Strain Name:
C57BL/6J-MtgxR4516Btlr/Mmmh
Stock Number:
041760-MU
Citation ID:
RRID:MMRRC_041760-MU
Other Names:
R4516 (G1), C57BL/6J-MtgxR4516Btlr
Major Collection:

Gene Information

Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: Cerp, PRCE, ESP1, separase, PRCE, SSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105988
VEGA: 15
Homologene: 32151
Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Snx17
Name: sorting nexin 17
Synonyms: 5830447M19Rik, b2b1625.1Clo, D5Ertd260e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 266781
Homologene: 8838
Got1
Name: glutamic-oxaloacetic transaminase 1, soluble
Synonyms: Got-1, cytosolic aspartate aminotransferase, cAspAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14718
HGNC: HGNC:4432
Homologene: 1571
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21899
Homologene: 21223
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74195
VEGA: 14
Homologene: 7105
Xpa
Name: xeroderma pigmentosum, complementation group A
Synonyms: Xpac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22590
Homologene: 37298
Pdxdc1
Name: pyridoxal-dependent decarboxylase domain containing 1
Synonyms: 2210010A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 94184
Homologene: 22858
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98732
Homologene: 40842
Fbxl20
Name: F-box and leucine-rich repeat protein 20
Synonyms: Fbl2, C86145, Scr, Scrapper, 2610511F20Rik, 4632423N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72194
Homologene: 68784
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214444
Homologene: 49533
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229227
Homologene: 52105
Vps26a
Name: VPS26 retromer complex component A
Synonyms: H beta 58, Vps26, HB58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 30930
VEGA: 10
Homologene: 68420
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C030046E11Rik, C130057E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226089
Homologene: 13806
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100072
Homologene: 18942
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80883
Homologene: 8949
Coq7
Name: demethyl-Q 7
Synonyms: clk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12850
HGNC: HGNC:2244
Homologene: 6953
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, TIF-2, D1Ertd433e, TIF2, Grip1, bHLHe75, glucocorticoid receptor-interacting protein 1, KAT13C, TIF2/GRIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Cntrl
Name: centriolin
Synonyms: b2b1468Clo, 6720467O09Rik, IB3/5, Cep110, Cep1, Ma2a8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Pax7
Name: paired box 7
Synonyms: Pax-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18509
HGNC: HGNC:8621
Homologene: 55665
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233651
Homologene: 2771
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 15257
Homologene: 56483
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 212517
Homologene: 75085
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245026
Homologene: 18260
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16564
VEGA: 15
Homologene: 56761
Ubqlnl
Name: ubiquilin-like
Synonyms: 4922504M18Rik, LOC244179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244179
Homologene: 17034
Olfr389
Name: olfactory receptor 389
Synonyms: MOR135-6, GA_x6K02T2P1NL-3932085-3931147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 259011
Homologene: 85925
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Bean1
Name: brain expressed, associated with Nedd4, 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 65115
Homologene: 110172
Gm10722
Name: predicted gene 10722
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
4930452B06Rik
Name: RIKEN cDNA 4930452B06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74430
Homologene: 18873
1110017D15Rik
Name: RIKEN cDNA 1110017D15 gene
Synonyms: Cbe1, Smrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73721
Homologene: 13074
Elmo1
Name: engulfment and cell motility 1
Synonyms: 6330578D22Rik, C230095H21Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 140580
Homologene: 56685
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71007
Homologene: 18998
Dzank1
Name: double zinc ribbon and ankyrin repeat domains 1
Synonyms: 2810039F03Rik, 6330439K17Rik, Ankrd64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241688
Homologene: 10037
Slc47a1
Name: solute carrier family 47, member 1
Synonyms: MATE1, 1300013J15Rik, mMATE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67473
Homologene: 34364
Gm16286
Name: predicted gene 16286
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Tas2r116
Name: taste receptor, type 2, member 116
Synonyms: Tas2r14, Tas2r16, mGR16, T2R16, TRB1, Tas2r7, mt2r56, TRB4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 112408
Homologene: 130070
Vmn1r174
Name: vomeronasal 1 receptor 174
Synonyms: V1rd22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 404291
Homologene: 79577
Gm1673
Name: predicted gene 1673
Synonyms: LOC381633
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381633
Homologene: 134513
Tmem106b
Name: transmembrane protein 106B
Synonyms: 2310036D22Rik, 5830455K21Rik, 6430519M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71900
Homologene: 56806
Olfr1229
Name: olfactory receptor 1229
Synonyms: GA_x6K02T2Q125-50727797-50726862, MOR233-22, MOR233-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257921
Homologene: 79376
Rab29
Name: RAB29, member RAS oncogene family
Synonyms: Rab7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226422
HGNC: HGNC:9789
Homologene: 20842
Gm10369
Name: predicted gene 10369
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100038504
Gm4459
Name: predicted gene 4459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100043472
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105734
Homologene: 129878
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 13,146,906 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • A to T, chromosome 1 at 131,867,731 bp
  • G to A, chromosome 1 at 185,267,068 bp
  • G to A, chromosome 2 at 35,127,981 bp
  • T to A, chromosome 2 at 89,282,843 bp
  • T to A, chromosome 2 at 144,510,122 bp
  • T to C, chromosome 3 at 36,895,311 bp
  • G to T, chromosome 3 at 103,750,372 bp
  • A to G, chromosome 3 at 109,935,013 bp
  • T to C, chromosome 4 at 41,517,200 bp
  • T to C, chromosome 4 at 46,157,824 bp
  • A to T, chromosome 4 at 70,276,715 bp
  • T to G, chromosome 4 at 139,780,793 bp
  • A to G, chromosome 4 at 151,144,720 bp
  • A to G, chromosome 5 at 31,197,683 bp
  • G to A, chromosome 5 at 33,983,681 bp
  • A to G, chromosome 5 at 64,954,904 bp
  • A to G, chromosome 5 at 86,047,587 bp
  • A to T, chromosome 5 at 120,919,170 bp
  • A to G, chromosome 5 at 134,676,786 bp
  • C to T, chromosome 6 at 13,075,099 bp
  • T to C, chromosome 6 at 132,856,150 bp
  • A to G, chromosome 7 at 23,754,343 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • C to T, chromosome 7 at 105,754,852 bp
  • A to T, chromosome 7 at 118,509,907 bp
  • C to G, chromosome 7 at 134,293,328 bp
  • G to A, chromosome 7 at 139,660,082 bp
  • T to C, chromosome 8 at 102,673,962 bp
  • T to C, chromosome 8 at 104,215,154 bp
  • T to C, chromosome 9 at 3,000,937 bp
  • C to T, chromosome 9 at 105,698,949 bp
  • T to C, chromosome 10 at 62,468,345 bp
  • T to C, chromosome 11 at 61,344,513 bp
  • C to T, chromosome 11 at 73,777,040 bp
  • T to C, chromosome 11 at 98,095,235 bp
  • C to T, chromosome 13 at 20,282,914 bp
  • A to T, chromosome 14 at 8,536,609 bp
  • A to T, chromosome 14 at 65,547,877 bp
  • A to T, chromosome 15 at 75,910,515 bp
  • A to T, chromosome 15 at 90,971,142 bp
  • A to G, chromosome 15 at 102,323,236 bp
  • G to A, chromosome 16 at 13,838,346 bp
  • T to A, chromosome 16 at 44,473,864 bp
  • T to A, chromosome 18 at 12,495,358 bp
  • A to G, chromosome 18 at 74,625,674 bp
  • G to A, chromosome 18 at 80,211,576 bp
  • A to G, chromosome 19 at 29,570,765 bp
  • T to C, chromosome 19 at 43,504,841 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4516 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041760-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.