Strain Name:
C57BL/6J-MtgxR4198Btlr/Mmmh
Stock Number:
041640-MU
Citation ID:
RRID:MMRRC_041640-MU
Other Names:
R4198 (G1), C57BL/6J-MtgxR4198Btlr
Major Collection:

Gene Information

Kera
Name: keratocan
Synonyms: SLRR2B, CNA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16545
VEGA: 10
HGNC: HGNC:6309
Homologene: 5106
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170750
Homologene: 6424
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Estm14, C230057C06Rik, Grg1, Tle4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21885
Homologene: 21058
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cux, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Zfp26
Name: zinc finger protein 26
Synonyms: Zfp70, Zfp81-rs1, KRAB15, Zfp-26, mkr-3, 5033428C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22688
Homologene: 52318
Mff
Name: mitochondrial fission factor
Synonyms: 5230400G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75734
Homologene: 87000
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, repro4, Mtap2, MAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Stard8
Name: START domain containing 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236920
Homologene: 22837
Trim29
Name: tripartite motif-containing 29
Synonyms: 4732461M22Rik, 2810431N19Rik, 1110047J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72169
VEGA: 9
Homologene: 8100
Selenop
Name: selenoprotein P
Synonyms: Sepp1, selp, D15Ucla1, Se-P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20363
Homologene: 3945
Atp10a
Name: ATPase, class V, type 10A
Synonyms: Atp10c, pfatp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11982
Homologene: 56461
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
Slc1a1
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms: EAAC1, D130048G10Rik, MEAAC1, EAAT3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20510
Homologene: 20881
Zhx2
Name: zinc fingers and homeoboxes 2
Synonyms: Raf, Afr1, Afr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 387609
Homologene: 8968
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: 2810409M01Rik, ZFYVE7, Mem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17281
Homologene: 11561
Ccny
Name: cyclin Y
Synonyms: 5730405I09Rik, 3110050L10Rik, 4631402G10Rik, 1700025H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67974
VEGA: 18
Homologene: 12219
Aox1
Name: aldehyde oxidase 1
Synonyms: Aox2, retinal oxidase, Aox-1, Aox-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26564
Homologene: 55831
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329942
Homologene: 89034
Gpi-ps
Name: glucose-6-phosphate isomerase, pseudogene
Synonyms: Gm1840, LOC233995
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 669429
Lnpk
Name: lunapark, ER junction formation factor
Synonyms: lunapark, Lnp, 4921514L11Rik, Lnpk1, 9530051D01Rik, 2310011O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69605
Homologene: 12319
Olfr1357
Name: olfactory receptor 1357
Synonyms: MOR128-4, MOR128-3, GA_x6K02T2QGN0-3196801-3197742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 257883
HGNC: HGNC:8207
Homologene: 72920
Serpinb9d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9d
Synonyms: ovalbumin, AT2, Spi9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20726
HGNC: HGNC:8955
Homologene: 69093
Stxbp3-ps
Name: syntaxin-binding protein 3, pseudogene
Synonyms: Stxbp3b, Munc18c(L)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 619371
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, BF-1, 2900064B05Rik, Bf1, Hfhbf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12549
Homologene: 10644
Cdca5
Name: cell division cycle associated 5
Synonyms: 2610036L13Rik, sororin p35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67849
Homologene: 49860
Ces1g
Name: carboxylesterase 1G
Synonyms: Ces1, Ces-1, Ses-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223723
Homologene: 9036
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Orp150, 140 kDa, Grp170, Cab140, CBP-140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12282
Homologene: 4658
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54201
Homologene: 69231
Olfr573-ps1
Name: olfactory receptor 573, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-5653743-5652872, MOR10-4, MOR10-3P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258230
Olfr1381
Name: olfactory receptor 1381
Synonyms: GA_x6K02T2QP88-5884501-5883566, MOR256-26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258461
Homologene: 72463
Snx20
Name: sorting nexin 20
Synonyms: 9130017C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71607
Homologene: 12399
Olfr97
Name: olfactory receptor 97
Synonyms: MOR156-2, GA_x6K02T2PSCP-1672287-1671355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258505
Homologene: 133051
Stx19
Name: syntaxin 19
Synonyms: A030009B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68159
Homologene: 55777
Sowaha
Name: sosondowah ankyrin repeat domain family member A
Synonyms: A830006N08Rik, Ankrd43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237761
Homologene: 18488
Syp
Name: synaptophysin
Synonyms: Syn, A230093K24Rik, p38, Syp I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 20977
Homologene: 2391
Fam122c
Name: family with sequence similarity 122, member C
Synonyms: 4930527G05Rik, 4930432H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73866
Homologene: 87062
Mir7235
Name: microRNA 7235
Synonyms: mmu-mir-7235
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 102466822
VEGA: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,085,607 bp
  • C to T, chromosome 1 at 66,425,298 bp
  • T to G, chromosome 1 at 82,735,532 bp
  • T to C, chromosome 2 at 74,569,109 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to G, chromosome 4 at 72,118,267 bp
  • A to G, chromosome 4 at 128,510,924 bp
  • T to A, chromosome 5 at 136,286,848 bp
  • T to C, chromosome 5 at 143,254,471 bp
  • A to G, chromosome 7 at 58,813,686 bp
  • A to G, chromosome 7 at 102,941,797 bp
  • C to T, chromosome 7 at 119,922,838 bp
  • T to A, chromosome 8 at 5,640,368 bp
  • A to G, chromosome 8 at 88,627,598 bp
  • A to G, chromosome 8 at 93,305,868 bp
  • A to T, chromosome 8 at 121,609,154 bp
  • T to C, chromosome 9 at 20,436,716 bp
  • G to T, chromosome 9 at 43,311,380 bp
  • G to A, chromosome 9 at 44,388,859 bp
  • T to C, chromosome 9 at 123,826,634 bp
  • A to T, chromosome 10 at 78,612,067 bp
  • T to C, chromosome 10 at 97,612,973 bp
  • G to A, chromosome 11 at 49,552,634 bp
  • T to C, chromosome 11 at 53,478,568 bp
  • C to A, chromosome 11 at 83,342,603 bp
  • C to T, chromosome 11 at 97,149,068 bp
  • T to G, chromosome 11 at 114,863,860 bp
  • T to A, chromosome 12 at 49,385,299 bp
  • A to G, chromosome 13 at 33,202,674 bp
  • A to G, chromosome 13 at 33,202,965 bp
  • A to G, chromosome 13 at 53,110,644 bp
  • C to A, chromosome 15 at 3,274,718 bp
  • A to G, chromosome 15 at 57,821,729 bp
  • T to C, chromosome 15 at 83,577,013 bp
  • G to A, chromosome 16 at 38,623,913 bp
  • G to T, chromosome 16 at 62,822,676 bp
  • T to A, chromosome 17 at 37,232,134 bp
  • G to A, chromosome 18 at 9,332,928 bp
  • T to C, chromosome 19 at 6,090,352 bp
  • T to C, chromosome 19 at 9,558,357 bp
  • A to G, chromosome 19 at 28,901,452 bp
  • G to A, chromosome 19 at 52,996,973 bp
  • A to G, chromosome X at 7,639,927 bp
  • G to A, chromosome X at 53,293,499 bp
  • AGAGGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGAGGA, chromosome X at 99,066,508 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4198 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041640-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.