Strain Name:
C57BL/6J-MtgxR3845Btlr/Mmmh
Stock Number:
040893-MU
Citation ID:
RRID:MMRRC_040893-MU
Other Names:
R3845 (G1), C57BL/6J-MtgxR3845Btlr
Major Collection:

Gene Information

Pias3
Name: protein inhibitor of activated STAT 3
Synonyms: Pias3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229615
Homologene: 4447
Sfrp1
Name: secreted frizzled-related protein 1
Synonyms: sFRP-1, 2210415K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20377
Homologene: 2266
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73884
Homologene: 52868
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Rev1
Name: REV1, DNA directed polymerase
Synonyms: REV1, 1110027I23Rik, Rev1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56210
Homologene: 32309
Usp15
Name: ubiquitin specific peptidase 15
Synonyms: Gcap18, 4921514G19Rik, E430033I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14479
VEGA: 10
Homologene: 101542
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235559
Homologene: 38262
Apool
Name: apolipoprotein O-like
Synonyms: E130106L15Rik, 6720473G16Rik, 9430083G14Rik, Micos27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 68117
Homologene: 57144
Mtch1
Name: mitochondrial carrier 1
Synonyms: 2310034O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56462
Homologene: 22807
Ptk7
Name: PTK7 protein tyrosine kinase 7
Synonyms: 8430404F20Rik, mPTK7/CCK4, chz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71461
VEGA: 17
HGNC: HGNC:9618
Homologene: 43672
Ctps
Name: cytidine 5'-triphosphate synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Foxo1
Name: forkhead box O1
Synonyms: FKHR, Fkhr1, Afxh, Foxo1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Tent4b
Name: terminal nucleotidyltransferase 4B
Synonyms: 5730445M16Rik, Papd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 214627
Homologene: 64245
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216177
Homologene: 87560
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217653
Homologene: 10147
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Krt19
Name: keratin 19
Synonyms: K19, EndoC, cytokeratin-19, cytokeratin19, cytokeratin 19, Krt-1.19, Krt1-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16669
HGNC: HGNC:6436
Homologene: 1713
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Hyk, Tie2, Cd202b, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21687
Homologene: 397
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 53867
Homologene: 9253
Trim16
Name: tripartite motif-containing 16
Synonyms: EBBP, 9130006M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94092
Homologene: 4726
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Slc5a4a
Name: solute carrier family 5, member 4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64452
VEGA: 10
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Ccdc97
Name: coiled-coil domain containing 97
Synonyms: 2810446P04Rik, 1200014H14Rik, D7Ertd462e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52132
Homologene: 32701
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Thbs2
Name: thrombospondin 2
Synonyms: TSP2, Thbs-2, Thrombospondin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Ccdc105
Name: coiled-coil domain containing 105
Synonyms: 4931413A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: GluRdelta2, tpr, B230104L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67155
Homologene: 2308
Olfr1024
Name: olfactory receptor 1024
Synonyms: GA_x6K02T2Q125-47384320-47383337, MOR197-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257900
Homologene: 128271
Tmem38b
Name: transmembrane protein 38B
Synonyms: 1600017F22Rik, D4Ertd89e, TRIC-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52076
Homologene: 10010
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381569
Homologene: 77858
Upf3a
Name: UPF3 regulator of nonsense transcripts homolog A (yeast)
Synonyms: 4930546M19Rik, RENT3A, UPF3, 2600001C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67031
Homologene: 23395
Nhej1
Name: non-homologous end joining factor 1
Synonyms: 1700029B21Rik, XLF, cernunnos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75570
Homologene: 11714
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Gm7196, Vmn2r-ps113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 637021
Homologene: 115024
Pltp
Name: phospholipid transfer protein
Synonyms: OD107, Bpife
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18830
HGNC: HGNC:9093
Homologene: 4536
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232664
Homologene: 23378
Kcnk10
Name: potassium channel, subfamily K, member 10
Synonyms: 3010005K24Rik, 1700024D23Rik, Trek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72258
VEGA: 12
HGNC: HGNC:6273
Homologene: 11321
Inca1
Name: inhibitor of CDK, cyclin A1 interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103844
Homologene: 19481
Tas2r109
Name: taste receptor, type 2, member 109
Synonyms: T2R09, Tas2r9, mGR09, mt2r62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387343
Homologene: 87292
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Rtkn2
Name: rhotekin 2
Synonyms: B130039D23Rik, RTKN2, Mbf, Plekhk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170799
Homologene: 17065
Cpn1
Name: carboxypeptidase N, polypeptide 1
Synonyms: CPN, 50 kDa, 0610011F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93721
HGNC: HGNC:2312
Homologene: 1002
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 38,098,988 bp
  • A to T, chromosome 1 at 63,308,324 bp
  • A to T, chromosome 1 at 74,968,883 bp
  • A to G, chromosome 1 at 181,112,405 bp
  • A to G, chromosome 1 at 194,793,790 bp
  • T to C, chromosome 2 at 13,283,008 bp
  • A to C, chromosome 2 at 85,904,737 bp
  • T to C, chromosome 2 at 91,009,238 bp
  • T to A, chromosome 2 at 164,854,288 bp
  • T to A, chromosome 3 at 52,346,280 bp
  • A to G, chromosome 3 at 56,086,292 bp
  • T to C, chromosome 3 at 96,702,210 bp
  • T to A, chromosome 4 at 53,859,905 bp
  • T to A, chromosome 4 at 94,804,872 bp
  • A to T, chromosome 4 at 120,542,636 bp
  • T to C, chromosome 4 at 143,811,975 bp
  • C to T, chromosome 6 at 29,417,177 bp
  • A to G, chromosome 6 at 64,345,842 bp
  • G to A, chromosome 6 at 132,980,803 bp
  • G to A, chromosome 7 at 16,907,386 bp
  • T to C, chromosome 7 at 25,715,028 bp
  • A to G, chromosome 7 at 30,717,115 bp
  • A to T, chromosome 8 at 13,798,238 bp
  • T to C, chromosome 8 at 23,412,248 bp
  • T to C, chromosome 8 at 43,626,632 bp
  • A to T, chromosome 8 at 88,250,664 bp
  • C to T, chromosome 9 at 20,808,377 bp
  • T to C, chromosome 9 at 103,309,923 bp
  • T to C, chromosome 10 at 68,003,336 bp
  • A to G, chromosome 10 at 76,189,149 bp
  • T to C, chromosome 10 at 78,748,698 bp
  • T to A, chromosome 10 at 82,151,318 bp
  • T to C, chromosome 10 at 109,853,376 bp
  • A to G, chromosome 10 at 123,119,135 bp
  • T to G, chromosome 11 at 62,836,672 bp
  • T to A, chromosome 11 at 67,259,105 bp
  • T to C, chromosome 11 at 69,346,759 bp
  • C to T, chromosome 11 at 70,690,564 bp
  • T to C, chromosome 11 at 100,141,514 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • G to A, chromosome 12 at 65,149,142 bp
  • T to C, chromosome 12 at 70,198,443 bp
  • A to G, chromosome 12 at 98,440,744 bp
  • A to T, chromosome 13 at 64,089,062 bp
  • T to A, chromosome 15 at 4,900,521 bp
  • A to G, chromosome 17 at 14,678,918 bp
  • T to A, chromosome 17 at 18,073,691 bp
  • G to A, chromosome 17 at 18,107,598 bp
  • A to T, chromosome 17 at 29,342,832 bp
  • A to T, chromosome 17 at 46,586,418 bp
  • A to G, chromosome 19 at 26,720,873 bp
  • G to T, chromosome 19 at 43,974,084 bp
  • A to T, chromosome X at 112,364,458 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3845 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040893-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.