Strain Name:
C57BL/6J-MtgxR4206Btlr/Mmmh
Stock Number:
041035-MU
Citation ID:
RRID:MMRRC_041035-MU
Other Names:
R4206 (G1), C57BL/6J-MtgxR4206Btlr
Major Collection:

Gene Information

Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22173
Homologene: 30969
Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Ntsr1
Name: neurotensin receptor 1
Synonyms: NT-1R, Ntsr1, NTR-1, NTR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76707
Homologene: 41024
Nudt3
Name: nudix (nucleotide diphosphate linked moiety X)-type motif 3
Synonyms: diphosphoinositol polyphosphate phosphohydrolase, Dipp, 1110011B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56409
HGNC: HGNC:8050
Homologene: 31400
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81000
Homologene: 56698
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217342
Homologene: 11113
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: 2410002G23Rik, D13Ertd328e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69716
Homologene: 3125
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Srsf3
Name: serine and arginine-rich splicing factor 3
Synonyms: X16, Sfrs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20383
Homologene: 55708
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 84585
Homologene: 11112
Eif2d
Name: eukaryotic translation initiation factor 2D
Synonyms: D1Ertd5e, Lgtn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16865
HGNC: HGNC:6583
Homologene: 38244
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810004P07Rik, 1810035F16Rik, 0610009H19Rik, 9130416J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Aamp
Name: angio-associated migratory protein
Synonyms: Aamp-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227290
HGNC: HGNC:18
Homologene: 846
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Csrp1
Name: cysteine and glycine-rich protein 1
Synonyms: CRP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13007
HGNC: HGNC:2469
Homologene: 37874
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Gin1
Name: gypsy retrotransposon integrase 1
Synonyms: 4930429M06, 4930429M06Rik, Zh2c2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 252876
Homologene: 69238
Tsku
Name: tsukushi, small leucine rich proteoglycan
Synonyms: 9530051K01Rik, Lrrc54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244152
Homologene: 41045
Ell2
Name: elongation factor for RNA polymerase II 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 192657
VEGA: 13
Homologene: 8094
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, A230065J02Rik, Ugcgl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Rufy2
Name: RUN and FYVE domain-containing 2
Synonyms: LZ-FYVE, 2610111M19Rik, Denn, ZFYVE13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70432
Homologene: 23064
Pex6
Name: peroxisomal biogenesis factor 6
Synonyms: D130055I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224824
HGNC: HGNC:8859
Homologene: 47914
Hpx
Name: hemopexin
Synonyms: hx, Hpxn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15458
HGNC: HGNC:5171
Homologene: 511
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Prpf19
Name: pre-mRNA processing factor 19
Synonyms: PSO4, D19Wsu55e, Prp19, Snev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 28000
Homologene: 6421
Olfr1410
Name: olfactory receptor 1410
Synonyms: GA_x6K02T2R7CC-81146179-81145211, MOR208-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258484
Homologene: 74205
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Rcn2
Name: reticulocalbin 2
Synonyms: taipoxin-associated calcium binding protein 49, TCBP-49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26611
HGNC: HGNC:9935
Homologene: 2176
4921509C19Rik
Name: RIKEN cDNA 4921509C19 gene
Synonyms: LOC381389
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381393
Homologene: 72396
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Wnt4
Name: wingless-type MMTV integration site family, member 4
Synonyms: Wnt-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22417
Homologene: 22529
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: Roct, OAT3, mOat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19879
VEGA: 19
Homologene: 20901
Edil3
Name: EGF-like repeats and discoidin I-like domains 3
Synonyms: Del1, developmental endothelial locus-1, Del-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13612
HGNC: HGNC:3173
Homologene: 21166
Gpr149
Name: G protein-coupled receptor 149
Synonyms: PGR10, 9630018L10Rik, Ieda, R35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229357
Homologene: 16359
Acat3
Name: acetyl-Coenzyme A acetyltransferase 3
Synonyms: ACTL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224530
HGNC: HGNC:94
Homologene: 55855
Olfr8
Name: olfactory receptor 8
Synonyms: MOR139-5P, GA_x6K02T2QGN0-2857086-2856154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18372
Homologene: 136441
Gyg
Name: glycogenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 27357
HGNC: HGNC:4699
Homologene: 31219
Fam187a
Name: family with sequence similarity 187, member A
Synonyms: 4933439F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66784
Homologene: 128440
Olfr657
Name: olfactory receptor 657
Synonyms: GA_x6K02T2PBJ9-7263864-7264823, MOR40-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258309
Homologene: 17189
Dpf1
Name: D4, zinc and double PHD fingers family 1
Synonyms: neuro-d4, Neud4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29861
Homologene: 3415
Scrn3
Name: secernin 3
Synonyms: 4833415E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74616
Homologene: 11601
Tex11
Name: testis expressed gene 11
Synonyms: 4930565P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 83558
Homologene: 49962
Scgb2b12
Name: secretoglobin, family 2B, member 12
Synonyms: Gm9138, Abpbg12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668379
Homologene: 83171
Gm15462
Name: predicted gene 15462
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108168861
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 34,212,247 bp
  • G to A, chromosome 1 at 74,282,528 bp
  • A to C, chromosome 1 at 92,608,595 bp
  • A to G, chromosome 1 at 97,792,420 bp
  • A to G, chromosome 1 at 118,578,906 bp
  • A to G, chromosome 1 at 131,154,363 bp
  • T to G, chromosome 1 at 135,745,327 bp
  • T to A, chromosome 2 at 73,319,501 bp
  • A to G, chromosome 2 at 76,772,567 bp
  • T to C, chromosome 2 at 151,473,515 bp
  • A to G, chromosome 2 at 180,500,752 bp
  • A to G, chromosome 3 at 20,152,737 bp
  • G to A, chromosome 3 at 28,120,783 bp
  • A to G, chromosome 3 at 30,687,581 bp
  • T to G, chromosome 3 at 62,604,503 bp
  • A to T, chromosome 4 at 81,381,762 bp
  • A to G, chromosome 4 at 137,296,343 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 5 at 114,213,651 bp
  • G to A, chromosome 6 at 60,958,180 bp
  • C to T, chromosome 7 at 29,309,622 bp
  • T to C, chromosome 7 at 32,326,638 bp
  • A to G, chromosome 7 at 87,429,068 bp
  • C to T, chromosome 7 at 98,352,998 bp
  • T to A, chromosome 7 at 104,636,149 bp
  • C to T, chromosome 7 at 105,595,147 bp
  • C to T, chromosome 7 at 141,817,110 bp
  • CAAAAA to CAAAA, chromosome 8 at 84,716,247 bp
  • A to G, chromosome 8 at 107,295,627 bp
  • A to G, chromosome 9 at 56,045,207 bp
  • A to C, chromosome 9 at 106,717,795 bp
  • A to T, chromosome 9 at 108,063,963 bp
  • C to T, chromosome 10 at 63,004,772 bp
  • T to C, chromosome 10 at 75,754,841 bp
  • T to C, chromosome 10 at 78,955,283 bp
  • A to T, chromosome 10 at 128,721,195 bp
  • A to G, chromosome 11 at 102,886,212 bp
  • A to G, chromosome 11 at 106,567,572 bp
  • G to A, chromosome 11 at 116,541,946 bp
  • C to T, chromosome 12 at 86,883,036 bp
  • A to G, chromosome 13 at 13,635,989 bp
  • A to G, chromosome 13 at 73,932,890 bp
  • A to G, chromosome 13 at 75,761,948 bp
  • T to C, chromosome 13 at 89,180,278 bp
  • C to A, chromosome 13 at 95,222,545 bp
  • C to T, chromosome 14 at 119,049,262 bp
  • T to C, chromosome 15 at 83,322,668 bp
  • A to G, chromosome 17 at 12,927,386 bp
  • T to C, chromosome 17 at 27,596,784 bp
  • C to A, chromosome 17 at 29,039,493 bp
  • A to G, chromosome 17 at 46,712,147 bp
  • T to C, chromosome 18 at 54,988,195 bp
  • T to C, chromosome 19 at 8,608,233 bp
  • G to A, chromosome 19 at 10,897,767 bp
  • G to T, chromosome 19 at 21,842,115 bp
  • C to A, chromosome X at 100,933,415 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4206 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041035-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.