Strain Name:
C57BL/6J-MtgxR4423Btlr/Mmmh
Stock Number:
041143-MU
Citation ID:
RRID:MMRRC_041143-MU
Other Names:
R4423 (G1), C57BL/6J-MtgxR4423Btlr
Major Collection:

Gene Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 268281
Homologene: 6489
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: C130078N17Rik, Wdt4, ANKRD4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228852
Homologene: 9194
Dst
Name: dystonin
Synonyms: A830042E19Rik, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, BPAG1, athetoid, Bpag, ah, bullous pemphigoid antigen 1, Bpag1, nmf339, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
Synonyms: 5730454C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231327
HGNC: HGNC:9238
Homologene: 68272
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: EG406236, Hsn2, 6430573H23Rik, Prkwnk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232341
Homologene: 14253
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, Gm15797, D16Ertd95e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: B3RP, Ae2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20535
Homologene: 128699
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105445
Homologene: 41026
Map4
Name: microtubule-associated protein 4
Synonyms: Mtap4, MAP 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Tut7
Name: terminal uridylyl transferase 7
Synonyms: Zcchc6, Tent3b, 6030448M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 214290
VEGA: 13
Homologene: 51941
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, N-3 kinesin, A530096N05Rik, KIF1Bp204, Kif1b alpha, Kif1b beta, KIF1Bp130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16561
Homologene: 99835
Ccdc9
Name: coiled-coil domain containing 9
Synonyms: 2600011L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243846
Homologene: 9209
Sec62
Name: SEC62 homolog (S. cerevisiae)
Synonyms: SEC62, HTP1, Tloc1, Dtrp1, 3100002M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69276
Homologene: 2449
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: 5830462N02Rik, A130086L21Rik, E6-AP ubiquitin protein ligase, Hpve6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22215
Homologene: 7988
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27103
Homologene: 40891
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: Top-2, DNA Topoisomerase II alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21973
Homologene: 830
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78893
VEGA: 9
Homologene: 41040
Arfgap1
Name: ADP-ribosylation factor GTPase activating protein 1
Synonyms: ARF1 GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228998
Homologene: 5517
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 73473
Homologene: 134421
Prkcq
Name: protein kinase C, theta
Synonyms: Pkcq, PKCtheta, PKC theta, PKC-0, A130035A12Rik, PKC-theta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Syvn1
Name: synovial apoptosis inhibitor 1, synoviolin
Synonyms: 1200010C09Rik, Hrd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 74126
Homologene: 32700
Far1
Name: fatty acyl CoA reductase 1
Synonyms: 2600011M19Rik, Mlstd2, 3732409C05Rik, 2900034E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67420
Homologene: 41718
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: Plod-2, lysyl hydroxylase 2, LH2, D530025C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 252972
Homologene: 9905
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: 9830168K16Rik, Trrp7, TRPC7, LTRPC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 28240
Homologene: 20709
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: B230373P09Rik, E030034C22Rik, Dnahc1, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Lcp2
Name: lymphocyte cytosolic protein 2
Synonyms: SLP76, SLP-76, twm, m1Khoe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16822
HGNC: HGNC:6529
Homologene: 4065
Capns2
Name: calpain, small subunit 2
Synonyms: 30K-2, 2310005G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 69543
Homologene: 57167
Olfr651
Name: olfactory receptor 651
Synonyms: MOR31-11, GA_x6K02T2PBJ9-7179540-7180481
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258809
Homologene: 64922
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269902
Homologene: 104832
Hsf5
Name: heat shock transcription factor family member 5
Synonyms: LOC327992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 327992
Homologene: 52701
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234686
Homologene: 136406
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: autophagin 1, Apg4b, 2510009N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66615
Homologene: 100868
1700017N19Rik
Name: RIKEN cDNA 1700017N19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 66605
Homologene: 45135
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: D16Ium24e, Glurbeta1, A830007B11Rik, D16Ium24, Glur-5, GluK5, Glur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Nepn
Name: nephrocan
Synonyms: Npn, 5730521E12Rik, periolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 66650
Homologene: 23549
Elp4
Name: elongator acetyltransferase complex subunit 4
Synonyms: Paxneb, A330107A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77766
HGNC: HGNC:1171
Homologene: 32433
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18080
Homologene: 40632
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: sodium glucose cotransporter 1, Sglt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20537
Homologene: 55456
Thegl
Name: theg spermatid protein like
Synonyms: 1700023E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71868
Homologene: 128474
Icosl
Name: icos ligand
Synonyms: B7h, GL50-B, B7-H2, ICOS-L, B7RP-1, LICOS, GL50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 50723
VEGA: 10
Homologene: 49412
Galnt15
Name: polypeptide N-acetylgalactosaminyltransferase 15
Synonyms: Galntl2, 4631401E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 78754
Homologene: 14286
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: polynucleotide phosphorylase, 1200003F12Rik, PNPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71701
Homologene: 12404
Olfr961
Name: olfactory receptor 961
Synonyms: GA_x6K02T2PVTD-33343617-33344561, MOR224-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258497
VEGA: 9
Homologene: 74020
Cep44
Name: centrosomal protein 44
Synonyms: 4933440G23Rik, BC088983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382010
Homologene: 12738
Elmo1
Name: engulfment and cell motility 1
Synonyms: 6330578D22Rik, C230095H21Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 140580
Homologene: 56685
Asgr2
Name: asialoglycoprotein receptor 2
Synonyms: Asgr-2, Asgr, ASGPR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11890
HGNC: HGNC:743
Homologene: 912
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Tex47
Name: testis expressed 47
Synonyms: 4921511H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70920
Homologene: 41723
A630010A05Rik
Name: RIKEN cDNA A630010A05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 545280
Fam183b
Name: family with sequence similarity 183, member B
Synonyms: 3100002J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 75429
Homologene: 28543
Arhgef9
Name: CDC42 guanine nucleotide exchange factor (GEF) 9
Synonyms: collybistin, 9630036L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 236915
Homologene: 9053
Olfr902
Name: olfactory receptor 902
Synonyms: GA_x6K02T2PVTD-32141623-32142552, MOR169-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258798
VEGA: 9
Rpl31-ps17
Name: ribosomal protein L31, pseudogene 17
Synonyms: Gm16382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 673582
B930094E09Rik
Name: RIKEN cDNA B930094E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Gm14277
Name: predicted gene 14277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 105244345
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,188,393 bp
  • T to C, chromosome 1 at 93,784,480 bp
  • T to C, chromosome 2 at 11,256,169 bp
  • T to C, chromosome 2 at 105,904,315 bp
  • T to C, chromosome 2 at 118,439,066 bp
  • A to G, chromosome 2 at 157,168,955 bp
  • C to T, chromosome 2 at 158,757,254 bp
  • C to A, chromosome 2 at 180,981,076 bp
  • T to C, chromosome 3 at 30,814,282 bp
  • A to G, chromosome 4 at 149,214,105 bp
  • G to T, chromosome 5 at 7,305,364 bp
  • G to A, chromosome 5 at 24,439,848 bp
  • T to C, chromosome 5 at 33,154,674 bp
  • A to G, chromosome 5 at 76,915,214 bp
  • T to C, chromosome 5 at 77,054,536 bp
  • T to C, chromosome 5 at 120,542,518 bp
  • T to A, chromosome 6 at 119,926,426 bp
  • T to C, chromosome 7 at 16,276,559 bp
  • T to C, chromosome 7 at 41,426,640 bp
  • T to C, chromosome 7 at 59,276,113 bp
  • T to C, chromosome 7 at 104,553,345 bp
  • T to A, chromosome 7 at 113,540,598 bp
  • G to A, chromosome 8 at 56,538,617 bp
  • T to A, chromosome 8 at 92,901,624 bp
  • T to C, chromosome 8 at 105,337,351 bp
  • A to G, chromosome 9 at 38,449,366 bp
  • A to G, chromosome 9 at 39,647,116 bp
  • T to C, chromosome 9 at 92,601,989 bp
  • C to T, chromosome 9 at 110,067,594 bp
  • T to A, chromosome 9 at 114,617,920 bp
  • T to G, chromosome 10 at 11,186,518 bp
  • T to A, chromosome 10 at 52,391,815 bp
  • T to C, chromosome 10 at 77,935,068 bp
  • C to T, chromosome 10 at 78,071,873 bp
  • C to A, chromosome 10 at 100,605,633 bp
  • A to G, chromosome 11 at 29,153,375 bp
  • G to T, chromosome 11 at 34,078,226 bp
  • A to T, chromosome 11 at 58,796,531 bp
  • G to A, chromosome 11 at 70,105,385 bp
  • T to C, chromosome 11 at 87,631,634 bp
  • A to G, chromosome 11 at 99,001,405 bp
  • T to A, chromosome 12 at 51,598,149 bp
  • C to T, chromosome 12 at 54,701,612 bp
  • T to A, chromosome 12 at 70,042,978 bp
  • C to G, chromosome 13 at 20,600,212 bp
  • T to C, chromosome 13 at 59,822,049 bp
  • C to T, chromosome 14 at 31,284,761 bp
  • A to T, chromosome 14 at 32,058,269 bp
  • A to G, chromosome 14 at 121,562,053 bp
  • A to G, chromosome 15 at 8,121,464 bp
  • A to G, chromosome 16 at 14,618,713 bp
  • A to G, chromosome 16 at 18,956,202 bp
  • A to G, chromosome 16 at 20,501,719 bp
  • T to C, chromosome 16 at 87,923,200 bp
  • T to C, chromosome 18 at 31,609,598 bp
  • T to A, chromosome 18 at 32,083,450 bp
  • C to T, chromosome 19 at 6,049,921 bp
  • T to G, chromosome X at 95,101,064 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4423 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041143-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.