Strain Name:
C57BL/6J-MtgxR4209Btlr/Mmmh
Stock Number:
041038-MU
Citation ID:
RRID:MMRRC_041038-MU
Other Names:
R4209 (G1), C57BL/6J-MtgxR4209Btlr
Major Collection:

Gene Information

Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
Synonyms: 2410004D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71978
VEGA: 14
HGNC: HGNC:9304
Homologene: 2035
Cops4
Name: COP9 signalosome subunit 4
Synonyms: COP9 complex S4, D5Ertd774e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26891
Homologene: 8067
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: Riz, Riz1, LOC381568, E330024L24Rik, 4833427P12Rik, KMT8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Trim36
Name: tripartite motif-containing 36
Synonyms: D18Wsu100e, Haprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: 4921509N21Rik, SCAN1, 2810481F14Rik, E430034L06Rik, Gm40556
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104884
Homologene: 5424
Casp3
Name: caspase 3
Synonyms: CPP32, Apopain, Yama, Caspase-3, A830040C14Rik, CC3, mldy, AC-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12367
HGNC: HGNC:1504
Homologene: 37912
Zfyve1
Name: zinc finger, FYVE domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217695
VEGA: 12
Homologene: 10945
Gtf2f1
Name: general transcription factor IIF, polypeptide 1
Synonyms: 2810405L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 98053
VEGA: 17
HGNC: HGNC:4652
Homologene: 1585
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 6330512O03Rik, 2310038O07Rik, D10Ertd516e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71902
Homologene: 10202
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 58996
Homologene: 104145
Fezf1
Name: Fez family zinc finger 1
Synonyms: Zfp312-like, Fez, 3110069A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73191
Homologene: 19252
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pipp, Pib5pa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Tube1
Name: tubulin, epsilon 1
Synonyms: 2310061K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71924
VEGA: 10
Homologene: 17762
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 8030475K17Rik, A330041G23Rik, 2610202E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Irf8
Name: interferon regulatory factor 8
Synonyms: IRF-8, ICSBP, Myls, Icsbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 665113
Homologene: 77943
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 277973
Homologene: 31247
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Octn3, Slc22a9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56517
Homologene: 137336
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Sec11a
Name: SEC11 homolog A, signal peptidase complex subunit
Synonyms: sid2895, 18kDa, 1810012E07Rik, Spc18, Sec11l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56529
Homologene: 55536
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72137
Homologene: 17609
Bean1
Name: brain expressed, associated with Nedd4, 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65115
Homologene: 110172
Ybx2
Name: Y box protein 2
Synonyms: MSY2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53422
Homologene: 22942
Tmem120a
Name: transmembrane protein 120A
Synonyms: Tmpit, 2010310D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215210
Homologene: 12907
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230815
Homologene: 69303
Hnf4a
Name: hepatic nuclear factor 4, alpha
Synonyms: HNF-4, Nr2a1, Nuclear receptor 2A1, HNF4 alpha, Tcf14, MODY1, Tcf4, Hnf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15378
HGNC: HGNC:5024
Homologene: 395
Tcn2
Name: transcobalamin 2
Synonyms: Tcn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21452
Homologene: 303
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72046
Homologene: 69243
Vmn1r113
Name: vomeronasal 1 receptor 113
Synonyms: Gm5748
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 436135
Homologene: 104166
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: Veph, 2810471M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72789
Homologene: 11624
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 5830443C21Rik, 9530023M17Rik, 1110054A01Rik, 0610009F02Rik, 5830406C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
Dpysl2
Name: dihydropyrimidinase-like 2
Synonyms: Ulip2, Crmp2, TOAD-64, DRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12934
HGNC: HGNC:3014
Homologene: 74392
Slc38a3
Name: solute carrier family 38, member 3
Synonyms: 0610012J02Rik, D9Ucla2, Snat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76257
Homologene: 4983
Sesn3
Name: sestrin 3
Synonyms: SEST3, 5630400E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75747
Homologene: 14386
Gm10272
Name: predicted gene 10272
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16697
VEGA: 10
Spns2
Name: spinster homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216892
Homologene: 71040
Mcpt8
Name: mast cell protease 8
Synonyms: MMCP-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17231
VEGA: 14
Mycl
Name: v-myc avian myelocytomatosis viral oncogene lung carcinoma derived
Synonyms: Lmyc-1, Lmyc1, L-myc, bHLHe38, Mycl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16918
HGNC: HGNC:7555
Homologene: 3921
Tex16
Name: testis expressed gene 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 83556
Homologene: 130788
Aadacl2fm3
Name: AADACL2 family member 3
Synonyms: Gm8298
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 666803
Homologene: 86204
Vmn1r152
Name: vomeronasal 1 receptor 152
Synonyms: Gm8673
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667504
Homologene: 104166
Gm21971
Name: predicted gene 21971
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 59,876,805 bp
  • T to C, chromosome 2 at 163,568,889 bp
  • A to T, chromosome 3 at 28,359,065 bp
  • A to T, chromosome 3 at 59,877,156 bp
  • A to T, chromosome 3 at 66,244,546 bp
  • A to G, chromosome 3 at 97,209,953 bp
  • G to T, chromosome 4 at 122,999,922 bp
  • G to C, chromosome 4 at 134,703,438 bp
  • T to C, chromosome 4 at 143,134,437 bp
  • T to A, chromosome 5 at 100,547,486 bp
  • T to C, chromosome 5 at 135,735,705 bp
  • T to C, chromosome 6 at 23,246,617 bp
  • C to T, chromosome 6 at 41,698,425 bp
  • T to C, chromosome 7 at 20,787,610 bp
  • A to T, chromosome 7 at 22,523,579 bp
  • A to T, chromosome 7 at 80,935,042 bp
  • C to A, chromosome 7 at 81,477,136 bp
  • A to T, chromosome 7 at 105,766,190 bp
  • G to T, chromosome 8 at 46,635,388 bp
  • T to A, chromosome 8 at 104,213,934 bp
  • A to G, chromosome 8 at 105,358,471 bp
  • T to A, chromosome 8 at 120,753,469 bp
  • T to C, chromosome 9 at 14,306,209 bp
  • T to G, chromosome 9 at 107,655,348 bp
  • A to G, chromosome 10 at 39,144,934 bp
  • T to C, chromosome 10 at 77,706,831 bp
  • T to A, chromosome 10 at 119,211,558 bp
  • T to G, chromosome 11 at 3,501,107 bp
  • T to C, chromosome 11 at 3,922,114 bp
  • C to A, chromosome 11 at 5,715,878 bp
  • A to G, chromosome 11 at 53,956,055 bp
  • G to T, chromosome 11 at 69,935,941 bp
  • T to C, chromosome 11 at 72,454,186 bp
  • C to A, chromosome 11 at 97,454,496 bp
  • A to T, chromosome 12 at 83,575,135 bp
  • C to A, chromosome 12 at 99,898,329 bp
  • A to G, chromosome 12 at 102,674,884 bp
  • G to A, chromosome 14 at 56,083,918 bp
  • T to C, chromosome 14 at 66,815,477 bp
  • A to G, chromosome 14 at 67,028,879 bp
  • A to G, chromosome 17 at 57,011,003 bp
  • A to G, chromosome 18 at 46,196,124 bp
  • G to A, chromosome 19 at 9,002,600 bp
  • C to A, chromosome 19 at 36,437,340 bp
  • T to A, chromosome X at 112,120,943 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4209 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041038-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.