Strain Name:
C57BL/6J-MtgxR4063Btlr/Mmmh
Stock Number:
041619-MU
Citation ID:
RRID:MMRRC_041619-MU
Other Names:
R4063 (G1), C57BL/6J-MtgxR4063Btlr
Major Collection:

Gene Information

Msx1
Name: msh homeobox 1
Synonyms: Hox7, muscle-segment homeobox, Hox7.1, msh, Hox-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17701
HGNC: HGNC:7391
Homologene: 1836
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: ESP1, PRCE, Cerp, SSE, PRCE, separase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Txndc2
Name: thioredoxin domain containing 2 (spermatozoa)
Synonyms: Sptrx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213272
VEGA: 17
Homologene: 41856
Upp1
Name: uridine phosphorylase 1
Synonyms: UPase, UdRPase, Up
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22271
Homologene: 2524
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81000
Homologene: 56698
Dock1
Name: dedicator of cytokinesis 1
Synonyms: b2b3190Clo, D630004B07Rik, Dock180, 9130006G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2810470K03Rik, 2600016M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Kdm6a
Name: lysine (K)-specific demethylase 6A
Synonyms: Utx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22289
Homologene: 7586
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Uhrf1bp1l
Name: UHRF1 (ICBP90) binding protein 1-like
Synonyms: E030041M21Rik, 2010319N22Rik, 4930506D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Sdha
Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms: 2310034D06Rik, SDHF, SDH2, FP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66945
Homologene: 3073
Zfp292
Name: zinc finger protein 292
Synonyms: Krox-10, 9430062L07Rik, Zn-16, 5730450D02Rik, Zn-15, Zfp15, Zfp-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Vim
Name: vimentin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22352
Homologene: 2538
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7a, Dnahc7, LOC381341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Il22ra2
Name: interleukin 22 receptor, alpha 2
Synonyms: Il-22bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237310
Homologene: 18657
Fat1
Name: FAT atypical cadherin 1
Synonyms: 2310038E12Rik, mFat1, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
M1ap
Name: meiosis 1 associated protein
Synonyms: D6Mm5e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110958
Homologene: 13210
Atl2
Name: atlastin GTPase 2
Synonyms: Aip-2, Arl6ip2, 2010110I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: wa3, IASPP, NFkB interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 333654
Homologene: 84635
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67419
Homologene: 12127
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: p190RhoGEF, Rho specific exchange factor, RhoGEF, RIP2, 9230110L08Rik, Rgnef, D13Bwg1089e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1154Clo, Mdnah5, b2b1565Clo, b2b1537Clo, Dnahc5, b2b3491Clo, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Trpc3
Name: transient receptor potential cation channel, subfamily C, member 3
Synonyms: Trp3, Trrp3, Trcp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22065
Homologene: 20708
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, alcadein-beta, CSTN3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232370
Homologene: 22836
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108151
Homologene: 23664
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72094
Homologene: 55988
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2A, Sur2, SUR2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Olfr205
Name: olfactory receptor 205
Synonyms: MOR182-11P, GA_x54KRFPKG5P-55543875-55542958
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 257881
Homologene: 79469
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: TRPP8, Trp-p8, CMR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 171382
Homologene: 23433
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229595
Homologene: 23141
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: Eif2c4, 5730550L01Rik, argonaute 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76850
Homologene: 41184
H2-M2
Name: histocompatibility 2, M region locus 2
Synonyms: Thy19.4, H-2M2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14990
Homologene: 133732
Pramel21
Name: PRAME like 21
Synonyms: Gm13083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 279185
Homologene: 133722
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74762
Homologene: 17780
Zdhhc14
Name: zinc finger, DHHC domain containing 14
Synonyms: New1cp, B530001K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224454
VEGA: 17
Homologene: 62301
Hmgcl
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15356
HGNC: HGNC:5005
Homologene: 159
Proz
Name: protein Z, vitamin K-dependent plasma glycoprotein
Synonyms: 1300015B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66901
HGNC: HGNC:9460
Homologene: 2890
1700034J05Rik
Name: RIKEN cDNA 1700034J05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73344
Homologene: 53485
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74464
Homologene: 18958
Tchh
Name: trichohyalin
Synonyms: Thh, AHF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99681
Homologene: 136273
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Mrvi1, Ris1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Prss50
Name: protease, serine 50
Synonyms: Tsp50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235631
Homologene: 8314
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627569
Homologene: 129606
Otop2
Name: otopetrin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237987
Homologene: 27803
Tmprss11d
Name: transmembrane protease, serine 11d
Synonyms: AsP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231382
Homologene: 74519
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76306
Homologene: 33473
Pramel29
Name: PRAME like 29
Synonyms: C87977
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 97187
Homologene: 103830
Gm15911
Name: predicted gene 15911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Lipf
Name: lipase, gastric
Synonyms: 2310051B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67717
HGNC: HGNC:6622
Homologene: 68139
C8g
Name: complement component 8, gamma polypeptide
Synonyms: 1700013L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69379
HGNC: HGNC:1354
Homologene: 505
Mpnd
Name: MPN domain containing
Synonyms: E130307M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68047
Homologene: 12231
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71706
Homologene: 41733
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: neuferricin, 9330151E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192986
Homologene: 14701
Gm5321
Name: predicted gene 5321
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384525
Gm10719
Name: predicted gene 10719
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 53,425,217 bp
  • G to A, chromosome 1 at 88,362,005 bp
  • A to G, chromosome 2 at 13,580,016 bp
  • A to T, chromosome 2 at 25,499,413 bp
  • T to C, chromosome 3 at 36,671,023 bp
  • T to C, chromosome 3 at 93,446,991 bp
  • T to C, chromosome 3 at 95,677,554 bp
  • A to G, chromosome 4 at 34,810,863 bp
  • G to A, chromosome 4 at 116,877,980 bp
  • A to T, chromosome 4 at 126,515,862 bp
  • T to C, chromosome 4 at 135,958,724 bp
  • A to G, chromosome 4 at 143,615,989 bp
  • T to C, chromosome 4 at 144,208,695 bp
  • T to A, chromosome 5 at 12,585,124 bp
  • C to A, chromosome 5 at 37,824,021 bp
  • T to C, chromosome 5 at 86,309,318 bp
  • T to C, chromosome 5 at 87,336,866 bp
  • A to T, chromosome 5 at 109,092,192 bp
  • G to A, chromosome 5 at 147,879,710 bp
  • A to T, chromosome 6 at 83,003,775 bp
  • A to T, chromosome 6 at 124,449,833 bp
  • T to C, chromosome 6 at 142,605,919 bp
  • A to T, chromosome 6 at 146,953,108 bp
  • A to T, chromosome 7 at 6,019,320 bp
  • A to T, chromosome 7 at 19,370,053 bp
  • G to T, chromosome 7 at 110,923,777 bp
  • G to T, chromosome 7 at 130,729,122 bp
  • A to T, chromosome 7 at 135,115,292 bp
  • A to G, chromosome 8 at 13,064,621 bp
  • A to T, chromosome 8 at 45,025,481 bp
  • A to G, chromosome 8 at 70,781,194 bp
  • G to T, chromosome 9 at 3,019,043 bp
  • T to A, chromosome 9 at 106,720,414 bp
  • A to G, chromosome 9 at 110,858,412 bp
  • A to T, chromosome 10 at 19,626,652 bp
  • A to T, chromosome 10 at 23,805,981 bp
  • A to G, chromosome 10 at 89,816,055 bp
  • A to T, chromosome 10 at 107,790,649 bp
  • A to G, chromosome 10 at 116,537,396 bp
  • C to A, chromosome 11 at 9,131,709 bp
  • A to T, chromosome 11 at 72,795,780 bp
  • G to A, chromosome 11 at 115,329,375 bp
  • C to A, chromosome 13 at 55,608,339 bp
  • A to G, chromosome 13 at 74,323,958 bp
  • T to C, chromosome 13 at 97,994,067 bp
  • T to A, chromosome 14 at 49,773,987 bp
  • T to C, chromosome 15 at 28,420,998 bp
  • A to G, chromosome 15 at 102,312,989 bp
  • A to C, chromosome 16 at 59,328,880 bp
  • G to T, chromosome 17 at 5,752,708 bp
  • A to G, chromosome 17 at 29,838,031 bp
  • G to A, chromosome 17 at 37,481,508 bp
  • A to G, chromosome 17 at 56,009,430 bp
  • A to G, chromosome 17 at 65,638,084 bp
  • T to C, chromosome 17 at 79,850,159 bp
  • A to T, chromosome 19 at 9,883,778 bp
  • A to G, chromosome 19 at 33,965,565 bp
  • A to G, chromosome X at 18,250,875 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4063 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041619-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.