Strain Name:
C57BL/6J-MtgxR4279Btlr/Mmmh
Stock Number:
041079-MU
Citation ID:
RRID:MMRRC_041079-MU
Other Names:
R4279 (G1), C57BL/6J-MtgxR4279Btlr
Major Collection:

Gene Information

Nos2
Name: nitric oxide synthase 2, inducible
Synonyms: iNOS, Nos2a, NOS-II, Nos-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18126
VEGA: 11
HGNC: HGNC:7873
Homologene: 55473
Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67800
VEGA: 7
Homologene: 23580
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LR3, LRP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16973
VEGA: 19
HGNC: HGNC:6697
Homologene: 1746
Kif13b
Name: kinesin family member 13B
Synonyms: N-3 kinesin, GAKIN, 5330429L19Rik, C130021D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16554
VEGA: 14
Homologene: 9073
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: zipzap/p200, 4432409D24Rik, 1700124K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 77044
VEGA: 15
Homologene: 14601
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: Edg2, vzg-1, LPA1, Kdt2, Gpcr26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14745
VEGA: 4
HGNC: HGNC:3166
Homologene: 1072
Dsp
Name: desmoplakin
Synonyms: rul, 2300002E22Rik, DP, 5730453H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 109620
VEGA: 13
HGNC: HGNC:3052
Homologene: 37922
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: Dat1, DAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 13162
VEGA: 13
Homologene: 55547
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: NCAM-1, CD56, E-NCAM, NCAM-180, NCAM-140, NCAM-120, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17967
VEGA: 9
HGNC: HGNC:7656
Homologene: 40754
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218236
VEGA: 13
Homologene: 8752
Vegfa
Name: vascular endothelial growth factor A
Synonyms: VPF, VEGF120, VEGF188, VEGF164, VEGF-A, Vegf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22339
VEGA: 17
Homologene: 2534
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Synonyms: IGnT, 5330430K10Rik, IGnTA, IGnTB, IGnTC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp15a, 1700087N07Rik, mRRp10, mRRp0, p180, 5730465C04Rik, ES/130, mRRp5.4, mRRp2, mRRp15b, mRRp47, mRRp41, mRRp16.8, mRRp1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 81910
VEGA: 2
Homologene: 68138
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: antiporter, Nhe-1, Apnh, Nhe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20544
VEGA: 4
Homologene: 20660
Ctnnd2
Name: catenin (cadherin associated protein), delta 2
Synonyms: neurojugin, Catnd2, Nprap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Ttn
Name: titin
Synonyms: D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, mdm, 1100001C23Rik, shru, connectin, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
VEGA: 2
Homologene: 130650
Olfr575
Name: olfactory receptor 575
Synonyms: GA_x6K02T2PBJ9-5666843-5665908, MOR8-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259118
VEGA: 7
Homologene: 122786
Vnn1
Name: vanin 1
Synonyms: pantetheinase, V-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22361
VEGA: 10
Homologene: 32130
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 211936
Homologene: 52235
Jmjd8
Name: jumonji domain containing 8
Synonyms: 2610003J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 72106
VEGA: 17
Homologene: 12441
Unc13a
Name: unc-13 homolog A
Synonyms: 2410078G03Rik, Munc13-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382018
VEGA: 8
Homologene: 11279
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74424
VEGA: 7
Homologene: 11713
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243881
Homologene: 117483
Rccd1
Name: RCC1 domain containing 1
Synonyms: E430018M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269955
VEGA: 7
Homologene: 16782
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 57748
VEGA: 13
Homologene: 10955
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: NaN, NaT, NSS2, SNS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 24046
VEGA: 9
Homologene: 8041
Dzank1
Name: double zinc ribbon and ankyrin repeat domains 1
Synonyms: 2810039F03Rik, 6330439K17Rik, Ankrd64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241688
VEGA: 2
Homologene: 10037
Klhl31
Name: kelch-like 31
Synonyms: D930047P17Rik, 9830147P19Rik, Kbtbd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244923
VEGA: 9
Homologene: 27819
Gm6578
Name: predicted gene 6578
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 625347
Zfp365
Name: zinc finger protein 365
Synonyms: Su48, DBZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216049
VEGA: 10
Homologene: 8975
Ccl25
Name: chemokine (C-C motif) ligand 25
Synonyms: CKb15, Scya25, TECK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20300
VEGA: 8
Homologene: 4109
Vmn1r119
Name: vomeronasal 1 receptor 119
Synonyms: LOC384696, Gm1447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384696
VEGA: 7
Homologene: 104166
Psmd6
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Synonyms: 2400006A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66413
VEGA: 14
HGNC: HGNC:9564
Homologene: 7157
Mogs
Name: mannosyl-oligosaccharide glucosidase
Synonyms: 1810017N02Rik, Gcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 57377
VEGA: 6
Homologene: 4593
Gimap4
Name: GTPase, IMAP family member 4
Synonyms: E430007K16Rik, Ian1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 107526
VEGA: 6
Homologene: 75084
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: Oit2, EF-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18301
VEGA: 7
HGNC: HGNC:4029
Homologene: 7458
Ndufs8
Name: NADH:ubiquinone oxidoreductase core subunit S8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225887
VEGA: 19
HGNC: HGNC:7715
Homologene: 1867
Pls3
Name: plastin 3 (T-isoform)
Synonyms: T-fimbrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 102866
VEGA: X
HGNC: HGNC:9091
Homologene: 128200
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 76,754,824 bp
  • A to T, chromosome 2 at 104,985,010 bp
  • T to C, chromosome 2 at 143,957,573 bp
  • T to C, chromosome 2 at 143,963,108 bp
  • T to C, chromosome 2 at 144,491,845 bp
  • A to G, chromosome 4 at 58,487,115 bp
  • T to C, chromosome 4 at 133,412,089 bp
  • G to A, chromosome 6 at 12,100,188 bp
  • A to G, chromosome 6 at 48,690,577 bp
  • T to C, chromosome 6 at 83,116,067 bp
  • T to A, chromosome 7 at 21,011,861 bp
  • C to T, chromosome 7 at 26,666,027 bp
  • C to A, chromosome 7 at 31,035,386 bp
  • T to C, chromosome 7 at 80,320,165 bp
  • C to A, chromosome 7 at 99,164,705 bp
  • T to A, chromosome 7 at 102,955,085 bp
  • A to G, chromosome 7 at 118,674,663 bp
  • T to A, chromosome 8 at 4,349,829 bp
  • T to C, chromosome 8 at 71,666,667 bp
  • C to A, chromosome 9 at 49,506,959 bp
  • T to C, chromosome 9 at 77,655,839 bp
  • T to C, chromosome 9 at 119,754,362 bp
  • A to T, chromosome 10 at 23,898,512 bp
  • A to T, chromosome 10 at 67,897,601 bp
  • T to A, chromosome 11 at 78,929,776 bp
  • A to T, chromosome 13 at 38,185,231 bp
  • T to C, chromosome 13 at 40,888,190 bp
  • A to T, chromosome 13 at 48,889,258 bp
  • A to G, chromosome 13 at 73,544,834 bp
  • G to C, chromosome 13 at 93,498,882 bp
  • C to A, chromosome 13 at 93,499,273 bp
  • T to C, chromosome 14 at 14,112,297 bp
  • G to T, chromosome 14 at 64,779,356 bp
  • C to A, chromosome 15 at 30,905,820 bp
  • T to A, chromosome 15 at 96,371,756 bp
  • A to G, chromosome 17 at 25,829,813 bp
  • A to G, chromosome 17 at 46,031,466 bp
  • A to G, chromosome 19 at 3,591,778 bp
  • A to T, chromosome 19 at 3,911,014 bp
  • A to T, chromosome X at 75,802,532 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4279 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041079-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.