Strain Name:
C57BL/6J-MtgxR4342Btlr/Mmmh
Stock Number:
041100-MU
Citation ID:
RRID:MMRRC_041100-MU
Other Names:
R4342 (G1), C57BL/6J-MtgxR4342Btlr
Major Collection:

Gene Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72895
Homologene: 12485
Pkp4
Name: plakophilin 4
Synonyms: p0071, Armrp, 5031422I09Rik, 9430019K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100710
Homologene: 41001
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 245945
Homologene: 36932
Rbm6
Name: RNA binding motif protein 6
Synonyms: NY-LU-12, g16, Def-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19654
HGNC: HGNC:9903
Homologene: 31336
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328329
Homologene: 42094
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: PARP, sPARP-1, Adprp, parp-1, 5830444G22Rik, Adprt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, 2610511G22Rik, 6030460N08Rik, TRIP230, GMAP-210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 109181
Homologene: 20897
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194401
Homologene: 85288
Dhx8
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 8
Synonyms: mDEAH6, RNA helicase, Ddx8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Ntm
Name: neurotrimin
Synonyms: B230210G24Rik, 6230410L23Rik, Hnt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235106
Homologene: 41139
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Arhgap44
Name: Rho GTPase activating protein 44
Synonyms: AU040829
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216831
Homologene: 65284
Ccdc174
Name: coiled-coil domain containing 174
Synonyms: C130022K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232236
Homologene: 9523
Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
Synonyms: REV-ERBalpha, A530070C09Rik, rev-erbA(alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217166
HGNC: HGNC:7962
Homologene: 23324
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229474
Homologene: 18920
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: ZFYVE5, 5830461L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 30938
Homologene: 22925
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329502
Homologene: 65339
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Hoxc11
Name: homeobox C11
Synonyms: Hox-3.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109663
HGNC: HGNC:5123
Homologene: 130362
Fam71b
Name: family with sequence similarity 71, member B
Synonyms: OTTMUSG00000005491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432552
Homologene: 51067
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Ttf1
Name: transcription termination factor, RNA polymerase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22130
Homologene: 137223
Fscn1
Name: fascin actin-bundling protein 1
Synonyms: Fan1, fascin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14086
Homologene: 48164
Epas1
Name: endothelial PAS domain protein 1
Synonyms: MOP2, HIF-2alpha, Hif like protein, hypoxia inducible transcription factor 2alpha, HLF, HRF, bHLHe73, HIF2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Nhsl1
Name: NHS-like 1
Synonyms: A630035H13Rik, D10Bwg0940e, 5730409E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215819
Homologene: 27834
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: RalGDS, Rgds, Gnds
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Fbxl2
Name: F-box and leucine-rich repeat protein 2
Synonyms: 2810423A21Rik, Fbl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72179
Homologene: 135814
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269116
Homologene: 24945
Nek4
Name: NIMA (never in mitosis gene a)-related expressed kinase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 23955
VEGA: 14
Homologene: 2376
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Sgf29
Name: SAGA complex associated factor 29
Synonyms: 1700023O11Rik, Ccdc101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75565
Homologene: 12607
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 3110007G05Rik, 1700084G18Rik, 2310039H16Rik, B130050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213027
Homologene: 134635
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22238
Homologene: 137225
Ajm1
Name: apical junction component 1
Synonyms: LOC381353, Gm996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381353
Homologene: 19943
Cth
Name: cystathionase (cystathionine gamma-lyase)
Synonyms: 0610010I13Rik, CSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107869
HGNC: HGNC:2501
Homologene: 1432
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms: lysyl hydroxylase 3, LH3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26433
HGNC: HGNC:9083
Homologene: 843
Mcts2
Name: malignant T cell amplified sequence 2
Synonyms: 2400002F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66405
Homologene: 105738
Vmn1r14
Name: vomeronasal 1 receptor 14
Synonyms: V1rc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113864
Homologene: 74373
Dnajc22
Name: DnaJ heat shock protein family (Hsp40) member C22
Synonyms: 2810451A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72778
Homologene: 11777
Cers4
Name: ceramide synthase 4
Synonyms: 2900019C14Rik, Trh1, CerS4, Lass4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67260
Homologene: 11582
Slc22a12
Name: solute carrier family 22 (organic anion/cation transporter), member 12
Synonyms: Rst, URAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20521
Homologene: 56442
Zfp131
Name: zinc finger protein 131
Synonyms: Znf131, 2610109I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72465
VEGA: 13
Homologene: 12464
Wdyhv1
Name: WDYHV motif containing 1
Synonyms: 2410187C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76773
VEGA: 15
Homologene: 9968
Cldn23
Name: claudin 23
Synonyms: 2310014B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71908
Homologene: 12421
Olfr576
Name: olfactory receptor 576
Synonyms: GA_x6K02T2PBJ9-5676385-5677371, MOR8-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258248
Homologene: 45856
Stambpl1
Name: STAM binding protein like 1
Synonyms: 8230401J17Rik, 1700095N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76630
Homologene: 23253
Gm5878
Name: predicted gene 5878
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545861
Scp2d1
Name: SCP2 sterol-binding domain containing 1
Synonyms: 1700010M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66328
Homologene: 11947
Ighv10-3
Name: immunoglobulin heavy variable V10-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380809
Gm6901
Name: predicted gene 6901
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,058,617 bp
  • A to G, chromosome 1 at 132,631,705 bp
  • G to T, chromosome 1 at 180,587,329 bp
  • A to G, chromosome 2 at 25,579,108 bp
  • T to C, chromosome 2 at 28,552,095 bp
  • C to T, chromosome 2 at 29,065,476 bp
  • A to T, chromosome 2 at 59,350,608 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to C, chromosome 2 at 120,186,446 bp
  • T to C, chromosome 2 at 144,824,167 bp
  • G to A, chromosome 2 at 152,687,664 bp
  • C to A, chromosome 3 at 84,444,826 bp
  • T to A, chromosome 3 at 157,924,976 bp
  • A to C, chromosome 5 at 43,869,089 bp
  • G to A, chromosome 5 at 66,026,623 bp
  • A to T, chromosome 5 at 87,139,723 bp
  • G to C, chromosome 5 at 136,988,146 bp
  • T to C, chromosome 5 at 142,972,021 bp
  • A to G, chromosome 5 at 150,800,854 bp
  • T to A, chromosome 6 at 57,233,823 bp
  • G to A, chromosome 6 at 85,125,651 bp
  • T to A, chromosome 6 at 91,885,356 bp
  • AT to ATT, chromosome 6 at 113,111,320 bp
  • C to A, chromosome 6 at 120,934,838 bp
  • A to G, chromosome 7 at 102,966,024 bp
  • G to A, chromosome 7 at 126,671,777 bp
  • A to C, chromosome 8 at 4,183,492 bp
  • T to C, chromosome 8 at 4,521,223 bp
  • A to G, chromosome 8 at 35,825,498 bp
  • T to C, chromosome 9 at 29,109,431 bp
  • A to T, chromosome 9 at 107,847,247 bp
  • A to G, chromosome 9 at 110,631,793 bp
  • A to T, chromosome 9 at 113,985,306 bp
  • T to C, chromosome 10 at 18,526,689 bp
  • T to C, chromosome 10 at 83,504,131 bp
  • A to G, chromosome 11 at 46,407,216 bp
  • G to A, chromosome 11 at 65,012,061 bp
  • T to G, chromosome 11 at 98,771,814 bp
  • T to C, chromosome 11 at 101,733,109 bp
  • T to C, chromosome 11 at 106,567,006 bp
  • A to T, chromosome 11 at 115,988,729 bp
  • T to C, chromosome 12 at 86,260,679 bp
  • A to T, chromosome 12 at 101,884,316 bp
  • A to T, chromosome 12 at 114,523,504 bp
  • C to T, chromosome 13 at 49,273,709 bp
  • T to C, chromosome 13 at 65,559,688 bp
  • A to G, chromosome 13 at 102,774,248 bp
  • C to T, chromosome 13 at 119,776,018 bp
  • T to C, chromosome 14 at 30,953,906 bp
  • G to A, chromosome 15 at 45,114,444 bp
  • T to C, chromosome 15 at 58,152,714 bp
  • T to A, chromosome 15 at 99,104,464 bp
  • C to T, chromosome 15 at 102,954,671 bp
  • A to G, chromosome 16 at 9,653,589 bp
  • C to T, chromosome 17 at 12,709,511 bp
  • T to C, chromosome 17 at 45,516,495 bp
  • G to A, chromosome 17 at 86,823,800 bp
  • T to A, chromosome 18 at 10,544,561 bp
  • A to T, chromosome 18 at 58,942,500 bp
  • A to G, chromosome 19 at 6,541,099 bp
  • T to C, chromosome 19 at 9,012,083 bp
  • A to G, chromosome 19 at 34,234,046 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041100-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.