Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR3913Btlr/Mmmh
Stock Number:
040911-MU
Citation ID:
RRID:MMRRC_040911-MU
Other Names:
R3913 (G1), C57BL/6J-MtgxR3913Btlr
Major Collection:

Gene Information

Sema4b
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Synonyms: Semac, SemC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20352
Homologene: 8426
Olfm1
Name: olfactomedin 1
Synonyms: Noelin 1, Pancortin 1-4, Noelin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56177
Homologene: 8612
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Eprs
Name: glutamyl-prolyl-tRNA synthetase
Synonyms: 2410081F06Rik, 3010002K18Rik, Qprs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328329
Homologene: 42094
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12695
Homologene: 72199
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: 4930554K12Rik, D130072O21Rik, mTNKS1, TANK1, tankyrase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 21951
Homologene: 18405
Setd2
Name: SET domain containing 2
Synonyms: KMT3A, 4921524K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235626
Homologene: 56493
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, D630005A10Rik, A430040A19Rik, Bruce, A430032G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12211
Homologene: 7248
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100929
Homologene: 7068
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: Adprtl1, VPARP, C030027K23Rik, E230037B21Rik, VAULT3, PH5P, p193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Arid1b
Name: AT rich interactive domain 1B (SWI-like)
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 239985
Homologene: 32344
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 27059
Homologene: 19064
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: 3930401K13Rik, Npac, 2810419J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74022
VEGA: 16
Homologene: 12525
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20658
Homologene: 10551
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99480
Homologene: 124162
Tubb3
Name: tubulin, beta 3 class III
Synonyms: Tuj1, 3200002H15Rik, betaIII-tubulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 22152
Homologene: 68503
Snap91
Name: synaptosomal-associated protein 91
Synonyms: 91kDa, F1-20, AP180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20616
Homologene: 8429
Robo2
Name: roundabout guidance receptor 2
Synonyms: 2600013A04Rik, 9430089E08Rik, D230004I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268902
Homologene: 43188
Rlim
Name: ring finger protein, LIM domain interacting
Synonyms: Ha1r, Rnf12, Rlim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 19820
Homologene: 7920
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 100502841
VEGA: 18
Homologene: 14575
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233552
Homologene: 32741
Maml1
Name: mastermind like transcriptional coactivator 1
Synonyms: Mam-1, D930008C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103806
Homologene: 8845
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 170643
Homologene: 10089
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv2, Ron, Fv-2, CDw136, friend virus susceptibility 2, PTK8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Liph
Name: lipase, member H
Synonyms: LPDLR, Lpdlr, PLA1B, mPA-PLA1, C130037N08Rik, D16Wsu119e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239759
VEGA: 16
Homologene: 71802
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 70885
Homologene: 10029
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242274
Homologene: 10817
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: PGC-1beta/ERRL1, 4631412G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 170826
Homologene: 15776
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217143
Homologene: 34917
Olfr1022
Name: olfactory receptor 1022
Synonyms: MOR196-1, GA_x6K02T2Q125-47347069-47348016
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258582
Homologene: 128086
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Zdhhc8
Name: zinc finger, DHHC domain containing 8
Synonyms: E330009O14Rik, Op53c05, D16H22S1738E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 27801
VEGA: 16
Homologene: 8363
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Rev, Sez4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75033
Homologene: 87251
Pate4
Name: prostate and testis expressed 4
Synonyms: 9530004K16Rik, SVS VII, Svs7, Pate-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 56872
Homologene: 49624
Olfr390
Name: olfactory receptor 390
Synonyms: GA_x6K02T2P1NL-3938806-3939741, MOR135-26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258344
HGNC: null
Homologene: 115483
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, Loh11cr2a, 5830475I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Sec14l5
Name: SEC14-like lipid binding 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 665119
VEGA: 16
Homologene: 96163
Adra1d
Name: adrenergic receptor, alpha 1d
Synonyms: Adra-1, Adra1, alpha1D-AR, Gpcr8, Adra1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11550
HGNC: HGNC:280
Homologene: 551
Krt90
Name: keratin 90
Synonyms: 4732456N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239673
Homologene: 72272
Kcnab2
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms: I2rf5, Kcnb3, I2rf5, F5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16498
HGNC: HGNC:6229
Homologene: 56492
Klhl30
Name: kelch-like 30
Synonyms: 4631423F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70788
Homologene: 18891
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22626
Homologene: 65865
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240084
Homologene: 10396
1700001C19Rik
Name: RIKEN cDNA 1700001C19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 75462
HGNC: null
Homologene: 129540
Kcnj15
Name: potassium inwardly-rectifying channel, subfamily J, member 15
Synonyms: Kir4.2, 4930414N08Rik, IRKK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16516
HGNC: HGNC:6261
Homologene: 1690
Adh7
Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Synonyms: Adh-3e, Adh3-t, Adh3, Adt-1, Adh3-e, Adh-3t, Adh4, IV ADH, Adh-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11529
HGNC: HGNC:256
Homologene: 37333
Cd209c
Name: CD209c antigen
Synonyms: mSIGNR2, SIGNR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 170776
HGNC: HGNC:1641
Homologene: 87186
Gpr132
Name: G protein-coupled receptor 132
Synonyms: G2a, G2 accumulation
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56696
VEGA: 12
Homologene: 8350
Dcun1d2
Name: DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102323
Homologene: 85990
Psme2
Name: proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Synonyms: PA28b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19188
HGNC: HGNC:9569
Homologene: 86889
Mettl4
Name: methyltransferase like 4
Synonyms: HsT661, 2410198H06Rik, A730091E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 76781
VEGA: 17
Homologene: 35305
Dcaf15
Name: DDB1 and CUL4 associated factor 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 212123
Homologene: 18182
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 75,128,922 bp
  • T to C, chromosome 1 at 91,359,444 bp
  • A to G, chromosome 1 at 158,667,642 bp
  • G to A, chromosome 1 at 185,379,742 bp
  • A to G, chromosome 2 at 28,208,174 bp
  • T to C, chromosome 2 at 85,868,771 bp
  • T to A, chromosome 2 at 131,562,155 bp
  • T to C, chromosome 3 at 86,084,776 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • T to C, chromosome 3 at 122,275,391 bp
  • T to A, chromosome 3 at 138,221,780 bp
  • G to A, chromosome 3 at 158,291,952 bp
  • A to G, chromosome 4 at 98,569,101 bp
  • A to G, chromosome 4 at 152,395,232 bp
  • T to A, chromosome 5 at 130,259,035 bp
  • A to G, chromosome 7 at 80,220,474 bp
  • A to G, chromosome 7 at 99,438,339 bp
  • A to G, chromosome 8 at 3,940,438 bp
  • A to C, chromosome 8 at 13,281,082 bp
  • A to T, chromosome 8 at 34,873,074 bp
  • T to A, chromosome 8 at 68,813,620 bp
  • T to C, chromosome 8 at 84,099,165 bp
  • A to G, chromosome 8 at 123,421,009 bp
  • C to T, chromosome 9 at 21,398,126 bp
  • C to A, chromosome 9 at 35,611,844 bp
  • T to C, chromosome 9 at 38,734,743 bp
  • A to G, chromosome 9 at 81,890,263 bp
  • T to C, chromosome 9 at 86,792,557 bp
  • G to A, chromosome 9 at 107,914,746 bp
  • C to T, chromosome 9 at 110,551,046 bp
  • T to A, chromosome 9 at 118,538,971 bp
  • A to G, chromosome 10 at 39,820,556 bp
  • T to C, chromosome 10 at 43,998,763 bp
  • T to C, chromosome 11 at 50,263,432 bp
  • G to T, chromosome 11 at 73,787,696 bp
  • A to T, chromosome 11 at 97,334,765 bp
  • C to T, chromosome 11 at 118,080,849 bp
  • C to A, chromosome 12 at 112,853,020 bp
  • A to G, chromosome 13 at 102,758,669 bp
  • A to G, chromosome 14 at 55,588,027 bp
  • A to G, chromosome 14 at 56,620,518 bp
  • G to A, chromosome 15 at 101,562,783 bp
  • A to G, chromosome 16 at 5,031,913 bp
  • A to G, chromosome 16 at 5,147,856 bp
  • A to G, chromosome 16 at 18,226,723 bp
  • G to T, chromosome 16 at 21,962,259 bp
  • A to T, chromosome 16 at 74,035,005 bp
  • A to T, chromosome 16 at 91,660,111 bp
  • C to T, chromosome 16 at 95,296,470 bp
  • A to G, chromosome 17 at 5,342,257 bp
  • T to C, chromosome 17 at 35,525,336 bp
  • AC to A, chromosome 17 at 47,433,423 bp
  • A to T, chromosome 17 at 74,573,613 bp
  • A to G, chromosome 17 at 94,740,532 bp
  • T to C, chromosome 18 at 61,311,376 bp
  • T to C, chromosome 18 at 77,997,384 bp
  • T to C, chromosome X at 103,962,661 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3913 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040911-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.