Strain Name:
C57BL/6J-MtgxR4039Btlr/Mmmh
Stock Number:
041614-MU
Citation ID:
RRID:MMRRC_041614-MU
Other Names:
R4039 (G1), C57BL/6J-MtgxR4039Btlr
Major Collection:

Gene Information

Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57138
Homologene: 10665
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: RNCAM, R4B12 antigen, Ncam-2, Ocam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: 1100001C18Rik, A330076K04Rik, 2500002E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70097
Homologene: 69182
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: P19-PTP, PTP-PEST, PTP-P19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: 5830417J06Rik, seladin-1, 3-beta-hydroxysterol delta-24 reductase, 2310076D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Mmachc
Name: methylmalonic aciduria cblC type, with homocystinuria
Synonyms: 1810037K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67096
Homologene: 12082
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Hspb8
Name: heat shock protein 8
Synonyms: HSP20-like, HSP22, D5Ucla4, E2IG1, H11, Cryac, H11K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80888
Homologene: 8654
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: 1110062G02Rik, Nob1, Nobq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57915
Homologene: 56856
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69684
Homologene: 6821
Csn2
Name: casein beta
Synonyms: CSN2, Csnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12991
HGNC: HGNC:2447
Homologene: 1426
Zfp931
Name: zinc finger protein 931
Synonyms: 2810021G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353208
Homologene: 136272
Lyzl1
Name: lysozyme-like 1
Synonyms: 1700038F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67328
Homologene: 81913
Epn2
Name: epsin 2
Synonyms: Ibp2, 9530051D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13855
Homologene: 40710
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: crn, 1200013P10Rik, 5730590A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66877
Homologene: 6462
Gorab
Name: golgin, RAB6-interacting
Synonyms: NTKL-BP1, Scyl1bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98376
Homologene: 45113
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Ttyh1
Name: tweety family member 1
Synonyms: tty, 6330408P11Rik, 4930459B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57776
Homologene: 10779
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239611
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: 2310008I11Rik, AMPKalpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, VDUP1, mVDUP1, Hyplip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70155
Homologene: 11595
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1, RIM1a, C030033M19Rik, RIM1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116837
Homologene: 128399
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Vmn1r218
Name: vomeronasal 1 receptor 218
Synonyms: V1ri5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171256
Homologene: 110880
Plekhh1
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Synonyms: D630024D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211945
VEGA: 12
Homologene: 121939
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 80285
Homologene: 12720
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Rab12
Name: RAB12, member RAS oncogene family
Synonyms: 2900054P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19328
Homologene: 103879
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243937
Homologene: 8813
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Ttbk2
Name: tau tubulin kinase 2
Synonyms: TTK, B930008N24Rik, 2610507N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140810
Homologene: 62795
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230025
Homologene: 11000
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: 9230101H05Rik, Miwi2, MIWI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330890
Homologene: 45122
4933412E24Rik
Name: RIKEN cDNA 4933412E24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71088
VEGA: 15
Homologene: 129990
Trim43b
Name: tripartite motif-containing 43B
Synonyms: Gm8269
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 666747
Homologene: 105432
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70893
Homologene: 72240
Hspa2
Name: heat shock protein 2
Synonyms: 70kDa, Hsp70-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: 1700025P14Rik, 4933437F18Rik, MEX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71861
Homologene: 32689
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TbetaR-II, TbetaRII, 1110020H15Rik, TBR-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Mettl27
Name: methyltransferase like 27
Synonyms: Wbscr27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 79565
Homologene: 11553
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 22,475,712 bp
  • T to C, chromosome 1 at 23,378,964 bp
  • A to G, chromosome 1 at 105,827,739 bp
  • A to T, chromosome 1 at 163,397,066 bp
  • A to G, chromosome 2 at 60,352,995 bp
  • A to T, chromosome 2 at 66,085,327 bp
  • G to A, chromosome 2 at 83,915,994 bp
  • A to T, chromosome 2 at 120,745,795 bp
  • T to A, chromosome 2 at 145,932,327 bp
  • A to G, chromosome 2 at 164,992,330 bp
  • T to A, chromosome 2 at 178,067,984 bp
  • C to A, chromosome 2 at 178,380,927 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • T to G, chromosome 4 at 21,685,774 bp
  • T to C, chromosome 4 at 105,051,247 bp
  • T to C, chromosome 4 at 106,573,878 bp
  • G to T, chromosome 4 at 113,885,814 bp
  • T to A, chromosome 4 at 116,706,018 bp
  • T to C, chromosome 4 at 118,364,952 bp
  • A to T, chromosome 5 at 21,002,510 bp
  • A to G, chromosome 5 at 64,316,428 bp
  • C to T, chromosome 5 at 87,698,076 bp
  • T to C, chromosome 5 at 110,614,208 bp
  • A to G, chromosome 5 at 116,409,344 bp
  • C to T, chromosome 5 at 134,940,609 bp
  • T to C, chromosome 7 at 4,133,346 bp
  • A to T, chromosome 7 at 37,569,550 bp
  • G to A, chromosome 7 at 56,156,411 bp
  • C to T, chromosome 9 at 14,727,536 bp
  • A to C, chromosome 9 at 26,829,047 bp
  • A to G, chromosome 9 at 45,928,007 bp
  • A to G, chromosome 9 at 89,091,347 bp
  • T to C, chromosome 9 at 116,175,037 bp
  • G to T, chromosome 10 at 8,729,627 bp
  • T to C, chromosome 10 at 100,512,401 bp
  • A to G, chromosome 11 at 61,546,522 bp
  • C to A, chromosome 11 at 101,411,925 bp
  • T to C, chromosome 12 at 55,795,701 bp
  • T to C, chromosome 12 at 76,405,768 bp
  • C to A, chromosome 12 at 79,055,183 bp
  • G to A, chromosome 12 at 103,074,949 bp
  • T to C, chromosome 13 at 23,136,801 bp
  • G to A, chromosome 15 at 55,792,020 bp
  • A to T, chromosome 15 at 60,016,366 bp
  • T to A, chromosome 15 at 91,882,631 bp
  • T to C, chromosome 16 at 35,960,047 bp
  • C to T, chromosome 16 at 81,490,323 bp
  • A to T, chromosome 17 at 23,345,103 bp
  • T to C, chromosome 17 at 66,500,401 bp
  • T to C, chromosome 18 at 4,169,140 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4039 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041614-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.