Strain Name:
C57BL/6J-MtgxR4423Btlr/Mmmh
Stock Number:
041143-MU
Citation ID:
RRID:MMRRC_041143-MU
Other Names:
R4423 (G1), C57BL/6J-MtgxR4423Btlr
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
Synonyms: 5730454C12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231327
HGNC: HGNC:9238
Homologene: 68272
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, D16Ertd95e, Gm15797
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: B3RP, Ae2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20535
Homologene: 128699
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Tut7
Name: terminal uridylyl transferase 7
Synonyms: 6030448M23Rik, Tent3b, Zcchc6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ccdc9
Name: coiled-coil domain containing 9
Synonyms: 2600011L02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243846
Homologene: 9209
Sec62
Name: SEC62 homolog, preprotein translocation
Synonyms: HTP1, Dtrp1, SEC62, 3100002M17Rik, Tloc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69276
Homologene: 2449
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, E6-AP ubiquitin protein ligase, A130086L21Rik, 5830462N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21973
Homologene: 830
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Arfgap1
Name: ADP-ribosylation factor GTPase activating protein 1
Synonyms: ARF1 GAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228998
Homologene: 5517
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73473
Homologene: 134421
Prkcq
Name: protein kinase C, theta
Synonyms: PKC-0, Pkcq, A130035A12Rik, PKC-theta, PKC theta, PKCtheta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Coch
Name: cochlin
Synonyms: Coch-5B2, D12H14S564E
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Syvn1
Name: synovial apoptosis inhibitor 1, synoviolin
Synonyms: Hrd1, 1200010C09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74126
Homologene: 32700
Far1
Name: fatty acyl CoA reductase 1
Synonyms: 2600011M19Rik, 3732409C05Rik, Mlstd2, 2900034E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67420
Homologene: 41718
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: lysyl hydroxylase 2, LH2, Plod-2, D530025C14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 252972
Homologene: 9905
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: Trrp7, LTRPC2, TRPC7, 9830168K16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Lcp2
Name: lymphocyte cytosolic protein 2
Synonyms: SLP-76, twm, SLP76, m1Khoe
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16822
HGNC: HGNC:6529
Homologene: 4065
Capns2
Name: calpain, small subunit 2
Synonyms: 2310005G05Rik, 30K-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69543
Homologene: 57167
Or52h9
Name: olfactory receptor family 52 subfamily H member 9
Synonyms: GA_x6K02T2PBJ9-7179540-7180481, MOR31-11, Olfr651
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258809
Homologene: 64922
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269902
Homologene: 104832
Hsf5
Name: heat shock transcription factor family member 5
Synonyms: LOC327992
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327992
Homologene: 52701
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234686
Homologene: 136406
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, 2510009N07Rik, autophagin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66615
Homologene: 100868
1700017N19Rik
Name: RIKEN cDNA 1700017N19 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66605
Homologene: 45135
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: Glur-5, Glur5, D16Ium24, A830007B11Rik, D16Ium24e, Glurbeta1, GluK5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Nepn
Name: nephrocan
Synonyms: 5730521E12Rik, Npn, periolin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66650
Homologene: 23549
Elp4
Name: elongator acetyltransferase complex subunit 4
Synonyms: A330107A17Rik, Paxneb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77766
HGNC: HGNC:1171
Homologene: 32433
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20537
Homologene: 55456
Spmap2l
Name: sperm microtubule associated protein 2 like
Synonyms: 1700023E05Rik, Thegl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71868
Homologene: 128474
Icosl
Name: icos ligand
Synonyms: B7h, GL50, ICOS-L, B7RP-1, GL50-B, LICOS, B7-H2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50723
VEGA: 10
Homologene: 49412
Galnt15
Name: polypeptide N-acetylgalactosaminyltransferase 15
Synonyms: 4631401E18Rik, Galntl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78754
Homologene: 14286
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: PNPase, polynucleotide phosphorylase, 1200003F12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71701
Homologene: 12404
Or10d4c
Name: olfactory receptor family 10 subfamily D member 4C
Synonyms: GA_x6K02T2PVTD-33343617-33344561, MOR224-5, Olfr961
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Cep44
Name: centrosomal protein 44
Synonyms: 4933440G23Rik, BC088983
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382010
Homologene: 12738
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, 6330578D22Rik, C230095H21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Asgr2
Name: asialoglycoprotein receptor 2
Synonyms: Asgr-2, Asgr, ASGPR2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11890
HGNC: HGNC:743
Homologene: 912
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Tex47
Name: testis expressed 47
Synonyms: 4921511H03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70920
Homologene: 41723
A630010A05Rik
Name: RIKEN cDNA A630010A05 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545280
Cfap144
Name: cilia and flagella associated protein 144
Synonyms: 3100002J23Rik, Fam183b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75429
Homologene: 28543
Arhgef9
Name: CDC42 guanine nucleotide exchange factor 9
Synonyms: collybistin, 9630036L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236915
Homologene: 9053
Or8b43
Name: olfactory receptor family 8 subfamily B member 43
Synonyms: GA_x6K02T2PVTD-32141623-32142552, MOR169-1, Olfr902
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258798
VEGA: 9
Rpl31-ps17
Name: ribosomal protein L31, pseudogene 17
Synonyms: Gm16382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 673582
B930094E09Rik
Name: RIKEN cDNA B930094E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Gm14277
Name: predicted gene 14277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 105244345
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,188,393 bp
  • T to C, chromosome 1 at 93,784,480 bp
  • T to C, chromosome 2 at 11,256,169 bp
  • T to C, chromosome 2 at 105,904,315 bp
  • T to C, chromosome 2 at 118,439,066 bp
  • A to G, chromosome 2 at 157,168,955 bp
  • C to T, chromosome 2 at 158,757,254 bp
  • C to A, chromosome 2 at 180,981,076 bp
  • T to C, chromosome 3 at 30,814,282 bp
  • A to G, chromosome 4 at 149,214,105 bp
  • G to T, chromosome 5 at 7,305,364 bp
  • G to A, chromosome 5 at 24,439,848 bp
  • T to C, chromosome 5 at 33,154,674 bp
  • A to G, chromosome 5 at 76,915,214 bp
  • T to C, chromosome 5 at 77,054,536 bp
  • T to C, chromosome 5 at 120,542,518 bp
  • T to A, chromosome 6 at 119,926,426 bp
  • T to C, chromosome 7 at 16,276,559 bp
  • T to C, chromosome 7 at 41,426,640 bp
  • T to C, chromosome 7 at 59,276,113 bp
  • T to C, chromosome 7 at 104,553,345 bp
  • T to A, chromosome 7 at 113,540,598 bp
  • G to A, chromosome 8 at 56,538,617 bp
  • T to A, chromosome 8 at 92,901,624 bp
  • T to C, chromosome 8 at 105,337,351 bp
  • A to G, chromosome 9 at 38,449,366 bp
  • A to G, chromosome 9 at 39,647,116 bp
  • T to C, chromosome 9 at 92,601,989 bp
  • C to T, chromosome 9 at 110,067,594 bp
  • T to A, chromosome 9 at 114,617,920 bp
  • T to G, chromosome 10 at 11,186,518 bp
  • T to A, chromosome 10 at 52,391,815 bp
  • T to C, chromosome 10 at 77,935,068 bp
  • C to T, chromosome 10 at 78,071,873 bp
  • C to A, chromosome 10 at 100,605,633 bp
  • A to G, chromosome 11 at 29,153,375 bp
  • G to T, chromosome 11 at 34,078,226 bp
  • A to T, chromosome 11 at 58,796,531 bp
  • G to A, chromosome 11 at 70,105,385 bp
  • T to C, chromosome 11 at 87,631,634 bp
  • A to G, chromosome 11 at 99,001,405 bp
  • T to A, chromosome 12 at 51,598,149 bp
  • C to T, chromosome 12 at 54,701,612 bp
  • T to A, chromosome 12 at 70,042,978 bp
  • C to G, chromosome 13 at 20,600,212 bp
  • T to C, chromosome 13 at 59,822,049 bp
  • C to T, chromosome 14 at 31,284,761 bp
  • A to T, chromosome 14 at 32,058,269 bp
  • A to G, chromosome 14 at 121,562,053 bp
  • A to G, chromosome 15 at 8,121,464 bp
  • A to G, chromosome 16 at 14,618,713 bp
  • A to G, chromosome 16 at 18,956,202 bp
  • A to G, chromosome 16 at 20,501,719 bp
  • T to C, chromosome 16 at 87,923,200 bp
  • T to C, chromosome 18 at 31,609,598 bp
  • T to A, chromosome 18 at 32,083,450 bp
  • C to T, chromosome 19 at 6,049,921 bp
  • T to G, chromosome X at 95,101,064 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4423 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041143-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.