Strain Name:
C57BL/6J-MtgxR3933Btlr/Mmmh
Stock Number:
040920-MU
Citation ID:
RRID:MMRRC_040920-MU
Other Names:
R3933 (G1), C57BL/6J-MtgxR3933Btlr
Major Collection:

Gene Information

Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100502698
Homologene: 15687
Mbtd1
Name: mbt domain containing 1
Synonyms: hemp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103537
Homologene: 41185
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: 2210412K19Rik, d1401, alpha-ketoglutarate dehydrogenase, 2210403E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Ppp2ca
Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Synonyms: PP2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19052
HGNC: HGNC:9299
Homologene: 37660
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: 1200011N24Rik, optic atrophy 1, lilr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Ccdc6
Name: coiled-coil domain containing 6
Synonyms: 2810012H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76551
Homologene: 34786
Syngr2
Name: synaptogyrin 2
Synonyms: Clast2, cellugyrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20973
Homologene: 20987
Coch
Name: cochlin
Synonyms: Coch-5B2, D12H14S564E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Lepr
Name: leptin receptor
Synonyms: obl, leptin receptor gene-related protein, Leprb, Obr, LEPROT, OB-RGRP, Modb1, obese-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Acp6
Name: acid phosphatase 6, lysophosphatidic
Synonyms: mPACPL1, 5730559A09Rik, ACPL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66659
Homologene: 41128
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74369
Homologene: 46535
Prune2
Name: prune homolog 2
Synonyms: A230083H22Rik, A330102H22Rik, 6330414G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, per, Plc, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Fut8
Name: fucosyltransferase 8
Synonyms: alpha (1,6) fucosyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 53618
VEGA: 12
HGNC: HGNC:4019
Homologene: 9650
Pold3
Name: polymerase (DNA-directed), delta 3, accessory subunit
Synonyms: GC12, C85233, 2410142G14Rik, P66, P68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67967
Homologene: 38202
Tatdn3
Name: TatD DNase domain containing 3
Synonyms: 1500010M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68972
Homologene: 45949
C1rl
Name: complement component 1, r subcomponent-like
Synonyms: C1r-LP, C1rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232371
Homologene: 9559
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Astn2
Name: astrotactin 2
Synonyms: Astnl, 1d8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56079
Homologene: 77850
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76376
Homologene: 10669
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, Pwwp2, D7Ertd517e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101631
Homologene: 19056
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: V2r16, VR16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22307
Homologene: 129606
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: beta3B, Naptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 669149
Homologene: 129606
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Parp2
Name: poly (ADP-ribose) polymerase family, member 2
Synonyms: Aspartl2, C78626, Adprt2, Adprtl2, PARP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11546
VEGA: 14
HGNC: HGNC:272
Homologene: 4004
Sp100
Name: nuclear antigen Sp100
Synonyms: A430075G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20684
Homologene: 86761
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Zfp422
Name: zinc finger protein 422
Synonyms: Krox-25-2, Krox26, Krox-26, KOX15, Krox25, 2900028O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67255
Homologene: 5067
Arhgef33
Name: Rho guanine nucleotide exchange factor (GEF) 33
Synonyms: LOC381112, Gm941
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381112
VEGA: 17
Homologene: 55190
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22404
Homologene: 7997
Hsdl2
Name: hydroxysteroid dehydrogenase like 2
Synonyms: 2610207I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72479
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384219
Homologene: 129606
Scai
Name: suppressor of cancer cell invasion
Synonyms: A930041I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320271
Homologene: 15523
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, uPARAP, Endo180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Ccdc130
Name: coiled-coil domain containing 130
Synonyms: 4930527D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67736
Homologene: 12183
Olfr1109
Name: olfactory receptor 1109
Synonyms: MOR172-5, GA_x6K02T2Q125-48586461-48585523
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258762
Homologene: 86672
Rgs7bp
Name: regulator of G-protein signalling 7 binding protein
Synonyms: A930030I01Rik, D13Bwg1146e, R7bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 52882
VEGA: 13
Homologene: 78705
Bcl2l14
Name: BCL2-like 14 (apoptosis facilitator)
Synonyms: 9030625M01Rik, 4933405K19Rik, 4930452K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66813
Homologene: 49840
Tmem28
Name: transmembrane protein 28
Synonyms: Fam155b, EG620592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 620592
Homologene: 83276
Msl3
Name: MSL complex subunit 3
Synonyms: Msl3l1, Msl31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17692
HGNC: HGNC:7370
Homologene: 40749
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 44,167,856 bp
  • A to G, chromosome 1 at 85,681,109 bp
  • A to T, chromosome 1 at 191,046,324 bp
  • A to G, chromosome 2 at 12,189,519 bp
  • G to A, chromosome 2 at 32,245,619 bp
  • A to T, chromosome 2 at 39,075,052 bp
  • T to A, chromosome 2 at 87,092,762 bp
  • A to G, chromosome 3 at 95,072,003 bp
  • T to C, chromosome 3 at 97,166,183 bp
  • T to C, chromosome 4 at 59,597,274 bp
  • G to A, chromosome 4 at 66,403,955 bp
  • T to C, chromosome 4 at 87,176,185 bp
  • T to C, chromosome 4 at 101,765,301 bp
  • T to C, chromosome 4 at 137,515,568 bp
  • C to A, chromosome 5 at 109,002,222 bp
  • C to T, chromosome 5 at 109,053,394 bp
  • C to T, chromosome 6 at 12,555,226 bp
  • T to C, chromosome 6 at 116,626,459 bp
  • T to A, chromosome 6 at 124,508,822 bp
  • A to G, chromosome 6 at 134,423,808 bp
  • C to T, chromosome 7 at 81,473,850 bp
  • T to C, chromosome 7 at 100,121,401 bp
  • G to A, chromosome 7 at 139,256,034 bp
  • G to A, chromosome 8 at 84,260,352 bp
  • TCCGCCGCCGCC to TCCGCCGCC, chromosome 10 at 70,189,170 bp
  • T to C, chromosome 11 at 6,342,601 bp
  • T to C, chromosome 11 at 9,354,856 bp
  • T to A, chromosome 11 at 52,119,262 bp
  • T to A, chromosome 11 at 93,921,353 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • C to A, chromosome 11 at 117,813,417 bp
  • T to C, chromosome 12 at 51,603,338 bp
  • A to C, chromosome 12 at 77,475,259 bp
  • T to C, chromosome 13 at 105,052,998 bp
  • G to A, chromosome 14 at 50,819,387 bp
  • A to G, chromosome 14 at 51,413,978 bp
  • T to C, chromosome 15 at 34,345,420 bp
  • A to G, chromosome 15 at 82,083,152 bp
  • A to T, chromosome 16 at 29,610,880 bp
  • A to G, chromosome 16 at 32,829,259 bp
  • G to A, chromosome 17 at 32,357,898 bp
  • A to G, chromosome 17 at 80,373,320 bp
  • A to T, chromosome 19 at 17,123,954 bp
  • G to A, chromosome X at 99,821,864 bp
  • C to T, chromosome X at 168,671,817 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3933 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040920-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.