologene: 104825
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 637898
Homologene: 129683
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Fam196b, Gm6041
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 574403
VEGA: 11
Homologene: 107175
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242409
Homologene: 72894
Arhgap22
Name: Rho GTPase activating protein 22
Synonyms: RHOGAP2, B230341L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239027
Homologene: 23292
Ido2
Name: indoleamine 2,3-dioxygenase 2
Synonyms: C230043N17Rik, Ido2, Indol1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 209176
Homologene: 48830
Abcd2
Name: ATP-binding cassette, sub-family D (ALD), member 2
Synonyms: adrenoleukodystrophy related, ALDL1, ABC39, ALDR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
4921524L21Rik
Name: RIKEN cDNA 4921524L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 70901
VEGA: 18
Homologene: 78009
Micall2
Name: MICAL-like 2
Synonyms: Jrab, A930021H16Rik, MICAL-L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231830
Homologene: 85155
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 319848
Homologene: 21127
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 106,875,072 bp
  • T to C, chromosome 1 at 121,462,240 bp
  • A to G, chromosome 1 at 156,285,483 bp
  • A to G, chromosome 2 at 25,900,892 bp
  • T to A, chromosome 2 at 155,406,938 bp
  • T to A, chromosome 2 at 165,815,461 bp
  • G to A, chromosome 3 at 37,040,434 bp
  • T to A, chromosome 3 at 53,516,849 bp
  • C to A, chromosome 4 at 43,689,745 bp
  • C to A, chromosome 4 at 153,972,768 bp
  • A to G, chromosome 5 at 32,828,984 bp
  • A to G, chromosome 5 at 65,654,076 bp
  • C to T, chromosome 5 at 109,362,277 bp
  • C to T, chromosome 5 at 139,715,856 bp
  • A to G, chromosome 5 at 147,700,017 bp
  • T to C, chromosome 5 at 150,736,337 bp
  • A to T, chromosome 7 at 42,135,701 bp
  • T to A, chromosome 7 at 44,462,558 bp
  • T to C, chromosome 8 at 24,533,755 bp
  • A to T, chromosome 9 at 73,930,958 bp
  • T to G, chromosome 9 at 108,746,956 bp
  • A to G, chromosome 9 at 110,389,794 bp
  • T to C, chromosome 10 at 58,621,363 bp
  • T to C, chromosome 11 at 34,403,007 bp
  • A to T, chromosome 11 at 36,024,320 bp
  • A to T, chromosome 11 at 49,689,172 bp
  • C to A, chromosome 11 at 65,851,003 bp
  • T to A, chromosome 11 at 101,411,145 bp
  • C to A, chromosome 11 at 104,633,612 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • A to T, chromosome 12 at 111,540,184 bp
  • C to T, chromosome 12 at 113,490,364 bp
  • T to C, chromosome 12 at 113,544,178 bp
  • C to T, chromosome 13 at 23,901,769 bp
  • A to T, chromosome 13 at 42,184,311 bp
  • G to A, chromosome 13 at 49,102,777 bp
  • A to T, chromosome 13 at 67,621,319 bp
  • T to C, chromosome 14 at 23,299,938 bp
  • G to A, chromosome 14 at 33,367,421 bp
  • G to A, chromosome 14 at 55,100,573 bp
  • T to C, chromosome 15 at 90,968,074 bp
  • C to T, chromosome 15 at 91,174,705 bp
  • A to G, chromosome 16 at 9,644,088 bp
  • C to A, chromosome 17 at 67,779,046 bp
  • C to A, chromosome 17 at 83,473,065 bp
  • G to T, chromosome 18 at 6,630,166 bp
  • A to G, chromosome 18 at 37,969,457 bp
  • A to T, chromosome 19 at 22,987,449 bp
  • G to A, chromosome 19 at 53,003,819 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3820 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040882-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.