Strain Name:
C57BL/6J-MtgxR4191Btlr/Mmmh
Stock Number:
041022-MU
Citation ID:
RRID:MMRRC_041022-MU
Other Names:
R4191 (G1), C57BL/6J-MtgxR4191Btlr
Major Collection:

Gene Information

Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, D030049L12Rik, b2b2679Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66860
Homologene: 18946
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228012
Homologene: 130657
Cdx1
Name: caudal type homeobox 1
Synonyms: Cdx-1, Cdx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12590
HGNC: HGNC:1805
Homologene: 1366
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: FLAP (FLI LRR associated protein), Fliiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170935
Homologene: 15781
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p67MBP, p160MBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: JNK-interacting protein 3, Jip3, JSAP1, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, sunday driver 2, Syd2, D17Wsu15e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Zfyve19
Name: zinc finger, FYVE domain containing 19
Synonyms: 1500041L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72008
Homologene: 12435
Vit
Name: vitrin
Synonyms: 1700110E08Rik, 1700052E02Rik, 2810429K11Rik, AKH, akhirin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: HZF-3, RNR-1, Nurr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93705
Homologene: 81868
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56523
Homologene: 23182
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18795
Homologene: 22876
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MyHC-IIa, MHC2A, Myhs-f1, Myhs-f, Myhsf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Pcsk6
Name: proprotein convertase subtilisin/kexin type 6
Synonyms: PACE4, SPC4, b2b2830Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18553
HGNC: HGNC:8569
Homologene: 20569
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74711
Homologene: 41769
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Pex10
Name: peroxisomal biogenesis factor 10
Synonyms: LOC230983, peroxisome biogenesis factor 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 668173
HGNC: HGNC:8851
Homologene: 5671
Prodh
Name: proline dehydrogenase
Synonyms: Pro1, Pro-1, Ym24d07
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19125
HGNC: HGNC:9453
Homologene: 40764
Olfr1384
Name: olfactory receptor 1384
Synonyms: GA_x6K02T2QP88-5922712-5921756, MOR256-23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258464
Homologene: 74259
Trp53rkb
Name: transformation related protein 53 regulating kinase B
Synonyms: PRPK, mNori-2p, 4933401B08Rik, Nori-2, 5630401H01Rik, Trp53rk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76367
Homologene: 6042
Olfr251
Name: olfactory receptor 251
Synonyms: GA_x6K02T2MYUG-9124-8183, MOR170-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Abcc1
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Pgf
Name: placental growth factor
Synonyms: PLGF, PIGF, placenta growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18654
VEGA: 12
HGNC: HGNC:8893
Homologene: 1978
Mrgpra4
Name: MAS-related GPR, member A4
Synonyms: MrgA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 235854
Homologene: 131159
Ro60
Name: Ro60, Y RNA binding protein
Synonyms: SS-A/Ro, Ssa, A530054J02Rik, 1810007I17Rik, Ssa2, Trove2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20822
Homologene: 3383
Klrb1
Name: killer cell lectin-like receptor subfamily B member 1
Synonyms: Ly-55, Ly55, Gm4696, 4930431A04Rik, Nkrp1g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043861
Homologene: 135763
Ddx19b
Name: DEAD box helicase 19b
Synonyms: 4921519L13Rik, 2810457M08Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234733
HGNC: HGNC:2742
Homologene: 56032
Olfr843
Name: olfactory receptor 843
Synonyms: GA_x6K02T2PVTD-12986331-12985390, MOR155-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258560
Homologene: 74251
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: apoER2, 4932703M08Rik, Lr8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: 9230101H05Rik, Miwi2, MIWI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330890
Homologene: 45122
Donson
Name: downstream neighbor of SON
Synonyms: Donson, 1110025J21Rik, ORF60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 60364
HGNC: HGNC:2993
Homologene: 32350
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57745
Homologene: 49338
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, WI-18508, Nope, WI-16786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TbetaR-II, TbetaRII, 1110020H15Rik, TBR-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
1700001C19Rik
Name: RIKEN cDNA 1700001C19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75462
Homologene: 129540
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433586
Homologene: 41284
Olfr934
Name: olfactory receptor 934
Synonyms: GA_x6K02T2PVTD-32678895-32677963, MOR224-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258434
VEGA: 9
Homologene: 51730
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68897
Homologene: 14133
Olfr1049
Name: olfactory receptor 1049
Synonyms: GA_x6K02T2Q125-47735396-47734470, MOR187-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259018
Homologene: 77387
Gpr160
Name: G protein-coupled receptor 160
Synonyms: 1700025D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71862
Homologene: 8659
Irf2bp2
Name: interferon regulatory factor 2 binding protein 2
Synonyms: E130305N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270110
Homologene: 34290
Cyct
Name: cytochrome c, testis
Synonyms: T-Cc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13067
Homologene: 129551
Gm16153
Name: predicted gene 16153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
H2-Ea
Name: histocompatibility 2, class II antigen E alpha
Synonyms: H-2Ea, Ia-3, Ia3, I-Ealpha, H2-Ea-ps
Type: Pseudogene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 91,110,399 bp
  • T to C, chromosome 1 at 143,770,786 bp
  • G to T, chromosome 1 at 183,089,173 bp
  • T to C, chromosome 2 at 57,112,379 bp
  • A to G, chromosome 2 at 59,839,013 bp
  • G to A, chromosome 2 at 70,725,547 bp
  • G to T, chromosome 2 at 76,354,191 bp
  • C to A, chromosome 2 at 86,255,322 bp
  • A to G, chromosome 2 at 119,210,831 bp
  • A to C, chromosome 2 at 135,345,090 bp
  • A to G, chromosome 2 at 153,003,007 bp
  • A to G, chromosome 2 at 155,633,399 bp
  • T to C, chromosome 2 at 166,795,475 bp
  • A to T, chromosome 3 at 30,896,714 bp
  • A to G, chromosome 3 at 51,689,969 bp
  • C to T, chromosome 4 at 58,046,601 bp
  • T to C, chromosome 4 at 107,855,746 bp
  • A to G, chromosome 4 at 123,473,042 bp
  • T to C, chromosome 4 at 155,067,905 bp
  • A to T, chromosome 5 at 137,291,072 bp
  • G to T, chromosome 5 at 143,377,615 bp
  • T to A, chromosome 6 at 128,713,634 bp
  • A to G, chromosome 7 at 24,126,143 bp
  • T to C, chromosome 7 at 47,981,119 bp
  • T to C, chromosome 7 at 66,025,308 bp
  • C to G, chromosome 8 at 83,938,940 bp
  • T to C, chromosome 8 at 102,650,748 bp
  • A to T, chromosome 8 at 109,527,628 bp
  • A to T, chromosome 8 at 111,011,348 bp
  • T to C, chromosome 8 at 126,593,345 bp
  • A to G, chromosome 9 at 14,715,000 bp
  • A to G, chromosome 9 at 19,249,087 bp
  • T to A, chromosome 9 at 38,378,352 bp
  • T to A, chromosome 9 at 38,983,017 bp
  • A to G, chromosome 9 at 65,124,151 bp
  • T to C, chromosome 9 at 116,109,941 bp
  • A to T, chromosome 10 at 4,410,809 bp
  • T to A, chromosome 11 at 49,513,812 bp
  • A to G, chromosome 11 at 67,177,400 bp
  • A to G, chromosome 11 at 72,451,287 bp
  • T to C, chromosome 12 at 85,171,787 bp
  • T to C, chromosome 14 at 50,836,806 bp
  • T to C, chromosome 15 at 47,847,271 bp
  • A to G, chromosome 16 at 14,389,864 bp
  • C to T, chromosome 16 at 18,073,640 bp
  • G to T, chromosome 16 at 22,046,667 bp
  • C to A, chromosome 16 at 91,688,592 bp
  • C to T, chromosome 17 at 24,901,519 bp
  • G to A, chromosome 17 at 34,344,555 bp
  • C to T, chromosome 17 at 47,436,637 bp
  • A to G, chromosome 17 at 78,586,826 bp
  • G to C, chromosome 18 at 37,763,541 bp
  • C to T, chromosome 18 at 61,020,438 bp
  • T to C, chromosome 19 at 30,145,658 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4191 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041022-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.