Strain Name:
C57BL/6J-MtgxR4564Btlr/Mmmh
Stock Number:
041789-MU
Citation ID:
RRID:MMRRC_041789-MU
Other Names:
R4564 (G1), C57BL/6J-MtgxR4564Btlr
Major Collection:

Gene Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: Dicer1, D12Ertd7e, 1110006F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74315
Homologene: 14427
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20467
Homologene: 81810
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: 9430080K19Rik, Nik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239667
Homologene: 72227
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57908
Homologene: 22808
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: FBP, Fubp, 9530027K12Rik, Fubp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: E130202I16Rik, GAT4, Gabt4, Gat3, D930045G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243616
Homologene: 129935
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: Nobq1, 1110062G02Rik, Nob1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57915
Homologene: 56856
Upf2
Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 326622
Homologene: 6101
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: lcsd, nmf164, D18Ertd723e, A430089E03Rik, D18Ertd139e, C85354
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Atad3a
Name: ATPase family, AAA domain containing 3A
Synonyms: 2400004H09Rik, Tob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108888
Homologene: 10059
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Mcm6
Name: minichromosome maintenance complex component 6
Synonyms: D1Wsu22e, Mcmd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17219
HGNC: HGNC:6949
Homologene: 4322
Zfp346
Name: zinc finger protein 346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26919
Homologene: 8073
Riok3
Name: RIO kinase 3
Synonyms: Sudd, 1200013N13Rik, E130306C24Rik, D18Ertd331e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66878
VEGA: 18
Homologene: 2843
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Cnot3
Name: CCR4-NOT transcription complex, subunit 3
Synonyms: A930039N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232791
HGNC: HGNC:7879
Homologene: 133900
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Ppil3
Name: peptidylprolyl isomerase (cyclophilin)-like 3
Synonyms: Cyp10l, 2310076N22Rik, 2510026K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70225
HGNC: HGNC:9262
Homologene: 41717
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Vmn1r78
Name: vomeronasal 1 receptor 78
Synonyms: V1rg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171242
Homologene: 74316
Speg
Name: SPEG complex locus
Synonyms: SPEG, Apeg1, BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, MX, 1700052O22Rik, 4931438M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Fpr-rs6
Name: formyl peptide receptor, related sequence 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 321020
Homologene: 104303
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239833
Homologene: 13198
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74485
Homologene: 83646
Niban3
Name: niban apoptosis regulator 3
Synonyms: Fam129c, Bcnp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100037278
Homologene: 45462
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320640
Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Synonyms: Oct2, Orct2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20518
VEGA: 17
Homologene: 68293
St6gal2
Name: beta galactoside alpha 2,6 sialyltransferase 2
Synonyms: ST6Gal II, C230064G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240119
Homologene: 13052
Olfr1311
Name: olfactory receptor 1311
Synonyms: GA_x6K02T2Q125-73069292-73068354, MOR245-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258271
Homologene: 133656
Pgap6
Name: post-glycosylphosphatidylinositol attachment to proteins 6
Synonyms: M83, Tmem8, Rxylt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 60455
Homologene: 10944
Olfml2a
Name: olfactomedin-like 2A
Synonyms: 4932431K08Rik, photomedin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241327
Homologene: 35248
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Mn1
Name: meningioma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433938
HGNC: HGNC:7180
Homologene: 37620
Prr5l
Name: proline rich 5 like
Synonyms: 2600010E01Rik, 4833411O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72446
Homologene: 11753
Upk1b
Name: uroplakin 1B
Synonyms: Tspan20, Upk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22268
VEGA: 16
Homologene: 5065
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: IP, prostacyclin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Npas2
Name: neuronal PAS domain protein 2
Synonyms: MOP4, bHLHe9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Gm10770
Name: predicted gene 10770
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 544945
VEGA: 2
Gm826
Name: predicted gene 826
Synonyms: LOC329554
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329554
Tlcd3a
Name: TLC domain containing 3A
Synonyms: 4932415L08Rik, 5430402E13Rik, Wdt3, 2310047D13Rik, Fam57a, 5430420K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 116972
Homologene: 11720
Bach2os
Name: BTB and CNC homology 2, opposite strand
Synonyms: BC024582
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 414068
Ccl19
Name: chemokine (C-C motif) ligand 19
Synonyms: exodus-3, CKb11, Scya19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24047
Homologene: 4569
Prr23a3
Name: proline rich 23A, member 3
Synonyms: 2410012M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71979
Homologene: 67036
Gm16277
Name: predicted gene 16277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,287,566 bp
  • A to G, chromosome 1 at 39,988,975 bp
  • T to A, chromosome 1 at 58,431,322 bp
  • A to C, chromosome 1 at 75,391,834 bp
  • C to T, chromosome 1 at 128,221,659 bp
  • G to T, chromosome 1 at 128,343,459 bp
  • A to C, chromosome 2 at 6,027,312 bp
  • C to T, chromosome 2 at 38,960,294 bp
  • G to A, chromosome 2 at 57,307,083 bp
  • T to C, chromosome 2 at 101,746,749 bp
  • A to G, chromosome 2 at 112,021,767 bp
  • T to C, chromosome 2 at 150,178,911 bp
  • A to C, chromosome 2 at 160,311,993 bp
  • T to A, chromosome 3 at 87,745,408 bp
  • C to A, chromosome 3 at 152,222,936 bp
  • T to G, chromosome 4 at 32,563,338 bp
  • G to T, chromosome 4 at 42,756,295 bp
  • C to T, chromosome 4 at 112,119,869 bp
  • C to T, chromosome 4 at 155,747,309 bp
  • A to G, chromosome 5 at 64,173,484 bp
  • C to G, chromosome 5 at 111,420,667 bp
  • T to C, chromosome 5 at 121,350,431 bp
  • G to T, chromosome 6 at 114,131,362 bp
  • G to A, chromosome 7 at 3,653,258 bp
  • A to T, chromosome 7 at 12,152,558 bp
  • A to G, chromosome 7 at 16,906,869 bp
  • T to A, chromosome 7 at 80,368,838 bp
  • T to C, chromosome 8 at 71,605,060 bp
  • A to C, chromosome 8 at 72,753,581 bp
  • A to G, chromosome 9 at 44,361,597 bp
  • A to G, chromosome 9 at 98,865,137 bp
  • C to T, chromosome 9 at 109,113,420 bp
  • T to C, chromosome 10 at 92,839,540 bp
  • A to G, chromosome 11 at 44,548,808 bp
  • T to A, chromosome 11 at 76,212,455 bp
  • A to G, chromosome 12 at 51,633,621 bp
  • T to A, chromosome 12 at 104,704,751 bp
  • T to A, chromosome 12 at 110,954,785 bp
  • A to C, chromosome 13 at 55,113,707 bp
  • G to A, chromosome 13 at 91,885,654 bp
  • G to A, chromosome 15 at 100,157,258 bp
  • A to G, chromosome 16 at 33,109,856 bp
  • T to A, chromosome 16 at 38,780,107 bp
  • A to G, chromosome 17 at 12,610,056 bp
  • A to T, chromosome 17 at 20,182,906 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to G, chromosome 17 at 26,117,863 bp
  • T to A, chromosome 17 at 46,412,815 bp
  • T to A, chromosome 17 at 55,482,647 bp
  • A to G, chromosome 17 at 87,712,632 bp
  • C to A, chromosome 18 at 12,148,879 bp
  • C to T, chromosome 18 at 12,191,732 bp
  • T to A, chromosome 18 at 84,622,286 bp
  • T to C, chromosome 19 at 18,832,597 bp
  • T to C, chromosome 19 at 58,239,250 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4564 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041789-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.