Strain Name:
C57BL/6J-MtgxR4090Btlr/Mmmh
Stock Number:
040983-MU
Citation ID:
RRID:MMRRC_040983-MU
Other Names:
R4090 (G1), C57BL/6J-MtgxR4090Btlr
Major Collection:

Gene Information

Cd36
Name: CD36 molecule
Synonyms: Scarb3, FAT, fatty acid translocase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 245945
Homologene: 36932
Topors
Name: topoisomerase I binding, arginine/serine-rich
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 106021
Homologene: 4237
Ddx4
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Synonyms: VASA, Mvh, mvh / m'vasa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 13206
VEGA: 13
Homologene: 49227
Exoc6
Name: exocyst complex component 6
Synonyms: Sec15l1, Sec15, msec15, 4833405E05Rik, hbd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107371
VEGA: 19
Homologene: 41305
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Wdr26
Name: WD repeat domain 26
Synonyms: Gid7, 1600024A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226757
Homologene: 11857
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226442
Homologene: 8270
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Gja8
Name: gap junction protein, alpha 8
Synonyms: Lop10, connexin 50, Cx50, Cnx50, Aey5, alpha 8 connexin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14616
HGNC: HGNC:4281
Homologene: 3857
Htr1f
Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: Htr1eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 15557
VEGA: 16
HGNC: HGNC:5292
Homologene: 37361
Hjurp
Name: Holliday junction recognition protein
Synonyms: A730008H23Rik, C330011F01Rik, 6430706D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381280
Homologene: 10184
Hsd17b13
Name: hydroxysteroid (17-beta) dehydrogenase 13
Synonyms: Pan1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243168
Homologene: 71549
Arhgef2
Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Synonyms: GEF-H1, P40, Lfc, Lbcl1, GEFH1, LFP40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 272347
Homologene: 12358
Ppme1
Name: protein phosphatase methylesterase 1
Synonyms: PME-1, 2700017M01Rik, 1110069N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72590
Homologene: 6099
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434179
Homologene: 134004
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: E130010M05Rik, [a]4(IV)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Igkc
Name: immunoglobulin kappa constant
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16071
Slurp1
Name: secreted Ly6/Plaur domain containing 1
Synonyms: 1110021N19Rik, ARS component B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 57277
Homologene: 10710
Mlxipl
Name: MLX interacting protein-like
Synonyms: bHLHd14, WS-bHLH, Wbscr14, ChREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 58805
Homologene: 32507
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, b2b012Clo, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73692
Homologene: 11315
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 380660
Homologene: 11587
Olfr389
Name: olfactory receptor 389
Synonyms: MOR135-6, GA_x6K02T2P1NL-3932085-3931147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 259011
Homologene: 85925
Ksr1
Name: kinase suppressor of ras 1
Synonyms: D11Bhm183e, B-KSR1, D11Bhm184e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215243
Homologene: 11885
Olfr829
Name: olfactory receptor 829
Synonyms: MOR147-1, GA_x6K02T2PVTD-12599710-12600648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 259070
Homologene: 138324
Sypl2
Name: synaptophysin-like 2
Synonyms: Mg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17306
Homologene: 7421
Olfr1328
Name: olfactory receptor 1328
Synonyms: GA_x6K02T2QD9B-18602750-18603691, MOR259-1, MOR259-13, MOR259-1, Olfr1519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 258394
Homologene: 121524
Fam83f
Name: family with sequence similarity 83, member F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 213956
VEGA: 15
Homologene: 16313
Gm12789
Name: predicted gene 12789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381536
Apc2
Name: adenomatosis polyposis coli 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 23805
Homologene: 4299
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171200
Homologene: 134034
Cep250
Name: centrosomal protein 250
Synonyms: B230210E21Rik, Cep2, Inmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Tmem171
Name: transmembrane protein 171
Synonyms: LOC380863
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 380863
Homologene: 18301
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241066
Homologene: 11689
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 627569
Homologene: 129606
Rragd
Name: Ras-related GTP binding D
Synonyms: C030003H22Rik, D4Ertd174e, 5730543C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 52187
Homologene: 49667
Tubg1
Name: tubulin, gamma 1
Synonyms: 1500010O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103733
Homologene: 833
Taar8a
Name: trace amine-associated receptor 8A
Synonyms: LOC215859
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215859
Homologene: 77586
Vmn1r188
Name: vomeronasal 1 receptor 188
Synonyms: V1rh17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 252912
Homologene: 110880
Snap23
Name: synaptosomal-associated protein 23
Synonyms: Sndt, Syndet, SNAP-23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20619
Homologene: 37857
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 68888
Homologene: 87422
Olfr220
Name: olfactory receptor 220
Synonyms: GA_x6K02SYWY4V-595-239, GA_x6K02T2P20D-20731742-20730694, Olfr413-ps1, MOR103-17, MOR103-13P, EG546747
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 546747
Homologene: 67062
Cldn34c4
Name: claudin 34C4
Synonyms: 4930412D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 73934
Homologene: 132184
Gm1988
Name: predicted gene 1988
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100038967
Homologene: 80005
Gm21370
Name: predicted gene, 21370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 100861977
VEGA: 13
Gm15956
Name: predicted gene 15956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,136,347 bp
  • T to A, chromosome 1 at 82,523,922 bp
  • G to C, chromosome 1 at 88,277,215 bp
  • T to A, chromosome 1 at 136,626,121 bp
  • A to G, chromosome 1 at 174,448,934 bp
  • T to C, chromosome 1 at 181,203,114 bp
  • A to G, chromosome 1 at 193,181,320 bp
  • A to G, chromosome 2 at 120,585,580 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • G to C, chromosome 3 at 88,643,878 bp
  • A to G, chromosome 3 at 96,919,152 bp
  • A to G, chromosome 3 at 108,217,676 bp
  • C to T, chromosome 4 at 33,007,155 bp
  • T to C, chromosome 4 at 40,260,794 bp
  • A to T, chromosome 4 at 101,988,329 bp
  • C to T, chromosome 4 at 118,934,033 bp
  • A to G, chromosome 5 at 17,785,720 bp
  • A to G, chromosome 5 at 66,022,737 bp
  • T to A, chromosome 5 at 103,965,854 bp
  • T to A, chromosome 5 at 109,091,546 bp
  • G to A, chromosome 5 at 120,675,609 bp
  • A to T, chromosome 5 at 135,132,527 bp
  • T to A, chromosome 6 at 47,866,225 bp
  • T to A, chromosome 6 at 57,404,735 bp
  • T to C, chromosome 6 at 70,726,458 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • A to G, chromosome 7 at 39,170,868 bp
  • A to G, chromosome 7 at 42,662,874 bp
  • A to T, chromosome 7 at 100,347,837 bp
  • T to C, chromosome 9 at 18,857,102 bp
  • T to A, chromosome 10 at 24,077,164 bp
  • A to G, chromosome 10 at 80,305,544 bp
  • T to G, chromosome 10 at 107,053,452 bp
  • A to G, chromosome 11 at 73,776,841 bp
  • T to C, chromosome 11 at 79,027,477 bp
  • T to A, chromosome 11 at 101,124,538 bp
  • T to C, chromosome 11 at 107,081,523 bp
  • T to C, chromosome 13 at 22,088,602 bp
  • A to T, chromosome 13 at 98,692,588 bp
  • A to G, chromosome 13 at 112,613,761 bp
  • A to G, chromosome 13 at 120,026,953 bp
  • T to A, chromosome 15 at 8,212,358 bp
  • T to C, chromosome 15 at 74,726,875 bp
  • A to T, chromosome 15 at 80,692,192 bp
  • T to C, chromosome 16 at 64,925,961 bp
  • T to C, chromosome 18 at 12,198,162 bp
  • A to G, chromosome 18 at 36,948,451 bp
  • A to G, chromosome 19 at 37,571,912 bp
  • A to T, chromosome X at 127,721,388 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4090 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040983-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.