Strain Name:
C57BL/6J-MtgxR4238Btlr/Mmmh
Stock Number:
041055-MU
Citation ID:
RRID:MMRRC_041055-MU
Other Names:
R4238 (G1), C57BL/6J-MtgxR4238Btlr
Major Collection:

Strain Information

Aar2
Name: AAR2 splicing factor homolog
Synonyms: 0610011L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68295
Homologene: 9170
Gtf2h1
Name: general transcription factor II H, polypeptide 1
Synonyms: p62, 62kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14884
HGNC: HGNC:4655
Homologene: 3885
Prc1
Name: protein regulator of cytokinesis 1
Synonyms: D7Ertd348e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233406
HGNC: HGNC:9341
Homologene: 37868
4833420G17Rik
Name: RIKEN cDNA 4833420G17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67392
VEGA: 13
Homologene: 18889
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Lin54
Name: lin-54 DREAM MuvB core complex component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231506
Homologene: 18212
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320806
Homologene: 6238
Lzts1
Name: leucine zipper, putative tumor suppressor 1
Synonyms: F37, FEZ1, PSD-Zip70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 211134
Homologene: 10873
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Tax1bp1
Name: Tax1 (human T cell leukemia virus type I) binding protein 1
Synonyms: D6Ertd404e, 1200003J11Rik, TXBP151, T6BP, D6Ertd772e, 1700069J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 52440
Homologene: 4395
Cdc20
Name: cell division cycle 20
Synonyms: p55CDC, 2310042N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107995
HGNC: HGNC:1723
Homologene: 37459
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Actmap
Name: actin maturation protease
Synonyms: BC024978
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 414069
Homologene: 45689
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
C030017K20Rik
Name: RIKEN cDNA C030017K20 gene
Synonyms: LOC381581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Mrgprx2
Name: MAS-related GPR, member X2
Synonyms: MrgB10, Mrgprb10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243978
Homologene: 24986
Otud7a
Name: OTU domain containing 7A
Synonyms: Cezanne 2 protein, Otud7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 170711
Homologene: 15642
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: 2310045L10Rik, Srcasm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71943
Homologene: 38055
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: Rpel1, 9630030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218194
Homologene: 33597
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Gm16069
Name: predicted gene 16069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 102636781
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Psg20
Name: pregnancy-specific beta-1-glycoprotein 20
Synonyms: cea7, EG434540
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434540
HGNC: HGNC:1816
Homologene: 110989
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319734
Homologene: 26544
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319719
Homologene: 131217
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: Neu, Neu oncogene, c-erbB2, HER-2, ErbB-2, HER2, c-neu, l11Jus8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Cpz
Name: carboxypeptidase Z
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242939
HGNC: HGNC:2333
Homologene: 2709
Klk6
Name: kallikrein related-peptidase 6
Synonyms: Bssp, protease M, neurosin, Prss9, Klk29, Prss18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19144
HGNC: HGNC:6367
Homologene: 68279
Cers3
Name: ceramide synthase 3
Synonyms: T3L, related to TRH3, LOC233330, CerS3, 4930550L11Rik, Lass3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545975
Homologene: 18719
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102642386
Or4k15
Name: olfactory receptor family 4 subfamily K member 15
Synonyms: GA_x6K02T2PMLR-5817082-5818056, MOR246-2, Olfr727
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258316
Homologene: 84571
Sval2
Name: seminal vesicle antigen-like 2
Synonyms: SLP-M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 84543
Homologene: 13055
Mlf1
Name: myeloid leukemia factor 1
Synonyms: HLS7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17349
HGNC: HGNC:7125
Homologene: 7839
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Igkv12-44
Name: immunoglobulin kappa variable 12-44
Synonyms: Gm16851
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545851
Ighv3-4
Name: immunoglobulin heavy variable V3-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629833
Zfp433
Name: zinc finger protein 433
Synonyms: 1700123A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73610
Homologene: 117476
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 14,884,116 bp
  • T to C, chromosome 1 at 105,827,237 bp
  • G to T, chromosome 2 at 21,368,551 bp
  • A to G, chromosome 2 at 156,551,144 bp
  • G to A, chromosome 3 at 67,384,577 bp
  • G to A, chromosome 3 at 89,181,927 bp
  • C to T, chromosome 4 at 118,433,060 bp
  • C to A, chromosome 4 at 155,463,072 bp
  • T to C, chromosome 5 at 35,502,474 bp
  • G to A, chromosome 5 at 100,475,744 bp
  • T to A, chromosome 6 at 41,860,349 bp
  • C to T, chromosome 6 at 52,766,051 bp
  • A to G, chromosome 6 at 69,814,884 bp
  • A to G, chromosome 6 at 119,240,708 bp
  • A to T, chromosome 7 at 18,684,509 bp
  • A to T, chromosome 7 at 27,192,868 bp
  • G to T, chromosome 7 at 41,545,780 bp
  • A to G, chromosome 7 at 43,829,173 bp
  • C to T, chromosome 7 at 46,805,065 bp
  • C to A, chromosome 7 at 48,482,990 bp
  • A to G, chromosome 7 at 63,650,954 bp
  • T to C, chromosome 7 at 66,773,676 bp
  • G to A, chromosome 7 at 80,311,216 bp
  • G to T, chromosome 8 at 69,135,927 bp
  • T to C, chromosome 9 at 44,939,999 bp
  • T to C, chromosome 9 at 55,980,842 bp
  • A to G, chromosome 9 at 65,054,923 bp
  • A to C, chromosome 10 at 81,720,212 bp
  • A to G, chromosome 11 at 69,347,189 bp
  • G to T, chromosome 11 at 90,658,201 bp
  • A to G, chromosome 11 at 98,428,043 bp
  • A to T, chromosome 12 at 114,253,913 bp
  • T to A, chromosome 13 at 43,094,887 bp
  • C to G, chromosome 13 at 54,526,260 bp
  • T to C, chromosome 13 at 97,176,751 bp
  • C to T, chromosome 13 at 119,466,942 bp
  • T to C, chromosome 14 at 50,127,432 bp
  • T to C, chromosome 15 at 99,943,642 bp
  • G to T, chromosome 16 at 37,013,181 bp
  • G to A, chromosome 18 at 78,207,068 bp
  • G to T, chromosome 18 at 84,618,217 bp
  • A to G, chromosome 19 at 22,978,638 bp
  • T to A, chromosome 19 at 37,923,008 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4238 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041055-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.