Strain Name:
C57BL/6J-MtgxR4486Btlr/Mmmh
Stock Number:
041742-MU
Citation ID:
RRID:MMRRC_041742-MU
Other Names:
R4486 (G1), C57BL/6J-MtgxR4486Btlr
Major Collection:

Gene Information

Ngf
Name: nerve growth factor
Synonyms: Ngfb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18049
HGNC: HGNC:7808
Homologene: 1876
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70508
Homologene: 10634
Helz
Name: helicase with zinc finger domain
Synonyms: 9630002H22Rik, 9430093I07Rik, 3110078M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78455
Homologene: 8918
Kifbp
Name: kinesin family binding protein
Synonyms: 2510003E04Rik, Kif1bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72320
Homologene: 9223
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74355
Homologene: 23665
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Armc10
Name: armadillo repeat containing 10
Synonyms: 2810037C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67211
Homologene: 12097
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230249
Homologene: 6056
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 83691
Homologene: 12857
Xrcc4
Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms: 2310057B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 108138
Homologene: 2555
Trim37
Name: tripartite motif-containing 37
Synonyms: MUL, TEF3, 2810004E07Rik, 1110032A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68729
HGNC: HGNC:7523
Homologene: 9084
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: mGluR6, nerg1, nob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Tro
Name: trophinin
Synonyms: necdin and trophinin like, Tnn, trophinin-2, magphinin-gamma, magphinin-beta 2, magphinin-alpha, magphinin, Maged3l, Maged3, Trol
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 56191
Homologene: 75113
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11864
Homologene: 7230
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: beta4GalT-III, ESTM26, 9530061M23Rik, R74981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637896
Homologene: 115466
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: 4632401C08Rik, B0AT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74338
Homologene: 52819
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 208936
Homologene: 65241
Tas2r143
Name: taste receptor, type 2, member 143
Synonyms: mt2r36, Tas2r43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387514
Homologene: 74285
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Trbc2
Name: T cell receptor beta, constant 2
Synonyms: BB153276, Tcrb-C2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100125263
Rpusd2
Name: RNA pseudouridylate synthase domain containing 2
Synonyms: 4921503C21Rik, BB231107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271842
Homologene: 5588
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666085
Homologene: 104040
Olfr813
Name: olfactory receptor 813
Synonyms: GA_x6K02T2PULF-11535078-11536010, MOR108-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258252
Homologene: 138308
Nanog
Name: Nanog homeobox
Synonyms: 2410002E02Rik, ENK, ecat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71950
Homologene: 78027
Frk
Name: fyn-related kinase
Synonyms: BSK/IYK, GTK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14302
VEGA: 10
HGNC: HGNC:3955
Homologene: 48065
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Abcd2
Name: ATP-binding cassette, sub-family D (ALD), member 2
Synonyms: ALDR, ALDL1, adrenoleukodystrophy related, ABC39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Thrb
Name: thyroid hormone receptor beta
Synonyms: T3Rbeta, T3R[b], Nr1a2, TR beta, c-erbAbeta, Thrb2, Thrb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21834
Homologene: 36025
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Hyi
Name: hydroxypyruvate isomerase (putative)
Synonyms: 2700033B16Rik, 6430559E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68180
Bud23
Name: BUD23, rRNA methyltransferase and ribosome maturation factor
Synonyms: 1110003N24Rik, Wbscr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66138
Homologene: 5486
Olfr676
Name: olfactory receptor 676
Synonyms: GA_x6K02T2PBJ9-7664016-7664969, MOR32-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259099
Homologene: 64955
Jrkl
Name: Jrk-like
Synonyms: C030035D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77532
VEGA: 9
HGNC: HGNC:6200
Homologene: 2797
Ulbp1
Name: UL16 binding protein 1
Synonyms: MULT1, A430108B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77777
VEGA: 10
Homologene: 108274
Rpl7a-ps3
Name: ribosomal protein L7A, pseudogene 3
Synonyms: Gm5044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268795
VEGA: 15
Cnga2
Name: cyclic nucleotide gated channel alpha 2
Synonyms: OCNC1, Cnca, Cncg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 12789
HGNC: HGNC:2149
Homologene: 32022
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
B430119L08Rik
Name: RIKEN cDNA B430119L08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Gm21759
Name: predicted gene, 21759
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 102633023
Zfp994
Name: zinc finger protein 994
Synonyms: Gm4944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240038
VEGA: 17
Homologene: 133246
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 17,752,878 bp
  • A to G, chromosome 1 at 171,271,773 bp
  • T to C, chromosome 2 at 119,035,224 bp
  • T to A, chromosome 3 at 98,882,025 bp
  • G to A, chromosome 3 at 102,520,699 bp
  • A to G, chromosome 4 at 58,820,086 bp
  • G to A, chromosome 4 at 118,362,477 bp
  • A to T, chromosome 5 at 8,180,227 bp
  • A to G, chromosome 5 at 21,653,434 bp
  • T to C, chromosome 5 at 135,063,925 bp
  • A to G, chromosome 6 at 41,546,880 bp
  • A to G, chromosome 6 at 42,400,694 bp
  • A to G, chromosome 6 at 73,038,746 bp
  • T to C, chromosome 6 at 122,712,717 bp
  • A to T, chromosome 7 at 12,632,272 bp
  • T to A, chromosome 7 at 13,337,751 bp
  • A to G, chromosome 7 at 23,321,227 bp
  • T to A, chromosome 7 at 84,275,345 bp
  • A to C, chromosome 7 at 86,920,751 bp
  • T to C, chromosome 7 at 105,035,303 bp
  • T to C, chromosome 7 at 119,825,577 bp
  • G to T, chromosome 8 at 113,713,193 bp
  • T to C, chromosome 9 at 13,245,371 bp
  • T to A, chromosome 10 at 7,447,397 bp
  • T to C, chromosome 10 at 34,608,381 bp
  • A to G, chromosome 10 at 62,563,027 bp
  • C to T, chromosome 10 at 70,001,974 bp
  • T to C, chromosome 10 at 129,856,698 bp
  • T to C, chromosome 11 at 50,859,989 bp
  • T to A, chromosome 11 at 87,196,825 bp
  • C to A, chromosome 11 at 107,637,874 bp
  • T to A, chromosome 12 at 103,897,000 bp
  • A to T, chromosome 13 at 73,681,717 bp
  • A to C, chromosome 13 at 89,992,588 bp
  • G to T, chromosome 14 at 17,925,640 bp
  • G to A, chromosome 15 at 36,308,283 bp
  • A to G, chromosome 15 at 91,178,283 bp
  • A to G, chromosome 16 at 50,200,414 bp
  • C to T, chromosome 17 at 22,201,560 bp
  • T to A, chromosome 17 at 32,483,454 bp
  • T to C, chromosome 17 at 71,407,235 bp
  • T to C, chromosome 18 at 36,947,351 bp
  • T to A, chromosome X at 72,006,127 bp
  • T to C, chromosome X at 150,653,325 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4486 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041742-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.