Strain Name:
C57BL/6J-MtgxR4360Btlr/Mmmh
Stock Number:
041111-MU
Citation ID:
RRID:MMRRC_041111-MU
Other Names:
R4360 (G1), C57BL/6J-MtgxR4360Btlr
Major Collection:

Gene Information

Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74996
Homologene: 9929
Hspa4
Name: heat shock protein 4
Synonyms: Hsp110, 70kDa, Hsp70RY, APG-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Stk4
Name: serine/threonine kinase 4
Synonyms: Ysk3, Kas-2, sterile 20-like kinase 1, Mst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 58231
Homologene: 55965
Atg14
Name: autophagy related 14
Synonyms: Barkor, D14Ertd114e, D14Ertd436e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 100504663
VEGA: 14
Homologene: 45423
Zc3h14
Name: zinc finger CCCH type containing 14
Synonyms: 1700016A15Rik, 2700069A02Rik, 1010001P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 75553
VEGA: 12
Homologene: 32605
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Zfp26
Name: zinc finger protein 26
Synonyms: mkr-3, Zfp70, Zfp81-rs1, 5033428C05Rik, Zfp-26, KRAB15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22688
Homologene: 52318
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: Adprtl1, VPARP, C030027K23Rik, E230037B21Rik, VAULT3, PH5P, p193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Pabpc1
Name: poly(A) binding protein, cytoplasmic 1
Synonyms: Pabpl1, Pabp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18458
HGNC: HGNC:8554
Homologene: 37638
Slc18a3
Name: solute carrier family 18 (vesicular monoamine), member 3
Synonyms: VAT, VAChT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 20508
Homologene: 11022
Tnc
Name: tenascin C
Synonyms: hexabrachion, Hxb, cytotactin, tenascin-C, C130033P17Rik, TN-C, TN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: Gpr125, 3830613O22Rik, Tem5-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70693
Homologene: 19235
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71389
Homologene: 32772
Scpep1
Name: serine carboxypeptidase 1
Synonyms: 2410018F01Rik, Risc, 4833411K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74617
Homologene: 41443
Stard3nl
Name: STARD3 N-terminal like
Synonyms: 0610035N01Rik, 6530409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76205
Homologene: 11501
G2e3
Name: G2/M-phase specific E3 ubiquitin ligase
Synonyms: 6030408C04Rik, D930034K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217558
Homologene: 32362
Sp8
Name: trans-acting transcription factor 8
Synonyms: D930049B17Rik, mBtd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320145
VEGA: 12
Homologene: 18548
Pkp2
Name: plakophilin 2
Synonyms: Pkp2l, 1200012P04Rik, 1200008D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22068
VEGA: 9
Homologene: 37944
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227334
Homologene: 32400
Fmo2
Name: flavin containing monooxygenase 2
Synonyms: 2310008D08Rik, 2310042I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 55990
HGNC: HGNC:3770
Homologene: 86882
Frmd4a
Name: FERM domain containing 4A
Synonyms: 2700017I06Rik, C230040M21Rik, Gm13190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 209630
Homologene: 9971
Olfr679
Name: olfactory receptor 679
Synonyms: MOR40-2, GA_x6K02T2PBJ9-7714499-7715446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259046
Homologene: 81538
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Zfp811
Name: zinc finger protein 811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240063
Csn1s2a
Name: casein alpha s2-like A
Synonyms: Csng, Csn1s2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12993
Homologene: 7284
Fah
Name: fumarylacetoacetate hydrolase
Synonyms: swst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14085
HGNC: HGNC:3579
Homologene: 110
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, Hfhbf1, Bf1, BF-1, 2900064B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Olfr830
Name: olfactory receptor 830
Synonyms: GA_x6K02T2PVTD-12618399-12619337, MOR152-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258559
Homologene: 79360
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20392
Homologene: 31205
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74682
Homologene: 10814
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 231999
Homologene: 32284
Hspa14
Name: heat shock protein 14
Synonyms: NST-1, Hsp70-4, HSP70L1, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 50497
Homologene: 74307
Pramef25
Name: PRAME family member 25
Synonyms: Gm13109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329984
Homologene: 83161
Olfr539
Name: olfactory receptor 539
Synonyms: MOR253-4, GA_x6K02T2PBJ9-42813436-42814368
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258963
Homologene: 79393
Islr
Name: immunoglobulin superfamily containing leucine-rich repeat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 26968
VEGA: 9
HGNC: HGNC:6133
Homologene: 4050
Tbcb
Name: tubulin folding cofactor B
Synonyms: 2410007D12Rik, Ckap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66411
HGNC: HGNC:1989
Homologene: 981
Gm1758
Name: predicted gene 1758
Synonyms: LOC385737
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
Trem3
Name: triggering receptor expressed on myeloid cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 58218
VEGA: 17
Homologene: 87012
BC023105
Name: cDNA sequence BC023105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 667597
VEGA: 18
Gm21972
Name: predicted gene 21972
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Gm829
Name: predicted gene 829
Synonyms: LOC329839
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329839
Gm3436
Name: predicted pseudogene 3436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100041622
VEGA: 9
RP24-278K24.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
Gm7204
Name: predicted pseudogene 7204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 637273
VEGA: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • A to G, chromosome 1 at 86,133,737 bp
  • C to T, chromosome 1 at 87,952,361 bp
  • T to C, chromosome 1 at 162,882,014 bp
  • A to G, chromosome 2 at 3,502,523 bp
  • A to T, chromosome 2 at 4,601,241 bp
  • A to G, chromosome 2 at 160,949,856 bp
  • A to G, chromosome 2 at 164,088,959 bp
  • T to C, chromosome 4 at 45,718,819 bp
  • G to T, chromosome 4 at 64,016,924 bp
  • A to G, chromosome 4 at 143,950,863 bp
  • T to C, chromosome 5 at 49,990,210 bp
  • G to T, chromosome 5 at 87,781,841 bp
  • A to G, chromosome 5 at 125,028,972 bp
  • C to T, chromosome 6 at 4,707,265 bp
  • T to C, chromosome 6 at 54,622,186 bp
  • T to C, chromosome 7 at 30,227,035 bp
  • G to A, chromosome 7 at 84,589,648 bp
  • A to C, chromosome 7 at 105,086,253 bp
  • G to T, chromosome 7 at 112,054,932 bp
  • T to C, chromosome 7 at 140,667,817 bp
  • A to G, chromosome 9 at 8,610,266 bp
  • G to A, chromosome 9 at 18,875,717 bp
  • T to C, chromosome 9 at 20,438,573 bp
  • T to A, chromosome 9 at 58,157,604 bp
  • T to C, chromosome 9 at 70,852,582 bp
  • T to C, chromosome 11 at 53,265,092 bp
  • A to G, chromosome 11 at 88,930,244 bp
  • T to C, chromosome 12 at 8,974,149 bp
  • CCAGCAGCAGCAGCAGCAGC to CCAGCAGCAGCAGCAGC, chromosome 12 at 49,384,692 bp
  • T to A, chromosome 12 at 51,363,414 bp
  • A to G, chromosome 12 at 98,780,197 bp
  • A to G, chromosome 12 at 118,848,665 bp
  • G to A, chromosome 13 at 19,370,484 bp
  • A to G, chromosome 14 at 32,463,925 bp
  • C to G, chromosome 14 at 47,568,370 bp
  • A to G, chromosome 14 at 56,629,204 bp
  • T to C, chromosome 14 at 66,938,401 bp
  • C to T, chromosome 15 at 36,605,465 bp
  • A to T, chromosome 16 at 14,506,351 bp
  • A to G, chromosome 16 at 16,268,682 bp
  • A to G, chromosome 16 at 37,060,339 bp
  • T to C, chromosome 16 at 48,218,833 bp
  • T to C, chromosome 17 at 32,798,458 bp
  • T to A, chromosome 17 at 48,249,773 bp
  • G to T, chromosome 18 at 60,442,001 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4360 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041111-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.