Strain Name:
C57BL/6J-MtgxR3853Btlr/Mmmh
Stock Number:
040900-MU
Citation ID:
RRID:MMRRC_040900-MU
Other Names:
R3853 (G1), C57BL/6J-MtgxR3853Btlr
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Usp9x
Name: ubiquitin specific peptidase 9, X chromosome
Synonyms: Dffrx, Fafl, 5730589N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22284
Homologene: 3418
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: wolframin, Wolfram syndrome 1 homolog (human)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22393
Homologene: 4380
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Par-1, Emk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Trim36
Name: tripartite motif-containing 36
Synonyms: D18Wsu100e, Haprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Exo1
Name: exonuclease 1
Synonyms: Msa, 5730442G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26909
HGNC: HGNC:3511
Homologene: 31352
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100683
Homologene: 39246
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Cluh
Name: clustered mitochondria (cluA/CLU1) homolog
Synonyms: 1300001I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74148
Homologene: 9063
Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269608
Homologene: 10768
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, 1A1, Klkbp, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Trap1
Name: TNF receptor-associated protein 1
Synonyms: HSP75, 2410002K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68015
Homologene: 9457
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: CCCAP, 2700048G21Rik, 5730470G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76816
Homologene: 4839
Gjc1
Name: gap junction protein, gamma 1
Synonyms: connexin 45, Cx45, Gja-7, C130009G16Rik, Gja7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14615
HGNC: HGNC:4280
Homologene: 4016
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, mH2, SkM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110880
Homologene: 283
Trmt2a
Name: TRM2 tRNA methyltransferase 2A
Synonyms: Htf9c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15547
Homologene: 7374
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72094
Homologene: 55988
Prkce
Name: protein kinase C, epsilon
Synonyms: PKC[e], Pkce, 5830406C15Rik, PKCepsilon, PCK epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Shoc1
Name: shortage in chiasmata 1
Synonyms: LOC242489, Gm426, AI481877, Mzip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100155
Homologene: 79783
CAAA01180111.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Or4a71
Name: olfactory receptor family 4 subfamily A member 71
Synonyms: GA_x6K02T2Q125-50972538-50971621, MOR231-4, Olfr1243
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258971
Homologene: 27317
Tmem132c
Name: transmembrane protein 132C
Synonyms: 4632425D07Rik, 2810482M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208213
Homologene: 76567
Rad21
Name: RAD21 cohesin complex component
Synonyms: SCC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19357
VEGA: 15
HGNC: HGNC:9811
Homologene: 38161
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: EVER1, D11Ertd204e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217353
Homologene: 5258
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244962
Homologene: 17823
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: ovalbumin, PI-9, Spi6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Or10g7
Name: olfactory receptor family 10 subfamily G member 7
Synonyms: GA_x6K02T2PVTD-33692287-33693222, MOR223-3, Olfr978
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259109
VEGA: 9
Homologene: 88420
Tsnaxip1
Name: translin-associated factor X (Tsnax) interacting protein 1
Synonyms: TXI1, 1700016K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72236
Homologene: 10194
Or7a38
Name: olfactory receptor family 7 subfamily A member 38
Synonyms: GA_x6K02T03FR9-4826-3919, GA_x6K02T2QGN0-2895081-2894349, MOR185-8, MOR139-7, MOR139-5, EG257869, Olfr233-ps1, Olfr1354
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 259163
Homologene: 136441
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Nol4l
Name: nucleolar protein 4-like
Synonyms: LOC381396, 8430427H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329540
Homologene: 129589
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67538
Homologene: 15436
Eya4
Name: EYA transcriptional coactivator and phosphatase 4
Synonyms: B130023L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14051
VEGA: 10
HGNC: HGNC:3522
Homologene: 3025
Padi3
Name: peptidyl arginine deiminase, type III
Synonyms: PAD type III, Pad3, Pdi3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18601
Homologene: 7882
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Pwwp3b
Name: PWWP domain containing 3B
Synonyms: 9430086K21Rik, Mum1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245631
Homologene: 51851
Or5b112
Name: olfactory receptor family 5 subfamily B member 112
Synonyms: GA_x6K02T2RE5P-3672907-3673839, MOR202-12, Olfr1466
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258689
HGNC: HGNC:8324
Homologene: 133677
Or8b1
Name: olfactory receptor family 8 subfamily B member 1
Synonyms: GA_x6K02T2PVTD-32194085-32195020, MOR167-2, Olfr906
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Sebox
Name: SEBOX homeobox
Synonyms: OG9, Og9x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18292
Homologene: 32052
Hcar2
Name: hydroxycarboxylic acid receptor 2
Synonyms: PUMA-G, HM74, Pumag, Gpr109b, Gpr109a, Niacr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80885
Homologene: 4391
Mbd3l2
Name: methyl-CpG binding domain protein 3-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234988
VEGA: 9
Homologene: 44896
Lce3e
Name: late cornified envelope 3E
Synonyms: 2310001H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69514
Homologene: 134278
Ifna15
Name: interferon alpha 15
Synonyms: Ifnaa, Gm12597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242517
Homologene: 68536
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 175,892,988 bp
  • T to C, chromosome 1 at 176,853,795 bp
  • A to T, chromosome 2 at 89,527,573 bp
  • A to G, chromosome 2 at 153,416,632 bp
  • A to G, chromosome 2 at 164,820,857 bp
  • C to T, chromosome 3 at 92,967,832 bp
  • T to C, chromosome 4 at 59,047,390 bp
  • T to C, chromosome 4 at 88,557,809 bp
  • T to C, chromosome 4 at 140,791,269 bp
  • C to T, chromosome 4 at 152,114,823 bp
  • C to A, chromosome 5 at 36,968,624 bp
  • A to T, chromosome 5 at 87,337,159 bp
  • T to C, chromosome 5 at 123,864,412 bp
  • T to C, chromosome 5 at 127,359,869 bp
  • A to C, chromosome 5 at 137,474,064 bp
  • A to G, chromosome 5 at 144,792,165 bp
  • A to G, chromosome 7 at 114,223,316 bp
  • A to C, chromosome 7 at 135,696,130 bp
  • A to T, chromosome 8 at 105,840,701 bp
  • A to G, chromosome 9 at 18,444,796 bp
  • G to T, chromosome 9 at 38,488,951 bp
  • A to T, chromosome 9 at 39,994,154 bp
  • T to C, chromosome 9 at 88,407,319 bp
  • T to A, chromosome 9 at 124,293,346 bp
  • C to T, chromosome 10 at 23,116,676 bp
  • T to A, chromosome 10 at 78,916,947 bp
  • T to C, chromosome 11 at 60,707,249 bp
  • A to G, chromosome 11 at 74,656,453 bp
  • G to A, chromosome 11 at 78,504,149 bp
  • G to T, chromosome 11 at 102,800,126 bp
  • A to T, chromosome 11 at 106,320,106 bp
  • A to T, chromosome 11 at 117,773,058 bp
  • G to T, chromosome 12 at 57,728,549 bp
  • G to A, chromosome 12 at 104,148,300 bp
  • A to G, chromosome 13 at 33,015,520 bp
  • A to G, chromosome 14 at 12,509,090 bp
  • T to A, chromosome 14 at 55,864,105 bp
  • T to G, chromosome 15 at 51,972,316 bp
  • A to T, chromosome 15 at 75,837,497 bp
  • G to A, chromosome 16 at 4,054,822 bp
  • A to T, chromosome 16 at 18,251,191 bp
  • A to G, chromosome 17 at 86,168,849 bp
  • T to C, chromosome 18 at 20,449,234 bp
  • C to A, chromosome 18 at 46,172,372 bp
  • A to G, chromosome 19 at 7,277,290 bp
  • A to G, chromosome 19 at 13,342,498 bp
  • A to G, chromosome X at 13,098,583 bp
  • C to T, chromosome X at 139,236,654 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3853 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040900-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.