Strain Name:
C57BL/6J-MtgxR4191Btlr/Mmmh
Stock Number:
041022-MU
Citation ID:
RRID:MMRRC_041022-MU
Other Names:
R4191 (G1), C57BL/6J-MtgxR4191Btlr
Major Collection:

Strain Information

Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, Cad11, OB-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, b2b2679Clo, D19Wsu57e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228012
Homologene: 130657
Cdx1
Name: caudal type homeobox 1
Synonyms: Cdx-1, Cdx
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12590
HGNC: HGNC:1805
Homologene: 1366
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: Fliiap1, FLAP (FLI LRR associated protein)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lphn1, lectomedin-2, Lec2, 2900070I05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170935
Homologene: 15781
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p160MBP, p67MBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: Syd2, Jip3, JNK-interacting protein 3, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, JSAP1, sunday driver 2, D17Wsu15e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Zfyve19
Name: zinc finger, FYVE domain containing 19
Synonyms: 1500041L05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72008
Homologene: 12435
Vit
Name: vitrin
Synonyms: 2810429K11Rik, akhirin, 1700110E08Rik, AKH, 1700052E02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: RNR-1, Nurr1, HZF-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93705
Homologene: 81868
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18795
Homologene: 22876
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhs-f, MyHC-IIa, MHC2A, Myhsf1, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Pcsk6
Name: proprotein convertase subtilisin/kexin type 6
Synonyms: SPC4, PACE4, b2b2830Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18553
HGNC: HGNC:8569
Homologene: 20569
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Pex10
Name: peroxisomal biogenesis factor 10
Synonyms: LOC230983, peroxisome biogenesis factor 10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 668173
HGNC: HGNC:8851
Homologene: 5671
Prodh
Name: proline dehydrogenase
Synonyms: Pro1, Pro-1, Ym24d07
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19125
HGNC: HGNC:9453
Homologene: 40764
Or2y14
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: Olfr1384, GA_x6K02T2QP88-5922712-5921756, MOR256-23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258464
Homologene: 74259
Trp53rkb
Name: transformation related protein 53 regulating kinase B
Synonyms: mNori-2p, 5630401H01Rik, Trp53rk, Nori-2, 4933401B08Rik, PRPK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76367
Homologene: 6042
Or8c11
Name: olfactory receptor family 8 subfamily C member 11
Synonyms: GA_x6K02T2PVTD-32071567-32072508, MOR170-13, MOR170-15, MOR170-2, Olfr900, Olfr251, GA_x6K02T2MYUG-9124-8183
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Pgf
Name: placental growth factor
Synonyms: PLGF, PIGF, placenta growth factor
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18654
VEGA: 12
HGNC: HGNC:8893
Homologene: 1978
Mrgpra4
Name: MAS-related GPR, member A4
Synonyms: MrgA4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 235854
Homologene: 131159
Ro60
Name: Ro60, Y RNA binding protein
Synonyms: 1810007I17Rik, SS-A/Ro, Trove2, Ssa2, Ssa, A530054J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20822
Homologene: 3383
Klrb1
Name: killer cell lectin-like receptor subfamily B member 1
Synonyms: Ly55, 4930431A04Rik, Nkrp1g, Gm4696, Ly-55
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100043861
HGNC: HGNC:6373
Homologene: 135763
Ddx19b
Name: DEAD box helicase 19b
Synonyms: 2810457M08Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b, 4921519L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234733
HGNC: HGNC:2742
Homologene: 56032
Or7g25
Name: olfactory receptor family 7 subfamily G member 25
Synonyms: Olfr843, MOR155-2, GA_x6K02T2PVTD-12986331-12985390
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258560
HGNC: HGNC:8466
Homologene: 74251
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: Lr8b, 4932703M08Rik, apoER2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: Miwi2, MIWI2, 9230101H05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Donson
Name: downstream neighbor of SON
Synonyms: ORF60, Donson, 1110025J21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 60364
HGNC: HGNC:2993
Homologene: 32350
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: Nope, 9330155G14Rik, WI-16786, WI-18508
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TBR-II, TbetaRII, TbetaR-II, 1110020H15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Cimip3
Name: ciliary microtubule inner protein 3
Synonyms: 1700001C19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75462
Homologene: 129540
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Or10d1c
Name: olfactory receptor family 10 subfamily D member 1C
Synonyms: GA_x6K02T2PVTD-32678895-32677963, Olfr934, MOR224-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258434
VEGA: 9
Homologene: 51730
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68897
Homologene: 14133
Or8k18
Name: olfactory receptor family 8 subfamily K member 18
Synonyms: MOR187-1, Olfr1049, GA_x6K02T2Q125-47735396-47734470
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259018
Homologene: 77387
Gpr160
Name: G protein-coupled receptor 160
Synonyms: 1700025D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71862
Homologene: 8659
Irf2bp2
Name: interferon regulatory factor 2 binding protein 2
Synonyms: E130305N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270110
Homologene: 34290
Cyct
Name: cytochrome c, testis
Synonyms: T-Cc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13067
Homologene: 129551
Gm16153
Name: predicted gene 16153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
H2-Ea
Name: histocompatibility 2, class II antigen E alpha
Synonyms: Ia-3, I-Ealpha, H2-Ea-ps, H-2Ea, Ia3
Type: Pseudogene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 91,110,399 bp
  • T to C, chromosome 1 at 143,770,786 bp
  • G to T, chromosome 1 at 183,089,173 bp
  • T to C, chromosome 2 at 57,112,379 bp
  • A to G, chromosome 2 at 59,839,013 bp
  • G to A, chromosome 2 at 70,725,547 bp
  • G to T, chromosome 2 at 76,354,191 bp
  • C to A, chromosome 2 at 86,255,322 bp
  • A to G, chromosome 2 at 119,210,831 bp
  • A to C, chromosome 2 at 135,345,090 bp
  • A to G, chromosome 2 at 153,003,007 bp
  • A to G, chromosome 2 at 155,633,399 bp
  • T to C, chromosome 2 at 166,795,475 bp
  • A to T, chromosome 3 at 30,896,714 bp
  • A to G, chromosome 3 at 51,689,969 bp
  • C to T, chromosome 4 at 58,046,601 bp
  • T to C, chromosome 4 at 107,855,746 bp
  • A to G, chromosome 4 at 123,473,042 bp
  • T to C, chromosome 4 at 155,067,905 bp
  • A to T, chromosome 5 at 137,291,072 bp
  • G to T, chromosome 5 at 143,377,615 bp
  • T to A, chromosome 6 at 128,713,634 bp
  • A to G, chromosome 7 at 24,126,143 bp
  • T to C, chromosome 7 at 47,981,119 bp
  • T to C, chromosome 7 at 66,025,308 bp
  • C to G, chromosome 8 at 83,938,940 bp
  • T to C, chromosome 8 at 102,650,748 bp
  • A to T, chromosome 8 at 109,527,628 bp
  • A to T, chromosome 8 at 111,011,348 bp
  • T to C, chromosome 8 at 126,593,345 bp
  • A to G, chromosome 9 at 14,715,000 bp
  • A to G, chromosome 9 at 19,249,087 bp
  • T to A, chromosome 9 at 38,378,352 bp
  • T to A, chromosome 9 at 38,983,017 bp
  • A to G, chromosome 9 at 65,124,151 bp
  • T to C, chromosome 9 at 116,109,941 bp
  • A to T, chromosome 10 at 4,410,809 bp
  • T to A, chromosome 11 at 49,513,812 bp
  • A to G, chromosome 11 at 67,177,400 bp
  • A to G, chromosome 11 at 72,451,287 bp
  • T to C, chromosome 12 at 85,171,787 bp
  • T to C, chromosome 14 at 50,836,806 bp
  • T to C, chromosome 15 at 47,847,271 bp
  • A to G, chromosome 16 at 14,389,864 bp
  • C to T, chromosome 16 at 18,073,640 bp
  • G to T, chromosome 16 at 22,046,667 bp
  • C to A, chromosome 16 at 91,688,592 bp
  • C to T, chromosome 17 at 24,901,519 bp
  • G to A, chromosome 17 at 34,344,555 bp
  • C to T, chromosome 17 at 47,436,637 bp
  • A to G, chromosome 17 at 78,586,826 bp
  • G to C, chromosome 18 at 37,763,541 bp
  • C to T, chromosome 18 at 61,020,438 bp
  • T to C, chromosome 19 at 30,145,658 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4191 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041022-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.