Strain Name:
C57BL/6J-MtgxR4240Btlr/Mmmh
Stock Number:
041057-MU
Citation ID:
RRID:MMRRC_041057-MU
Other Names:
R4240 (G1), C57BL/6J-MtgxR4240Btlr
Major Collection:

Gene Information

Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Areg
Name: amphiregulin
Synonyms: AR, Sdgf, Mcub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11839
HGNC: HGNC:651
Homologene: 1252
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 2410018I08Rik, 1190009E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69727
Homologene: 56957
Med15
Name: mediator complex subunit 15
Synonyms: A230074L19Rik, Pcqap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 94112
VEGA: 16
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Prc1
Name: protein regulator of cytokinesis 1
Synonyms: D7Ertd348e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233406
HGNC: HGNC:9341
Homologene: 37868
Cog7
Name: component of oligomeric golgi complex 7
Synonyms: 5630400E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233824
Homologene: 33431
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
4833420G17Rik
Name: RIKEN cDNA 4833420G17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67392
VEGA: 13
Homologene: 18889
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: mCdc21, Cdc21, Mcmd4, 19G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Zfp870
Name: zinc finger protein 870
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240066
VEGA: 17
Homologene: 48189
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212124
C030017K20Rik
Name: RIKEN cDNA C030017K20 gene
Synonyms: LOC381581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Zfp791
Name: zinc finger protein 791
Synonyms: EG244556
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244556
Homologene: 27420
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Eno1b
Name: enolase 1B, retrotransposed
Synonyms: Gm5506
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433182
VEGA: 18
HGNC: HGNC:3350
Homologene: 134343
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233204
Homologene: 11656
Zbtb38
Name: zinc finger and BTB domain containing 38
Synonyms: A930014K01Rik, Zenon homolog, CIBZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245007
Homologene: 19529
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110893
Homologene: 62645
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: 2310045L10Rik, Srcasm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71943
Homologene: 38055
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: Rpel1, 9630030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218194
Homologene: 33597
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: C80743, 2310067L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69700
Homologene: 43567
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: 1810012I01Rik, CIP85, Rutbc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105835
Homologene: 9249
Hsf4
Name: heat shock transcription factor 4
Synonyms: ldis1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26386
HGNC: HGNC:5227
Homologene: 100128
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: Neu, Neu oncogene, c-erbB2, HER-2, ErbB-2, HER2, c-neu, l11Jus8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 260305
Homologene: 9024
Rdh7
Name: retinol dehydrogenase 7
Synonyms: CRAD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54150
Homologene: 137324
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231591
Homologene: 129606
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627479
Homologene: 129606
Klk6
Name: kallikrein related-peptidase 6
Synonyms: Bssp, protease M, neurosin, Prss9, Klk29, Prss18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19144
HGNC: HGNC:6367
Homologene: 68279
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231464
Homologene: 100830
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384557
Homologene: 86971
Mfrp
Name: membrane frizzled-related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259172
Homologene: 12866
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102642386
2310050C09Rik
Name: RIKEN cDNA 2310050C09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66533
Homologene: 104374
Fam170a
Name: family with sequence similarity 170, member A
Synonyms: LOC225497, Znfd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225497
VEGA: 18
Homologene: 86702
Ddi1
Name: DNA-damage inducible 1
Synonyms: 1700011N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71829
VEGA: 9
Homologene: 100549
Mr1
Name: major histocompatibility complex, class I-related
Synonyms: MR1, H2ls
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15064
HGNC: HGNC:4975
Homologene: 123981
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Or13a25
Name: olfactory receptor family 13 subfamily A member 25
Synonyms: GA_x6K02T2PBJ9-42813436-42814368, MOR253-4, Olfr539
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258963
Homologene: 79393
Lad1
Name: ladinin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Gm1979
Name: predicted gene 1979
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100038949
Homologene: 69402
1700095B10Rik
Name: RIKEN cDNA 1700095B10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67360
Gm26996
Name: predicted gene, 26996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Pate10
Name: prostate and testis expressed 10
Synonyms: Gm17677
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100312949
Homologene: 130079
4930488N24Rik
Name: RIKEN cDNA 4930488N24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75011
Homologene: 133217
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 135,827,295 bp
  • T to C, chromosome 1 at 155,136,667 bp
  • C to A, chromosome 3 at 87,979,359 bp
  • T to C, chromosome 3 at 92,868,591 bp
  • G to A, chromosome 4 at 135,929,950 bp
  • A to G, chromosome 4 at 152,555,684 bp
  • C to A, chromosome 4 at 155,463,072 bp
  • T to C, chromosome 5 at 26,001,121 bp
  • T to G, chromosome 5 at 74,032,267 bp
  • A to T, chromosome 5 at 91,143,516 bp
  • T to C, chromosome 5 at 96,077,362 bp
  • A to T, chromosome 5 at 108,797,503 bp
  • T to G, chromosome 5 at 109,216,411 bp
  • A to G, chromosome 5 at 112,803,187 bp
  • A to G, chromosome 6 at 130,579,868 bp
  • A to T, chromosome 7 at 10,381,316 bp
  • G to A, chromosome 7 at 17,160,024 bp
  • G to T, chromosome 7 at 41,545,780 bp
  • A to G, chromosome 7 at 43,829,173 bp
  • T to C, chromosome 7 at 44,846,826 bp
  • G to A, chromosome 7 at 80,311,216 bp
  • C to CGGCGGCGGT, chromosome 7 at 97,579,935 bp
  • C to T, chromosome 7 at 121,925,484 bp
  • G to T, chromosome 7 at 139,666,287 bp
  • A to G, chromosome 7 at 140,667,583 bp
  • A to G, chromosome 8 at 15,132,895 bp
  • T to C, chromosome 8 at 85,109,666 bp
  • A to G, chromosome 8 at 105,274,881 bp
  • T to C, chromosome 8 at 125,491,656 bp
  • A to G, chromosome 9 at 6,265,799 bp
  • T to A, chromosome 9 at 35,742,153 bp
  • T to C, chromosome 9 at 44,102,866 bp
  • CTCTTCTTCTTCTTCTTCTTCTTC to CTCTTCTTCTTCTTCTTCTTC, chromosome 9 at 96,686,102 bp
  • T to C, chromosome 10 at 127,885,802 bp
  • A to G, chromosome 11 at 69,347,189 bp
  • G to T, chromosome 11 at 90,658,201 bp
  • A to G, chromosome 11 at 98,428,043 bp
  • T to C, chromosome 12 at 81,315,176 bp
  • C to A, chromosome 12 at 86,882,917 bp
  • T to A, chromosome 13 at 43,094,887 bp
  • C to T, chromosome 13 at 119,466,942 bp
  • C to T, chromosome 15 at 72,007,131 bp
  • A to G, chromosome 15 at 81,011,782 bp
  • G to A, chromosome 15 at 98,844,571 bp
  • A to T, chromosome 16 at 15,627,706 bp
  • C to T, chromosome 16 at 17,655,494 bp
  • G to T, chromosome 16 at 37,013,181 bp
  • A to T, chromosome 17 at 14,105,787 bp
  • A to G, chromosome 17 at 32,885,736 bp
  • A to G, chromosome 17 at 73,895,795 bp
  • T to A, chromosome 18 at 48,047,840 bp
  • A to T, chromosome 18 at 50,281,667 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4240 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041057-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.