Strain Name:
C57BL/6J-MtgxR4355Btlr/Mmmh
Stock Number:
041108-MU
Citation ID:
RRID:MMRRC_041108-MU
Other Names:
R4355 (G1), C57BL/6J-MtgxR4355Btlr
Major Collection:

Strain Information

Aldh7a1
Name: aldehyde dehydrogenase family 7, member A1
Synonyms: Atq1, D18Wsu181e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 110695
HGNC: HGNC:877
Homologene: 913
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12695
Homologene: 72199
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99633
Homologene: 22712
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: SPAG13, CS-1, CS1, KRAP, Ssfa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70599
Homologene: 4912
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Ddx47
Name: DEAD box helicase 47
Synonyms: 4930588A18Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67755
Homologene: 6092
Nf2
Name: neurofibromin 2
Synonyms: schwannomin, merlin, moesin-ezrin-radixin-like protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Arntl
Name: aryl hydrocarbon receptor nuclear translocator-like
Synonyms: Arnt3, MOP3, Bmal1, bHLHe5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11865
HGNC: HGNC:701
Homologene: 910
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233064
Homologene: 15927
Utp15
Name: UTP15 small subunit processome component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105372
VEGA: 13
Homologene: 6629
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: Nix, D14Ertd719e, Nip3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, castor, Cst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69743
Homologene: 9824
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Gosr1
Name: golgi SNAP receptor complex member 1
Synonyms: Cis-Golgi SNARE, GS28, GOS-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53334
HGNC: HGNC:4430
Homologene: 37977
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Obi1
Name: ORC ubiquitin ligase 1
Synonyms: 2810449K13Rik, 2610206B13Rik, Rnf219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72486
VEGA: 14
Homologene: 11578
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
G2e3
Name: G2/M-phase specific E3 ubiquitin ligase
Synonyms: D930034K21Rik, 6030408C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217558
Homologene: 32362
Prkg1
Name: protein kinase, cGMP-dependent, type I
Synonyms: Prkgr1b, Prkg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19091
HGNC: HGNC:9414
Homologene: 55964
F7
Name: coagulation factor VII
Synonyms: FVII, Cf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14068
HGNC: HGNC:3544
Homologene: 7710
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232854
Homologene: 119890
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms: eIF-2 alpha, Pkr, dsRNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Prkr, Tik, eIF-2 alpha, 4732414G15Rik, 2310047A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19106
HGNC: HGNC:9437
Homologene: 48134
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, MOR106-14, Olfr265, Olfr743-ps1, Olfr264, Olfr743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219019
Homologene: 74163
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist1, Egfr-rs, Dist
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13650
Homologene: 32085
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: Mtsh2, Sdccag33l, 2900073F20Rik, Zfp218, teashirt2, Tsh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228911
Homologene: 35258
Bcl3
Name: B cell leukemia/lymphoma 3
Synonyms: Bcl-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12051
HGNC: HGNC:998
Homologene: 81738
Kbtbd11
Name: kelch repeat and BTB (POZ) domain containing 11
Synonyms: 4930465M17Rik, 2900016B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74901
Homologene: 28701
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Adam26a
Name: a disintegrin and metallopeptidase domain 26A (testase 3)
Synonyms: Dtgn4, Adam26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13525
Homologene: 128363
Usp43
Name: ubiquitin specific peptidase 43
Synonyms: C630032K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216835
Homologene: 129879
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC239731, LOC385766, RIM-BP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239731
Homologene: 77940
Ufsp2
Name: UFM1-specific peptidase 2
Synonyms: 1810047C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 192169
Homologene: 10151
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22238
Homologene: 137225
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Itgb5
Name: integrin beta 5
Synonyms: [b]5B, [b]5A, [b]-5, beta-5, beta5, [b]5, ESTM23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16419
HGNC: HGNC:6160
Homologene: 20511
Rsph6a
Name: radial spoke head 6 homolog A (Chlamydomonas)
Synonyms: RSP4, Rshl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83434
Homologene: 36476
Or12k8
Name: olfactory receptor family 12 subfamily K member 8
Synonyms: GA_x6K02T2NLDC-33777519-33776551, MOR159-3, Olfr361
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258365
Homologene: 27142
Rps4l
Name: ribosomal protein S4-like
Synonyms: 1110033J19Rik, Rps4y2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66184
Ston1
Name: stonin 1
Synonyms: 4921524J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77057
Homologene: 122152
Mrgprb4
Name: MAS-related GPR, member B4
Synonyms: MrgB4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233230
Homologene: 115575
Tas2r109
Name: taste receptor, type 2, member 109
Synonyms: T2R09, Tas2r9, mGR09, mt2r62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387343
Homologene: 87292
Nmnat3
Name: nicotinamide nucleotide adenylyltransferase 3
Synonyms: PNAT3, 4933408N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74080
Homologene: 39772
Klrc3
Name: killer cell lectin-like receptor subfamily C, member 3
Synonyms: NKG2E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58179
Homologene: 130643
Ighv3-4
Name: immunoglobulin heavy variable V3-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629833
Clca4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Kcnmb4os2
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2
Synonyms: 4933400F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100504412
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 2 at 37,084,930 bp
  • A to G, chromosome 2 at 79,641,998 bp
  • A to G, chromosome 2 at 155,991,525 bp
  • G to A, chromosome 2 at 169,884,938 bp
  • A to G, chromosome 2 at 180,606,478 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to T, chromosome 3 at 144,825,458 bp
  • A to T, chromosome 3 at 148,839,152 bp
  • T to A, chromosome 4 at 58,138,695 bp
  • T to G, chromosome 4 at 98,650,454 bp
  • T to A, chromosome 4 at 123,475,091 bp
  • C to T, chromosome 4 at 137,529,418 bp
  • T to C, chromosome 4 at 148,952,335 bp
  • C to A, chromosome 5 at 87,139,763 bp
  • C to A, chromosome 5 at 96,700,242 bp
  • T to C, chromosome 6 at 129,639,162 bp
  • A to T, chromosome 6 at 132,980,181 bp
  • T to C, chromosome 6 at 135,021,505 bp
  • T to C, chromosome 6 at 148,355,098 bp
  • T to A, chromosome 7 at 7,172,162 bp
  • T to A, chromosome 7 at 19,067,078 bp
  • G to T, chromosome 7 at 19,811,580 bp
  • A to C, chromosome 7 at 30,242,248 bp
  • C to T, chromosome 7 at 48,198,701 bp
  • C to T, chromosome 7 at 50,120,599 bp
  • A to G, chromosome 7 at 101,827,314 bp
  • A to G, chromosome 7 at 113,303,406 bp
  • A to G, chromosome 7 at 114,416,287 bp
  • A to G, chromosome 8 at 13,034,774 bp
  • C to A, chromosome 8 at 15,028,578 bp
  • T to G, chromosome 8 at 43,570,185 bp
  • T to A, chromosome 8 at 45,985,465 bp
  • C to T, chromosome 9 at 98,410,152 bp
  • A to G, chromosome 10 at 21,152,617 bp
  • A to G, chromosome 10 at 116,473,284 bp
  • G to A, chromosome 11 at 4,780,613 bp
  • C to T, chromosome 11 at 32,216,236 bp
  • A to G, chromosome 11 at 67,891,464 bp
  • T to C, chromosome 11 at 76,754,782 bp
  • T to A, chromosome 12 at 51,365,337 bp
  • C to T, chromosome 12 at 110,632,899 bp
  • T to C, chromosome 12 at 114,253,640 bp
  • T to C, chromosome 13 at 11,649,812 bp
  • A to G, chromosome 13 at 77,106,090 bp
  • A to T, chromosome 13 at 98,259,247 bp
  • T to C, chromosome 14 at 50,533,759 bp
  • A to G, chromosome 14 at 50,959,625 bp
  • T to C, chromosome 14 at 66,989,486 bp
  • A to G, chromosome 14 at 104,479,257 bp
  • T to C, chromosome 15 at 74,543,662 bp
  • C to T, chromosome 15 at 90,970,833 bp
  • A to G, chromosome 16 at 17,209,692 bp
  • T to A, chromosome 16 at 33,844,997 bp
  • T to A, chromosome 17 at 78,858,534 bp
  • T to G, chromosome 17 at 88,637,008 bp
  • A to T, chromosome 18 at 56,548,494 bp
  • A to T, chromosome 18 at 67,626,640 bp
  • A to G, chromosome 19 at 30,569,229 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4355 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041108-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.