Strain Name:
C57BL/6J-MtgxR4279Btlr/Mmmh
Stock Number:
041079-MU
Citation ID:
RRID:MMRRC_041079-MU
Other Names:
R4279 (G1), C57BL/6J-MtgxR4279Btlr
Major Collection:

Strain Information

Nos2
Name: nitric oxide synthase 2, inducible
Synonyms: iNOS, Nos-2, NOS-II, Nos2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18126
HGNC: HGNC:7873
Homologene: 55473
Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67800
Homologene: 23580
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Kif13b
Name: kinesin family member 13B
Synonyms: GAKIN, N-3 kinesin, C130021D12Rik, 5330429L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: vzg-1, LPA1, Kdt2, Gpcr26, Edg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14745
HGNC: HGNC:3166
Homologene: 1072
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: DAT, Dat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: CD56, NCAM-1, NCAM-120, NCAM-140, NCAM-180, E-NCAM, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Vegfa
Name: vascular endothelial growth factor A
Synonyms: VPF, VEGF-A, VEGF120, Vegf, VEGF188, VEGF164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22339
Homologene: 2534
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Synonyms: IGnTC, IGnTB, IGnTA, 5330430K10Rik, IGnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 5730465C04Rik, 1700087N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 81910
Homologene: 68138
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: antiporter, Apnh, Nhe1, Nhe-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20544
Homologene: 20660
Ctnnd2
Name: catenin (cadherin associated protein), delta 2
Synonyms: Nprap, Catnd2, neurojugin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Or51a6
Name: olfactory receptor family 51 subfamily A member 6
Synonyms: GA_x6K02T2PBJ9-5666843-5665908, MOR8-1, Olfr575
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259118
Homologene: 122786
Vnn1
Name: vanin 1
Synonyms: pantetheinase, V-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22361
Homologene: 32130
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211936
Homologene: 52235
Jmjd8
Name: jumonji domain containing 8
Synonyms: 2610003J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72106
Homologene: 12441
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382018
Homologene: 11279
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243881
HGNC: HGNC:2615
Homologene: 117483
Rccd1
Name: RCC1 domain containing 1
Synonyms: E430018M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269955
Homologene: 16782
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Dzank1
Name: double zinc ribbon and ankyrin repeat domains 1
Synonyms: 2810039F03Rik, Ankrd64, 6330439K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241688
Homologene: 10037
Klhl31
Name: kelch-like 31
Synonyms: D930047P17Rik, Kbtbd1, 9830147P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244923
Homologene: 27819
Gm6578
Name: predicted gene 6578
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 625347
Zfp365
Name: zinc finger protein 365
Synonyms: Su48, DBZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216049
Homologene: 8975
Ccl25
Name: chemokine (C-C motif) ligand 25
Synonyms: TECK, Scya25, CKb15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20300
Homologene: 4109
Vmn1r119
Name: vomeronasal 1 receptor 119
Synonyms: LOC384696, Gm1447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384696
Homologene: 104166
Psmd6
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Synonyms: 2400006A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66413
HGNC: HGNC:9564
Homologene: 7157
Mogs
Name: mannosyl-oligosaccharide glucosidase
Synonyms: 1810017N02Rik, Gcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 57377
Homologene: 4593
Gimap4
Name: GTPase, IMAP family member 4
Synonyms: E430007K16Rik, Ian1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107526
Homologene: 75084
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: EF-8, Oit2, dysadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18301
HGNC: HGNC:4029
Homologene: 7458
Ndufs8
Name: NADH:ubiquinone oxidoreductase core subunit S8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225887
VEGA: 19
HGNC: HGNC:7715
Homologene: 1867
Pls3
Name: plastin 3 (T-isoform)
Synonyms: T-fimbrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 102866
HGNC: HGNC:9091
Homologene: 128200
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 76,754,824 bp
  • A to T, chromosome 2 at 104,985,010 bp
  • T to C, chromosome 2 at 143,957,573 bp
  • T to C, chromosome 2 at 143,963,108 bp
  • T to C, chromosome 2 at 144,491,845 bp
  • A to G, chromosome 4 at 58,487,115 bp
  • T to C, chromosome 4 at 133,412,089 bp
  • G to A, chromosome 6 at 12,100,188 bp
  • A to G, chromosome 6 at 48,690,577 bp
  • T to C, chromosome 6 at 83,116,067 bp
  • T to A, chromosome 7 at 21,011,861 bp
  • C to T, chromosome 7 at 26,666,027 bp
  • C to A, chromosome 7 at 31,035,386 bp
  • T to C, chromosome 7 at 80,320,165 bp
  • C to A, chromosome 7 at 99,164,705 bp
  • T to A, chromosome 7 at 102,955,085 bp
  • A to G, chromosome 7 at 118,674,663 bp
  • T to A, chromosome 8 at 4,349,829 bp
  • T to C, chromosome 8 at 71,666,667 bp
  • C to A, chromosome 9 at 49,506,959 bp
  • T to C, chromosome 9 at 77,655,839 bp
  • T to C, chromosome 9 at 119,754,362 bp
  • A to T, chromosome 10 at 23,898,512 bp
  • A to T, chromosome 10 at 67,897,601 bp
  • T to A, chromosome 11 at 78,929,776 bp
  • A to T, chromosome 13 at 38,185,231 bp
  • T to C, chromosome 13 at 40,888,190 bp
  • A to T, chromosome 13 at 48,889,258 bp
  • A to G, chromosome 13 at 73,544,834 bp
  • G to C, chromosome 13 at 93,498,882 bp
  • C to A, chromosome 13 at 93,499,273 bp
  • T to C, chromosome 14 at 14,112,297 bp
  • G to T, chromosome 14 at 64,779,356 bp
  • C to A, chromosome 15 at 30,905,820 bp
  • T to A, chromosome 15 at 96,371,756 bp
  • A to G, chromosome 17 at 25,829,813 bp
  • A to G, chromosome 17 at 46,031,466 bp
  • A to G, chromosome 19 at 3,591,778 bp
  • A to T, chromosome 19 at 3,911,014 bp
  • A to T, chromosome X at 75,802,532 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4279 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041079-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.