Strain Name:
C57BL/6J-MtgxR3968Btlr/Mmmh
Stock Number:
040936-MU
Citation ID:
RRID:MMRRC_040936-MU
Other Names:
R3968 (G1), C57BL/6J-MtgxR3968Btlr
Major Collection:

Gene Information

Il21r
Name: interleukin 21 receptor
Synonyms: NILR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 60504
HGNC: HGNC:6006
Homologene: 11040
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20650
Homologene: 4911
Arhgef12
Name: Rho guanine nucleotide exchange factor (GEF) 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69632
VEGA: 9
Homologene: 9088
Pcm1
Name: pericentriolar material 1
Synonyms: 2600002H09Rik, C030044G17Rik, 9430077F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Fzd8
Name: frizzled class receptor 8
Synonyms: Fz8, mFZ8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14370
VEGA: 18
HGNC: HGNC:4046
Homologene: 40606
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: Net1 homolog, mNET1, 9530071N24Rik, 0610025H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56349
VEGA: 13
Homologene: 4283
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218503
VEGA: 13
Homologene: 9030
Yap1
Name: yes-associated protein 1
Synonyms: Yki, Yap, yorkie
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22601
Homologene: 4452
Ssb
Name: Sjogren syndrome antigen B
Synonyms: SS-B, La protein, autoantigen La
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20823
Homologene: 2366
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, Zak, B230120H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 65964
Homologene: 32331
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76501
Homologene: 8584
Tmc2
Name: transmembrane channel-like gene family 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 192140
Homologene: 25877
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Itgam
Name: integrin alpha M
Synonyms: CD11B (p170), Mac-1, Ly-40, complement component receptor 3 alpha, Mac-1 alpha, Mac-1a, Cd11b, CR3, CD11b/CD18, complement receptor type 3, F730045J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Fam38b, Piezo2, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 667742
Homologene: 49695
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: Liprin-alpha2, E130120L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Olfr921
Name: olfactory receptor 921
Synonyms: GA_x6K02T2PVTD-32478047-32478988, MOR165-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258778
VEGA: 9
Homologene: 128138
Cdhr2
Name: cadherin-related family member 2
Synonyms: Pcdh24, LOC268663
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 268663
Homologene: 134510
Ly75
Name: lymphocyte antigen 75
Synonyms: CD205, DEC-205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: reduced folate carrier, RFC1, RFC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 20509
Homologene: 57139
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 665227
Homologene: 129751
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67608
Homologene: 57048
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: EVER1, D11Ertd204e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217353
Homologene: 5258
H2-M2
Name: histocompatibility 2, M region locus 2
Synonyms: Thy19.4, H-2M2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14990
Homologene: 133732
Rab39
Name: RAB39, member RAS oncogene family
Synonyms: Rab39a, C230094F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270160
Homologene: 56773
Tnnc2
Name: troponin C2, fast
Synonyms: Tncs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21925
Homologene: 55727
Camk4
Name: calcium/calmodulin-dependent protein kinase IV
Synonyms: CaMKIV/Gr, D18Bwg0362e, Ca2+/calmodulin-dependent protein kinase type IV/Gr, A430110E23Rik, CaMKIV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 12326
VEGA: 18
HGNC: HGNC:1464
Homologene: 100780
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: flopsy, bv, nSR100, B230202K19Rik, 1500001A10Rik, fp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 68955
Homologene: 49869
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270151
VEGA: 9
Homologene: 11623
Ppl
Name: periplakin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Sema3g
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218877
Homologene: 10602
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: 2300001H05Rik, CYSLT2R, Cyslt2, CysLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70086
VEGA: 14
Homologene: 10688
Sval2
Name: seminal vesicle antigen-like 2
Synonyms: SLP-M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 84543
Homologene: 13055
Olfr722
Name: olfactory receptor 722
Synonyms: MOR241-3, GA_x6K02T2PMLR-5566715-5565789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258487
Homologene: 17270
Gm14401
Name: predicted gene 14401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100534275
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 111175
Homologene: 69255
Cela1
Name: chymotrypsin-like elastase family, member 1
Synonyms: PC-TsF, Ela1, 1810062B19Rik, Ela-1, 1810009A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 109901
VEGA: 15
HGNC: HGNC:3308
Homologene: 20454
Oard1
Name: O-acyl-ADP-ribose deacylase 1
Synonyms: AI314976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106821
VEGA: 17
Homologene: 17038
6430550D23Rik
Name: RIKEN cDNA 6430550D23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320095
Homologene: 122133
Gm5069
Name: predicted pseudogene 5069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 277333
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 72,276,309 bp
  • A to T, chromosome 1 at 180,327,798 bp
  • T to C, chromosome 2 at 60,327,873 bp
  • C to T, chromosome 2 at 69,867,449 bp
  • T to A, chromosome 2 at 72,438,193 bp
  • C to A, chromosome 2 at 101,897,141 bp
  • T to G, chromosome 2 at 130,202,071 bp
  • C to G, chromosome 2 at 154,564,022 bp
  • T to C, chromosome 2 at 155,974,205 bp
  • T to C, chromosome 2 at 164,777,537 bp
  • T to C, chromosome 2 at 177,086,996 bp
  • A to G, chromosome 5 at 116,444,744 bp
  • A to C, chromosome 6 at 40,644,957 bp
  • T to A, chromosome 6 at 41,861,927 bp
  • G to T, chromosome 7 at 125,628,043 bp
  • T to C, chromosome 7 at 128,113,033 bp
  • T to C, chromosome 8 at 41,325,830 bp
  • G to A, chromosome 8 at 70,770,421 bp
  • T to A, chromosome 8 at 106,997,140 bp
  • C to T, chromosome 9 at 7,973,876 bp
  • A to G, chromosome 9 at 38,775,368 bp
  • C to A, chromosome 9 at 43,005,551 bp
  • A to T, chromosome 9 at 44,255,425 bp
  • G to A, chromosome 9 at 53,686,632 bp
  • T to C, chromosome 10 at 77,041,846 bp
  • T to A, chromosome 10 at 106,906,521 bp
  • T to C, chromosome 11 at 117,769,292 bp
  • A to T, chromosome 11 at 121,238,421 bp
  • A to G, chromosome 13 at 3,907,795 bp
  • A to T, chromosome 13 at 54,726,458 bp
  • A to T, chromosome 13 at 98,735,056 bp
  • T to C, chromosome 14 at 31,226,521 bp
  • A to T, chromosome 14 at 49,895,526 bp
  • A to G, chromosome 14 at 73,030,174 bp
  • C to T, chromosome 15 at 100,684,653 bp
  • T to C, chromosome 16 at 5,100,332 bp
  • C to A, chromosome 17 at 18,258,385 bp
  • C to T, chromosome 17 at 37,481,306 bp
  • T to C, chromosome 17 at 48,415,254 bp
  • T to C, chromosome 18 at 9,214,070 bp
  • A to T, chromosome 18 at 12,580,341 bp
  • T to A, chromosome 18 at 33,179,581 bp
  • A to T, chromosome 18 at 63,011,696 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3968 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040936-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.