Strain Name:
C57BL/6J-MtgxR4075Btlr/Mmmh
Stock Number:
040974-MU
Citation ID:
RRID:MMRRC_040974-MU
Other Names:
R4075 (G1), C57BL/6J-MtgxR4075Btlr
Major Collection:

Gene Information

Egf
Name: epidermal growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Slc21a7, Oatp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Dst
Name: dystonin
Synonyms: Macf2, Bpag, athetoid, bullous pemphigoid antigen 1, nmf339, 2310001O04Rik, nmf203, A830042E19Rik, ah, Bpag1, BPAG1, BPAG1-n, bullous pemphigoid antigen 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: 9430080K19Rik, Nik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Rev1
Name: REV1, DNA directed polymerase
Synonyms: Rev1l, REV1, 1110027I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56210
Homologene: 32309
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: MCPH5, Calmbp1, Sha1, Aspm, D330028K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Synonyms: PTP-1B, PTP1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19246
HGNC: HGNC:9642
Homologene: 2119
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, 6330407G04Rik, CHMP family, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Il17rc
Name: interleukin 17 receptor C
Synonyms: IL17-RL, 1110025H02Rik, Il17rl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171095
Homologene: 15894
Arhgef2
Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Synonyms: Lfc, P40, Lbcl1, GEF-H1, GEFH1, LFP40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms: methionine synthase, MS, D830038K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238505
VEGA: 13
HGNC: HGNC:7468
Homologene: 37280
Tab3
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 3
Synonyms: 4921526G09Rik, Map3k7ip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 66724
Homologene: 17673
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: 9230110G02Rik, ZNF-U69274
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 271377
Homologene: 8678
Agtr1a
Name: angiotensin II receptor, type 1a
Synonyms: Agtr1a, 1810074K20Rik, Agtr-1a, AT1, AT1a, Agt1ar, Angtr-1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11607
HGNC: HGNC:336
Homologene: 3556
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Hormad1
Name: HORMA domain containing 1
Synonyms: Nohma, 4921522K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67981
Homologene: 69415
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1134Clo, Mdnah5, b2b1565Clo, b2b1537Clo, b2b1154Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Ikzf3
Name: IKAROS family zinc finger 3
Synonyms: Aiolos, 5830411O07Rik, Zfpn1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22780
Homologene: 8269
Olfr670
Name: olfactory receptor 670
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381417
Pld5
Name: phospholipase D family, member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319455
Homologene: 16081
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: equatorin, Afaf, 1700028B15Rik, 4930579C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Tm2d3
Name: TM2 domain containing 3
Synonyms: 1110025I09Rik, 5930422O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68634
Homologene: 12275
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246791
Homologene: 44937
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Tyro7, Ufo, Ark
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Nxt1
Name: NTF2-related export protein 1
Synonyms: 1110001N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56488
Homologene: 8301
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213234
Homologene: 11661
Ifi44
Name: interferon-induced protein 44
Synonyms: A430056A10Rik, p44, MTAP44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99899
Homologene: 4683
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: TSC403, DC-LAMP, Cd208, 1200002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmgox, Hmg1-rs1, T160, Hmgi-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Pidd1
Name: p53 induced death domain protein 1
Synonyms: Lrdd, 1200011D09Rik, Pidd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57913
Homologene: 11220
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76179
Homologene: 44504
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Rnh2, Nalp-alpha, Nalp4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83564
Homologene: 75315
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Ttc4
Name: tetratricopeptide repeat domain 4
Synonyms: 2810002P21Rik, L62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72354
Homologene: 31249
Olfr1350
Name: olfactory receptor 1350
Synonyms: MOR222-3, GA_x6K02T2QGBW-3300391-3301317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258384
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210503
Homologene: 138402
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243833
Homologene: 10889
Acsm4
Name: acyl-CoA synthetase medium-chain family member 4
Synonyms: O-MACS, OMACS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233801
Homologene: 72281
Svs2
Name: seminal vesicle secretory protein 2
Synonyms: SVS II, semenoclotin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53878
Homologene: 49325
Las1l
Name: LAS1-like (S. cerevisiae)
Synonyms: 1810030A06Rik, 5830482G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 76130
Homologene: 32746
Depp1
Name: DEPP1 autophagy regulator
Synonyms: Depp, 8430408G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213393
Homologene: 48491
Lce1l
Name: late cornified envelope 1L
Synonyms: 1110008K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73730
Gm28379
Name: predicted gene 28379
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm15063
Name: predicted gene 15063
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,192,269 bp
  • T to G, chromosome 1 at 38,054,238 bp
  • T to C, chromosome 1 at 40,023,462 bp
  • T to C, chromosome 1 at 139,474,285 bp
  • G to T, chromosome 1 at 176,044,868 bp
  • A to G, chromosome 2 at 13,313,999 bp
  • C to T, chromosome 2 at 82,982,901 bp
  • A to C, chromosome 2 at 85,045,568 bp
  • T to G, chromosome 2 at 122,514,411 bp
  • A to G, chromosome 2 at 148,675,732 bp
  • T to C, chromosome 2 at 164,237,318 bp
  • T to A, chromosome 2 at 167,976,513 bp
  • C to T, chromosome 3 at 75,105,671 bp
  • T to C, chromosome 3 at 88,646,296 bp
  • C to T, chromosome 3 at 92,850,233 bp
  • T to C, chromosome 3 at 95,578,203 bp
  • C to T, chromosome 3 at 129,735,969 bp
  • A to T, chromosome 3 at 151,745,976 bp
  • A to G, chromosome 4 at 94,919,962 bp
  • T to C, chromosome 4 at 106,670,485 bp
  • A to G, chromosome 5 at 57,721,808 bp
  • A to G, chromosome 6 at 113,481,197 bp
  • A to G, chromosome 6 at 116,652,068 bp
  • A to T, chromosome 6 at 123,787,415 bp
  • A to T, chromosome 6 at 142,268,224 bp
  • A to G, chromosome 7 at 6,072,710 bp
  • T to C, chromosome 7 at 6,570,143 bp
  • A to G, chromosome 7 at 12,891,221 bp
  • G to T, chromosome 7 at 15,625,799 bp
  • A to G, chromosome 7 at 25,763,911 bp
  • T to A, chromosome 7 at 65,697,750 bp
  • A to T, chromosome 7 at 104,960,716 bp
  • T to A, chromosome 7 at 119,698,758 bp
  • A to G, chromosome 7 at 121,667,782 bp
  • A to G, chromosome 7 at 141,440,826 bp
  • A to T, chromosome 8 at 43,626,350 bp
  • A to G, chromosome 9 at 66,418,492 bp
  • A to G, chromosome 9 at 114,622,947 bp
  • C to T, chromosome 10 at 126,013,408 bp
  • G to T, chromosome 11 at 98,467,643 bp
  • C to A, chromosome 13 at 12,215,412 bp
  • A to G, chromosome 13 at 30,381,834 bp
  • A to T, chromosome 14 at 69,732,281 bp
  • T to A, chromosome 15 at 28,293,791 bp
  • G to A, chromosome 16 at 13,130,685 bp
  • A to G, chromosome 16 at 19,700,716 bp
  • C to T, chromosome 16 at 55,998,064 bp
  • T to C, chromosome 17 at 21,398,159 bp
  • T to G, chromosome 17 at 43,450,195 bp
  • T to G, chromosome 18 at 20,340,070 bp
  • T to C, chromosome X at 75,575,052 bp
  • G to T, chromosome X at 85,614,457 bp
  • T to C, chromosome X at 95,950,381 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4075 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040974-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.