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Strain Name:
C57BL/6J-MtgxR4059Btlr/Mmmh
Stock Number:
040970-MU
Citation ID:
RRID:MMRRC_040970-MU
Other Names:
R4059 (G1), C57BL/6J-MtgxR4059Btlr
Major Collection:

Strain Information

Rgs8
Name: regulator of G-protein signaling 8
Synonyms: 6530413N01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67792
Homologene: 23152
Rnd3
Name: Rho family GTPase 3
Synonyms: 2610017M01Rik, Arhe, Rhoe
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74194
HGNC: HGNC:671
Homologene: 21074
Runx1
Name: runt related transcription factor 1
Synonyms: AML1, Pebp2a2, runt domain, alpha subunit 2, Cbfa2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12394
Homologene: 1331
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Dgat1
Name: diacylglycerol O-acyltransferase 1
Synonyms: D15Ertd23e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13350
HGNC: HGNC:2843
Homologene: 7688
Ptcd2
Name: pentatricopeptide repeat domain 2
Synonyms: 1190005P08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68927
VEGA: 13
Homologene: 11695
Aspscr1
Name: ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms: ASPCR1, RCC17, ASPC, 1190006K01Rik, TUG, ASPL
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68938
Homologene: 41550
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: A20-binding inhibitor of NF-kappa B activation, ABIN1, VAN, Nef
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70227
Homologene: 133818
Nfs1
Name: nitrogen fixation gene 1 (S. cerevisiae)
Synonyms: m-Nfs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18041
Homologene: 5463
Txnrd1
Name: thioredoxin reductase 1
Synonyms: TrxR1, TR1, TR alpha, TR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50493
VEGA: 10
Homologene: 55733
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76501
Homologene: 8584
Mettl13
Name: methyltransferase 13, eEF1A lysine and N-terminal methyltransferase
Synonyms: 5630401D24Rik, Eef1aknmt
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71449
Homologene: 32285
Atp13a3
Name: ATPase type 13A3
Synonyms: LOC224088, LOC224087, LOC385637
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224088
Homologene: 23455
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213783
Homologene: 18897
Cd81
Name: CD81 antigen
Synonyms: Tspan28, Tapa1, Tapa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12520
HGNC: HGNC:1701
Homologene: 20915
Fam13c
Name: family with sequence similarity 13, member C
Synonyms: C030038O19Rik, 1200015N20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71721
Homologene: 11490
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234076
Homologene: 32376
Ucp3
Name: uncoupling protein 3 (mitochondrial, proton carrier)
Synonyms: UCP-3, Slc25a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22229
Homologene: 2517
Lmo2
Name: LIM domain only 2
Synonyms: Rbtn-2, Rbtn2, Rhom-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16909
HGNC: HGNC:6642
Homologene: 4072
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: Ehm2, D4Ertd346e, 6430543G08Rik, Lulu2, Epb4.1l4b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54357
Homologene: 69270
Rhoh
Name: ras homolog family member H
Synonyms: 5830400A04Rik, Arhh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74734
HGNC: HGNC:686
Homologene: 3180
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Dennd4a
Name: DENN domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Sec14l1
Name: SEC14-like lipid binding 1
Synonyms: 1200017E04Rik, 2810012L19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74136
Homologene: 37719
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: beta4GalT-III, ESTM26, 9530061M23Rik, R74981
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, 6530406M24Rik, 4930431N21Rik, Ccp3, Ccp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Klhl32
Name: kelch-like 32
Synonyms: LOC384000, D4Ertd389e, 6430524H05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212390
Homologene: 14173
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217310
Homologene: 12737
Tmpo
Name: thymopoietin
Synonyms: TP, 5630400D24Rik, LAP2, lamina-associated polypeptide 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21917
VEGA: 10
Homologene: 31144
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171405
Homologene: 77136
Rhbdl3
Name: rhomboid like 3
Synonyms: Ventrhoid, Vrho, Rhbdl4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246104
Homologene: 34700
Cfap45
Name: cilia and flagella associated protein 45
Synonyms: 1700028D05Rik, Nesg1, Ccdc19
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71870
Homologene: 71837
Or4c104
Name: olfactory receptor family 4 subfamily C member 104
Synonyms: GA_x6K02T2Q125-50231574-50230642, MOR230-8, Olfr1199
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258450
Homologene: 128092
Krt23
Name: keratin 23
Synonyms: K23, CK23, Krt1-23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94179
HGNC: HGNC:6438
Homologene: 9172
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Gm6821
Name: predicted gene 6821
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 101055651
Zfp715
Name: zinc finger protein 715
Synonyms: 2610041B18Rik, mszf15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69930
Homologene: 74591
Fjx1
Name: four jointed box 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14221
Homologene: 7717
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: 4831416G18Rik, Sh3md4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Spire1
Name: spire type actin nucleation factor 1
Synonyms: Spir-1, 6030430B19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68166
VEGA: 18
Homologene: 35507
BC051019
Name: cDNA sequence BC051019
Synonyms: D7H11orf16, ICRFP703N2430Q5.5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57355
HGNC: HGNC:1169
Homologene: 49631
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101502
Homologene: 41617
4930453N24Rik
Name: RIKEN cDNA 4930453N24 gene
Synonyms: din
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67609
Homologene: 27867
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50524
Homologene: 9269
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Capza1
Name: capping actin protein of muscle Z-line subunit alpha 1
Synonyms: Cappa1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12340
HGNC: HGNC:1488
Homologene: 24376
Tspan8
Name: tetraspanin 8
Synonyms: E330007O21Rik, Tm4sf3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216350
VEGA: 10
Homologene: 20968
Runx1t1
Name: RUNX1 translocation partner 1
Synonyms: ETO, MTG8, Cbfa2t1h
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12395
HGNC: HGNC:1535
Homologene: 3801
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 87,486,231 bp
  • A to G, chromosome 1 at 135,969,756 bp
  • A to G, chromosome 1 at 153,690,996 bp
  • G to T, chromosome 1 at 162,546,186 bp
  • C to A, chromosome 1 at 171,274,043 bp
  • G to T, chromosome 1 at 172,538,489 bp
  • A to G, chromosome 2 at 51,148,748 bp
  • C to T, chromosome 2 at 88,756,451 bp
  • T to C, chromosome 2 at 101,895,154 bp
  • T to C, chromosome 2 at 102,450,721 bp
  • T to C, chromosome 2 at 103,981,062 bp
  • T to C, chromosome 2 at 156,139,716 bp
  • A to G, chromosome 3 at 87,781,479 bp
  • A to G, chromosome 3 at 88,381,008 bp
  • T to C, chromosome 3 at 104,825,111 bp
  • T to C, chromosome 4 at 13,889,769 bp
  • T to C, chromosome 4 at 24,792,781 bp
  • C to T, chromosome 4 at 57,024,337 bp
  • G to A, chromosome 5 at 65,892,588 bp
  • T to C, chromosome 5 at 137,436,820 bp
  • T to G, chromosome 6 at 4,756,427 bp
  • T to C, chromosome 6 at 34,846,899 bp
  • A to C, chromosome 7 at 39,535,399 bp
  • T to C, chromosome 7 at 43,301,731 bp
  • T to C, chromosome 7 at 100,482,664 bp
  • C to T, chromosome 7 at 109,717,995 bp
  • T to C, chromosome 7 at 127,801,545 bp
  • G to T, chromosome 7 at 143,065,293 bp
  • A to G, chromosome 8 at 13,320,848 bp
  • A to G, chromosome 8 at 105,427,796 bp
  • A to G, chromosome 9 at 64,911,892 bp
  • A to G, chromosome 10 at 3,957,087 bp
  • T to C, chromosome 10 at 59,083,533 bp
  • A to G, chromosome 10 at 62,956,989 bp
  • T to C, chromosome 10 at 70,554,508 bp
  • A to G, chromosome 10 at 82,885,280 bp
  • A to G, chromosome 10 at 91,162,261 bp
  • C to T, chromosome 10 at 115,835,282 bp
  • A to G, chromosome 11 at 54,911,569 bp
  • A to G, chromosome 11 at 73,112,134 bp
  • C to T, chromosome 11 at 80,346,815 bp
  • T to C, chromosome 11 at 99,485,788 bp
  • C to T, chromosome 11 at 115,356,739 bp
  • T to A, chromosome 11 at 117,149,198 bp
  • T to C, chromosome 11 at 120,686,679 bp
  • T to C, chromosome 13 at 19,141,998 bp
  • A to G, chromosome 13 at 99,344,576 bp
  • A to G, chromosome 14 at 52,314,571 bp
  • C to T, chromosome 15 at 44,550,760 bp
  • G to T, chromosome 15 at 76,504,171 bp
  • C to A, chromosome 16 at 30,354,246 bp
  • A to G, chromosome 16 at 64,766,458 bp
  • A to G, chromosome 16 at 92,644,246 bp
  • A to G, chromosome 17 at 18,598,077 bp
  • G to A, chromosome 18 at 24,679,390 bp
  • A to G, chromosome 18 at 67,545,713 bp
  • T to A, chromosome 19 at 7,879,608 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4059 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040970-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.