Strain Name:
C57BL/6J-MtgxR4329Btlr/Mmmh
Stock Number:
041663-MU
Citation ID:
RRID:MMRRC_041663-MU
Other Names:
R4329 (G1), C57BL/6J-MtgxR4329Btlr
Major Collection:

Strain Information

Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: trp2, TRPC2a, mTrp2, Trrp2, TRPC2b, 3010009O07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Chka
Name: choline kinase alpha
Synonyms: Chk, choline/ethanolamine kinase alpha, EtnK-alpha, ChoK, CK/EK-alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12660
HGNC: HGNC:1937
Homologene: 88575
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: mSin3A, Sin3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20466
Homologene: 32124
Palm
Name: paralemmin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18483
VEGA: 10
HGNC: HGNC:8594
Homologene: 1937
Ipo8
Name: importin 8
Synonyms: OM-1, Ranbp8, Om1, C130009K11Rik, 6230418K12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Nova1
Name: NOVA alternative splicing regulator 1
Synonyms: 9430099M15Rik, Nova-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 664883
VEGA: 12
HGNC: HGNC:7886
Homologene: 21296
Strada
Name: STE20-related kinase adaptor alpha
Synonyms: 6030402H20Rik, 2610019A05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72149
Homologene: 12448
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: Semaj, M-sema G, CD100, semaphorin H, Semacl2, coll-4, Semcl2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20354
Homologene: 21282
Cd55
Name: CD55 molecule, decay accelerating factor for complement
Synonyms: GPI-DAF, complement-glycosylphosphatidylinositol, Daf1, Cromer blood group, Daf-GPI
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13136
HGNC: HGNC:2665
Homologene: 479
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, E130018M02Rik, mGluR7, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, D10Bwg0792e, Unc5h2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Pnkp
Name: polynucleotide kinase 3'- phosphatase
Synonyms: 1810009G08Rik, PNK
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 59047
HGNC: HGNC:9154
Homologene: 5247
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Mpp3
Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms: Dlgh3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13384
HGNC: HGNC:7221
Homologene: 31065
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: 1200014F01Rik, Ampd-2, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Cand2
Name: cullin associated and neddylation dissociated 2 (putative)
Synonyms: 2210404G23Rik, Tp120b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67088
Homologene: 41657
Zfta
Name: zinc finger translocation associated
Synonyms: 2700081O15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108899
Homologene: 52179
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, Sec3l1, 2810407P21Rik, A730011E05Rik, SEC3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Ttyh1
Name: tweety family member 1
Synonyms: 6330408P11Rik, 4930459B04Rik, tty
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57776
Homologene: 10779
Klk4
Name: kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
Synonyms: Prss17, ESMP1, KLK-L1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56640
HGNC: HGNC:6365
Homologene: 55856
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Ttc8
Name: tetratricopeptide repeat domain 8
Synonyms: 0610012F22Rik, BBS8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76260
Homologene: 14988
Patl2
Name: protein associated with topoisomerase II homolog 2 (yeast)
Synonyms: 4930424G05Rik, Pat1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67578
Homologene: 12155
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Xylt1
Name: xylosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233781
Homologene: 32534
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, Cav1.1, muscle dysgenesis, DHPR alpha1s, mdg, sj, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: Cspg4a, AN2, 4732461B14Rik, NG2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Adamts15
Name: ADAM metallopeptidase with thrombospondin type 1 motif 15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: b2b1654Clo, Ccdc164, Gm1060, LOC381738
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Ang2
Name: angiogenin, ribonuclease A family, member 2
Synonyms: Angrp, Rnase5b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11731
VEGA: 14
HGNC: HGNC:483
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: A630007B06Rik, Otg1, 1810028B20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 213993
Homologene: 9963
Ro60
Name: Ro60, Y RNA binding protein
Synonyms: 1810007I17Rik, SS-A/Ro, Trove2, Ssa2, Ssa, A530054J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20822
Homologene: 3383
Skint9
Name: selection and upkeep of intraepithelial T cells 9
Synonyms: A030013N09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329918
Homologene: 136292
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: Gm6095, 4921529N20Rik, 4933402B14Rik, Tmem146
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Fbxw22
Name: F-box and WD-40 domain protein 22
Synonyms: Gm5164
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382156
Homologene: 110776
Pak3
Name: p21 (RAC1) activated kinase 3
Synonyms: PAK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 18481
HGNC: HGNC:8592
Homologene: 55664
Zfp827
Name: zinc finger protein 827
Synonyms: D630040G17Rik, 2810449M09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622675
Homologene: 45622
Or7g34
Name: olfactory receptor family 7 subfamily G member 34
Synonyms: Olfr854, GA_x6K02T2PVTD-13313295-13312357, MOR147-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258515
Homologene: 128144
Rdm1
Name: RAD52 motif 1
Synonyms: Rad52b, 2410008M22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66599
Homologene: 11992
Yipf7
Name: Yip1 domain family, member 7
Synonyms: Yip1b, 2310016N21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75581
Homologene: 69367
Ccdc142os
Name: coiled-coil domain containing 142, opposite strand
Synonyms: Gm15605
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Slc16a13
Name: solute carrier family 16 (monocarboxylic acid transporters), member 13
Synonyms: 1700007D07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69309
Homologene: 71749
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Stambpl1
Name: STAM binding protein like 1
Synonyms: 8230401J17Rik, 1700095N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76630
Homologene: 23253
Gm5263
Name: predicted gene 5263
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383571
Esp1
Name: exocrine gland secreted peptide 1
Synonyms: Gm6084, ESP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619517
Pkmyt1
Name: protein kinase, membrane associated tyrosine/threonine 1
Synonyms: Myt1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268930
VEGA: 17
Homologene: 31227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 46,649,281 bp
  • T to A, chromosome 1 at 100,072,163 bp
  • A to T, chromosome 1 at 130,452,483 bp
  • A to C, chromosome 1 at 136,119,033 bp
  • G to A, chromosome 1 at 143,766,707 bp
  • A to G, chromosome 1 at 146,420,691 bp
  • C to T, chromosome 2 at 122,127,537 bp
  • C to A, chromosome 3 at 108,077,787 bp
  • G to A, chromosome 4 at 82,986,537 bp
  • A to C, chromosome 4 at 112,391,865 bp
  • A to T, chromosome 5 at 30,355,658 bp
  • A to T, chromosome 5 at 69,521,122 bp
  • T to A, chromosome 5 at 76,567,975 bp
  • C to A, chromosome 5 at 113,095,589 bp
  • T to A, chromosome 6 at 83,107,016 bp
  • T to C, chromosome 6 at 110,914,364 bp
  • C to A, chromosome 6 at 115,799,988 bp
  • A to T, chromosome 6 at 148,800,164 bp
  • A to T, chromosome 7 at 4,130,581 bp
  • A to G, chromosome 7 at 43,884,406 bp
  • T to C, chromosome 7 at 44,858,594 bp
  • T to C, chromosome 7 at 102,087,520 bp
  • A to T, chromosome 7 at 105,753,759 bp
  • G to A, chromosome 7 at 117,656,461 bp
  • G to A, chromosome 8 at 79,189,834 bp
  • A to T, chromosome 9 at 3,458,878 bp
  • T to A, chromosome 9 at 19,567,022 bp
  • T to C, chromosome 9 at 30,904,518 bp
  • T to C, chromosome 9 at 56,892,465 bp
  • T to C, chromosome 9 at 57,095,358 bp
  • C to T, chromosome 9 at 108,846,049 bp
  • T to A, chromosome 9 at 109,384,043 bp
  • A to G, chromosome 10 at 60,783,190 bp
  • T to C, chromosome 10 at 61,863,979 bp
  • G to A, chromosome 10 at 79,807,686 bp
  • C to T, chromosome 10 at 100,537,668 bp
  • T to C, chromosome 11 at 70,217,897 bp
  • T to A, chromosome 11 at 101,630,908 bp
  • T to C, chromosome 11 at 102,023,511 bp
  • A to G, chromosome 11 at 106,187,173 bp
  • A to T, chromosome 12 at 46,720,832 bp
  • T to C, chromosome 12 at 98,946,586 bp
  • T to C, chromosome 13 at 51,703,304 bp
  • A to T, chromosome 14 at 51,195,868 bp
  • T to A, chromosome 15 at 4,931,379 bp
  • C to T, chromosome 15 at 31,498,741 bp
  • G to A, chromosome 16 at 94,466,961 bp
  • T to A, chromosome 17 at 23,732,735 bp
  • C to A, chromosome 17 at 34,693,864 bp
  • A to G, chromosome 17 at 40,728,877 bp
  • T to A, chromosome 17 at 56,654,517 bp
  • C to T, chromosome 17 at 71,036,353 bp
  • A to T, chromosome 18 at 37,401,822 bp
  • G to T, chromosome 18 at 37,401,823 bp
  • A to T, chromosome 18 at 61,071,720 bp
  • T to C, chromosome 19 at 3,875,803 bp
  • A to G, chromosome 19 at 7,421,226 bp
  • G to T, chromosome 19 at 29,743,561 bp
  • T to C, chromosome 19 at 34,234,122 bp
  • T to C, chromosome 19 at 56,793,502 bp
  • T to C, chromosome X at 143,733,209 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4329 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041663-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.