Strain Name:
C57BL/6J-MtgxR4163Btlr/Mmmh
Stock Number:
041006-MU
Citation ID:
RRID:MMRRC_041006-MU
Other Names:
R4163 (G1), C57BL/6J-MtgxR4163Btlr
Major Collection:

Gene Information

Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72895
Homologene: 12485
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: Tkrb, trkB, C030027L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, b2b3190Clo, Dock180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Prep
Name: prolyl endopeptidase
Synonyms: Pop, D10Wsu136e, prolyl oligopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19072
VEGA: 10
HGNC: HGNC:9358
Homologene: 2042
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, D630005A10Rik, A430032G04Rik, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 8030493P09Rik, 4930429A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 360013
Homologene: 7977
Dcaf8
Name: DDB1 and CUL4 associated factor 8
Synonyms: D1Dau35e, Wdr42a, H326, D1Ucla4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98193
Homologene: 56725
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Cnot9
Name: CCR4-NOT transcription complex, subunit 9
Synonyms: Rqcd1, 2610007F23Rik, FL10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 58184
Homologene: 3973
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Pcdh20
Name: protocadherin 20
Synonyms: PCDH13, C630015B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219257
Homologene: 11277
Gm128
Name: predicted gene 128
Synonyms: Ment, Pmis1, LOC229588
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229588
Homologene: 9885
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: 1200013F24Rik, SRrp53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66880
Homologene: 41147
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: TA1, D0H16S474E, LAT1, Gm42049
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20539
Homologene: 55759
Kcna4
Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Synonyms: Kv1.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16492
HGNC: HGNC:6222
Homologene: 20514
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: Rme8, LOC382100, D030002L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235567
Homologene: 13574
Mis12
Name: MIS12 kinetochore complex component
Synonyms: 2510025F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67139
Homologene: 11429
Chst10
Name: carbohydrate sulfotransferase 10
Synonyms: Hnk-1st, ST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98388
Homologene: 21013
Adgrf4
Name: adhesion G protein-coupled receptor F4
Synonyms: 4632435A09Rik, Gpr115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78249
Homologene: 51953
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Bpifa3
Name: BPI fold containing family A, member 3
Synonyms: 1700058C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73388
Homologene: 52268
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242259
Homologene: 72094
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224079
Homologene: 75330
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69922
Homologene: 55966
Hexdc
Name: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238023
Homologene: 68120
Olfr699
Name: olfactory receptor 699
Synonyms: GA_x6K02T2PBJ9-9168355-9167405, MOR283-10P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258180
Homologene: 79391
Fam189a2
Name: family with sequence similarity 189, member A2
Synonyms: LOC381217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 58234
Homologene: 75163
Frk
Name: fyn-related kinase
Synonyms: BSK/IYK, GTK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14302
VEGA: 10
HGNC: HGNC:3955
Homologene: 48065
Shox2
Name: short stature homeobox 2
Synonyms: Prx3, 6330543G17Rik, Og12x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20429
Homologene: 68535
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231642
Homologene: 18393
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CD11C (p150) alpha polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Slfn3
Name: schlafen 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20557
Homologene: 133236
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: Cox-3, cyclooxygenase 1, COX1, Cox-1, Pghs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Spout1
Name: SPOUT domain containing methyltransferase 1
Synonyms: D2Wsu81e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227695
Homologene: 6704
Olfr58
Name: olfactory receptor 58
Synonyms: MOR146-7P, GA_x6K02T2PVTD-13523015-13523944, MOR146-3, IG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18358
Homologene: 134093
4930555F03Rik
Name: RIKEN cDNA 4930555F03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75359
Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
Synonyms: Fc gamma RIIB, CD32, Ly-m20, Fcgr2, Fcr-3, LyM-1, Fcgr2a, F630109E10Rik, FcgammaRIIB, FcgRII, Fc[g]RII, Ly-17, Fcr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14130
HGNC: HGNC:3618
Homologene: 2974
Olfr488
Name: olfactory receptor 488
Synonyms: MOR204-15, GA_x6K02T2PBJ9-10586187-10585243
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258727
Homologene: 110483
Trim72
Name: tripartite motif-containing 72
Synonyms: mitsugumin 53, MG53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434246
Homologene: 66924
Elovl7
Name: ELOVL family member 7, elongation of long chain fatty acids (yeast)
Synonyms: 9130013K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74559
VEGA: 13
Homologene: 23672
Cops5
Name: COP9 signalosome subunit 5
Synonyms: Sgn5, JUN activation binding protein, COP9 complex S5, Jab1, CSN5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26754
HGNC: HGNC:2240
Homologene: 55992
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68888
Homologene: 87422
4930404N11Rik
Name: RIKEN cDNA 4930404N11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432479
Homologene: 47801
Mir6244
Name: microRNA 6244
Synonyms: mmu-mir-6244
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102465150
VEGA: 9
Bnip5
Name: BCL2 interacting protein 5
Synonyms: 4930539E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 207819
Homologene: 52098
Gm2223
Name: predicted pseudogene 2223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 100039419
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,030,687 bp
  • T to A, chromosome 1 at 38,871,823 bp
  • C to T, chromosome 1 at 74,528,847 bp
  • A to G, chromosome 1 at 86,821,237 bp
  • T to C, chromosome 1 at 170,963,447 bp
  • T to G, chromosome 1 at 172,192,570 bp
  • C to T, chromosome 2 at 30,177,577 bp
  • C to T, chromosome 2 at 36,251,334 bp
  • G to C, chromosome 2 at 107,295,806 bp
  • T to C, chromosome 2 at 117,282,654 bp
  • A to G, chromosome 2 at 154,135,596 bp
  • A to G, chromosome 2 at 174,644,029 bp
  • T to C, chromosome 3 at 66,973,771 bp
  • T to A, chromosome 3 at 66,994,605 bp
  • C to A, chromosome 3 at 95,240,491 bp
  • A to T, chromosome 3 at 154,261,373 bp
  • A to G, chromosome 5 at 114,127,552 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • T to C, chromosome 6 at 113,119,584 bp
  • A to T, chromosome 7 at 106,790,279 bp
  • A to T, chromosome 7 at 108,255,832 bp
  • T to C, chromosome 7 at 128,007,908 bp
  • G to T, chromosome 7 at 128,144,700 bp
  • A to G, chromosome 7 at 134,744,322 bp
  • G to A, chromosome 8 at 49,495,496 bp
  • CAAAAA to CAAAA, chromosome 8 at 84,716,247 bp
  • A to G, chromosome 8 at 121,888,400 bp
  • A to T, chromosome 9 at 19,783,790 bp
  • A to T, chromosome 9 at 21,795,568 bp
  • A to T, chromosome 9 at 52,115,699 bp
  • G to A, chromosome 9 at 104,228,921 bp
  • C to T, chromosome 10 at 34,591,872 bp
  • T to C, chromosome 10 at 45,067,340 bp
  • G to T, chromosome 10 at 45,067,362 bp
  • A to G, chromosome 10 at 81,361,097 bp
  • T to A, chromosome 11 at 26,547,915 bp
  • A to G, chromosome 11 at 71,025,656 bp
  • G to T, chromosome 11 at 77,829,708 bp
  • A to T, chromosome 11 at 83,212,770 bp
  • C to T, chromosome 11 at 110,050,982 bp
  • C to A, chromosome 11 at 121,221,149 bp
  • T to C, chromosome 13 at 58,860,240 bp
  • T to A, chromosome 13 at 108,267,370 bp
  • A to T, chromosome 14 at 7,915,374 bp
  • C to T, chromosome 14 at 88,468,179 bp
  • T to A, chromosome 15 at 25,726,415 bp
  • A to G, chromosome 15 at 89,549,594 bp
  • A to T, chromosome 16 at 29,541,250 bp
  • T to C, chromosome 17 at 28,899,529 bp
  • A to G, chromosome 17 at 42,667,586 bp
  • T to A, chromosome 17 at 74,626,980 bp
  • G to A, chromosome 19 at 23,975,629 bp
  • C to T, chromosome 19 at 23,975,638 bp
  • C to T, chromosome X at 33,505,784 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4163 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041006-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.