Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR4120Btlr/Mmmh
Stock Number:
040993-MU
Citation ID:
RRID:MMRRC_040993-MU
Other Names:
R4120 (G1), C57BL/6J-MtgxR4120Btlr
Major Collection:

Strain Information

St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: ST3Gal V, mST3Gal V, GM3-specific sialytransferase, GM3 synthase, [a]2, 3S-T, Siat9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Fip1l1
Name: factor interacting with PAPOLA and CPSF1
Synonyms: Rje, 1300019H17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66899
Homologene: 136254
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Clca2
Name: chloride channel accessory 2
Synonyms: Clca5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229933
HGNC: HGNC:2016
Homologene: 4765
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Sec13
Name: SEC13 homolog, nuclear pore and COPII coat complex component
Synonyms: 1110003H02Rik, Sec13r, Sec13l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110379
Homologene: 6479
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Dennd2a
Name: DENN domain containing 2A
Synonyms: B930096L08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209773
Homologene: 35238
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Gfra2
Name: glial cell line derived neurotrophic factor family receptor alpha 2
Synonyms: GFR alpha 2, GFR alpha-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14586
VEGA: 14
HGNC: HGNC:4244
Homologene: 1145
Pink1
Name: PTEN induced putative kinase 1
Synonyms: 1190006F07Rik, brpk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68943
Homologene: 32672
Oca2
Name: oculocutaneous albinism II
Synonyms: D7H15S12, D7H15S12, p
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18431
HGNC: HGNC:8101
Homologene: 37281
Stradb
Name: STE20-related kinase adaptor beta
Synonyms: PRO1038, D1Ucla2, Als2cr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227154
Homologene: 10237
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Afap1l1
Name: actin filament associated protein 1-like 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106877
Homologene: 18728
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: Mem2, 2810409M01Rik, ZFYVE7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17281
Homologene: 11561
Ptchd3
Name: patched domain containing 3
Synonyms: 4933440L20Rik, 4930451E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74675
Homologene: 111041
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640524
Homologene: 41150
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Zkscan3
Name: zinc finger with KRAB and SCAN domains 3
Synonyms: 2810435N07Rik, Skz1, Zfp307, Zfp306
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72739
Homologene: 130732
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Etv3
Name: ets variant 3
Synonyms: ETS-domain transcriptional repressor, METS, Pe1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27049
HGNC: HGNC:3492
Homologene: 21085
Sp140l2
Name: Sp140 nuclear body protein like 2
Synonyms: OTTMUSG00000029174, C130026I21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620078
Homologene: 131208
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Col4a-1, Del(8)Bru44H, Del(8)44H, Bru, Svc, Raw, alpha1(IV) collagen
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, argonaute 4, Eif2c4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76850
Homologene: 41184
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: HD, MFP, L-bifunctional enzyme, L-PBE, 1300002P22Rik, MFP1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545481
Homologene: 53500
Or51v8
Name: olfactory receptor family 51 subfamily V member 8
Synonyms: GA_x6K02T2PBJ9-6394126-6393197, MOR4-2P, Olfr624
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258189
Homologene: 66460
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: 1500005N04Rik, Ihpk2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76500
Homologene: 56929
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: 2810020C19Rik, 1110034A24Rik, Ktu, kintoun
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109065
Homologene: 10026
Zfp936
Name: zinc finger protein 936
Synonyms: EG435970, Gm9272, I1C0022H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Hspa2
Name: heat shock protein 2
Synonyms: 70kDa, Hsp70-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Fastkd1
Name: FAST kinase domains 1
Synonyms: 5330408N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320720
Homologene: 36420
Ripor1
Name: RHO family interacting cell polarization regulator 1
Synonyms: 2310066E14Rik, Fam65a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75687
Homologene: 11564
Mas1
Name: MAS1 oncogene
Synonyms: Mas-1, Mas receptor, MasR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17171
HGNC: HGNC:6899
Homologene: 1782
Or8b9
Name: olfactory receptor family 8 subfamily B member 9
Synonyms: GA_x6K02T2PVTD-31540342-31541277, MOR161-5, Olfr877
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258412
Homologene: 121556
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: PSD93, Chapsyn-110, B330007M19Rik, A330103J02Rik, LOC382816, Dlgh2, B230218P12Rik, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Vmn2r39
Name: vomeronasal 2, receptor 39
Synonyms: EG545909
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545909
Homologene: 113703
Dppa5a
Name: developmental pluripotency associated 5A
Synonyms: Esg1, ecat2, Dppa5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434423
Homologene: 104905
Flvcr2
Name: feline leukemia virus subgroup C cellular receptor 2
Synonyms: CCT, Mfsd7c
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217721
VEGA: 12
Homologene: 9840
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: Nalp1c, OTTMUSG00000006090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Asnsd1
Name: asparagine synthetase domain containing 1
Synonyms: 2210409M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70396
Homologene: 6564
Otub2
Name: OTU domain, ubiquitin aldehyde binding 2
Synonyms: 2010015L18Rik, OTU2, OTB2, 4930586I02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68149
Homologene: 57056
Vmn2r129
Name: vomeronasal 2, receptor 129
Synonyms: V2r8, V2r9, Vmn2r-ps160, Vmn2r-ps159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22314
Gm6003
Name: predicted gene 6003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102637838
Homologene: 141213
Gm9951
Name: predicted gene 9951
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 25,094,307 bp
  • A to G, chromosome 1 at 53,347,995 bp
  • T to A, chromosome 1 at 58,980,009 bp
  • G to A, chromosome 1 at 66,415,904 bp
  • C to T, chromosome 1 at 85,259,821 bp
  • T to C, chromosome 1 at 194,780,627 bp
  • T to A, chromosome 2 at 69,707,310 bp
  • T to A, chromosome 2 at 119,757,948 bp
  • T to A, chromosome 2 at 120,064,529 bp
  • A to G, chromosome 2 at 158,532,330 bp
  • C to A, chromosome 2 at 161,021,068 bp
  • A to G, chromosome 3 at 87,536,282 bp
  • T to C, chromosome 3 at 144,810,852 bp
  • A to G, chromosome 4 at 126,496,807 bp
  • G to A, chromosome 4 at 138,315,511 bp
  • G to T, chromosome 4 at 156,334,483 bp
  • T to A, chromosome 5 at 74,588,191 bp
  • G to A, chromosome 6 at 39,465,096 bp
  • A to G, chromosome 6 at 72,142,439 bp
  • A to T, chromosome 6 at 90,662,602 bp
  • T to C, chromosome 6 at 113,734,676 bp
  • G to A, chromosome 7 at 9,023,674 bp
  • T to A, chromosome 7 at 33,165,551 bp
  • A to G, chromosome 7 at 43,190,206 bp
  • A to T, chromosome 7 at 56,254,882 bp
  • G to A, chromosome 7 at 91,965,638 bp
  • T to C, chromosome 7 at 103,671,014 bp
  • G to A, chromosome 8 at 11,206,263 bp
  • T to C, chromosome 8 at 34,055,839 bp
  • T to A, chromosome 8 at 105,618,857 bp
  • T to C, chromosome 8 at 122,863,423 bp
  • T to C, chromosome 9 at 37,855,409 bp
  • A to T, chromosome 9 at 78,367,855 bp
  • G to A, chromosome 9 at 108,805,648 bp
  • T to C, chromosome 9 at 123,825,626 bp
  • T to A, chromosome 10 at 5,409,798 bp
  • A to G, chromosome 10 at 18,130,718 bp
  • A to G, chromosome 10 at 109,903,744 bp
  • T to C, chromosome 11 at 71,242,533 bp
  • G to A, chromosome 11 at 72,714,484 bp
  • T to C, chromosome 11 at 115,873,492 bp
  • T to A, chromosome 11 at 121,830,746 bp
  • C to T, chromosome 12 at 55,640,644 bp
  • T to C, chromosome 12 at 69,198,038 bp
  • A to G, chromosome 12 at 76,405,234 bp
  • T to C, chromosome 12 at 85,786,129 bp
  • T to C, chromosome 12 at 103,404,230 bp
  • T to C, chromosome 13 at 21,393,949 bp
  • A to T, chromosome 14 at 51,573,077 bp
  • A to G, chromosome 14 at 70,966,275 bp
  • A to C, chromosome 15 at 10,539,920 bp
  • A to G, chromosome 16 at 21,763,184 bp
  • A to T, chromosome 17 at 12,842,346 bp
  • T to C, chromosome 17 at 19,531,953 bp
  • A to G, chromosome 18 at 57,899,355 bp
  • T to C, chromosome 18 at 61,739,172 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4120 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040993-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.