Strain Name:
C57BL/6J-MtgxR4753Btlr/Mmmh
Stock Number:
041971-MU
Citation ID:
RRID:MMRRC_041971-MU
Other Names:
R4753 (G1), C57BL/6J-MtgxR4753Btlr
Major Collection:

Gene Information

Slc6a12
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms: Gabt2, BGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14411
Homologene: 128225
Foxm1
Name: forkhead box M1
Synonyms: Foxm1b, Fkh16, Trident, HFH-11B, Mpm2, WIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14235
HGNC: HGNC:3818
Homologene: 7318
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Srsf16, Sfrs16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53609
Homologene: 134306
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269424
Homologene: 18162
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319493
Homologene: 32254
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: D17Wsu134e, p90rsk, Rsk3, 90kDa, pp90rsk, Rps6ka-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Cdk13
Name: cyclin-dependent kinase 13
Synonyms: 2310015O17Rik, Cdc2l5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21853
Homologene: 31206
Sik3
Name: SIK family kinase 3
Synonyms: 9030204A07Rik, 5730525O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70661
Homologene: 57023
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, Bat2l2, 1810043M20Rik, Bat2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 5730564G15Rik, 2810047L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76843
Homologene: 32313
E130114P18Rik
Name: RIKEN cDNA E130114P18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319865
Rasa1
Name: RAS p21 protein activator 1
Synonyms: Gap, p120-rasGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Rad52
Name: RAD52 homolog, DNA repair protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19365
HGNC: HGNC:9824
Homologene: 31118
Cntrl
Name: centriolin
Synonyms: Cep110, IB3/5, Ma2a8, Cep1, b2b1468Clo, 6720467O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Fign
Name: fidgetin
Synonyms: Fgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 60344
Homologene: 5813
Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms: p52, NF kappaB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18034
VEGA: 19
HGNC: HGNC:7795
Homologene: 1873
Muc19
Name: mucin 19
Synonyms: sld, apomucin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239611
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22324
Homologene: 3961
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 332221
Homologene: 13122
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: Polydom, 1110021D17Rik, D430029O09Rik, 4833413O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Lama3
Name: laminin, alpha 3
Synonyms: [a]3B, nicein, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Clrn1
Name: clarin 1
Synonyms: A130002D11Rik, Ush3a, USH3, clarin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229320
Homologene: 17738
Olfr395
Name: olfactory receptor 395
Synonyms: MOR135-10, GA_x6K02T2P1NL-4062605-4061667
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259007
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66873
Homologene: 69404
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 2010200K21Rik, 4833414G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75767
Homologene: 11853
Tnxb
Name: tenascin XB
Synonyms: TN-MHC, Tnx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Dus1l
Name: dihydrouridine synthase 1-like (S. cerevisiae)
Synonyms: 1110032N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68730
Homologene: 6569
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Cyld
Name: CYLD lysine 63 deubiquitinase
Synonyms: 2010013M14Rik, C130039D01Rik, 2900009M21Rik, CYLD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74256
HGNC: HGNC:2584
Homologene: 9069
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2210420P05Rik, 2600014C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70297
Homologene: 45639
Cd48
Name: CD48 antigen
Synonyms: BCM1, Sgp-60, Bcm-1, BLAST-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Fam83g
Name: family with sequence similarity 83, member G
Synonyms: wly, 2310040C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69640
Homologene: 85169
Stk36
Name: serine/threonine kinase 36
Synonyms: Fused, 1700112N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269209
Homologene: 49432
Masp2
Name: mannan-binding lectin serine peptidase 2
Synonyms: MASP-2, MAp19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Rph3al
Name: rabphilin 3A-like (without C2 domains)
Synonyms: Noc2, 6530413F01Rik, LOC385671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380714
Homologene: 5078
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320640
Mill1
Name: MHC I like leukocyte 1
Synonyms: 5530400I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 266815
Homologene: 105329
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208967
Homologene: 32609
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: GluRepsilon4, NR2D, GluN2D, NMDAR2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Olfr1377
Name: olfactory receptor 1377
Synonyms: MOR129-1, GA_x6K02T2QP88-4453480-4452557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258913
Homologene: 64929
Rogdi
Name: rogdi homolog
Synonyms: 0610011C19Rik, Lzf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66049
Homologene: 11605
Ighv1-43
Name: immunoglobulin heavy variable V1-43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629908
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: 2310005K03Rik, G4.8, Dnase1ll, Dnl1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Procr
Name: protein C receptor, endothelial
Synonyms: Ccca, EPCR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19124
HGNC: HGNC:9452
Homologene: 4670
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,626,096 bp
  • A to G, chromosome 1 at 162,691,230 bp
  • A to G, chromosome 1 at 171,699,588 bp
  • T to C, chromosome 1 at 191,569,703 bp
  • C to T, chromosome 2 at 21,213,364 bp
  • T to A, chromosome 2 at 35,153,439 bp
  • T to A, chromosome 2 at 63,979,019 bp
  • A to G, chromosome 2 at 155,753,464 bp
  • C to T, chromosome 3 at 41,596,671 bp
  • G to T, chromosome 3 at 58,884,897 bp
  • C to T, chromosome 4 at 43,372,710 bp
  • T to C, chromosome 4 at 58,053,212 bp
  • A to T, chromosome 4 at 97,574,892 bp
  • A to G, chromosome 4 at 112,146,531 bp
  • A to G, chromosome 4 at 148,612,151 bp
  • T to C, chromosome 5 at 115,616,478 bp
  • A to G, chromosome 6 at 53,819,713 bp
  • T to A, chromosome 6 at 119,912,985 bp
  • C to T, chromosome 6 at 121,356,903 bp
  • A to G, chromosome 6 at 128,372,556 bp
  • A to C, chromosome 7 at 18,262,547 bp
  • A to T, chromosome 7 at 19,594,940 bp
  • G to T, chromosome 7 at 45,833,906 bp
  • A to G, chromosome 7 at 128,223,703 bp
  • C to A, chromosome 7 at 141,856,853 bp
  • T to C, chromosome 8 at 3,444,938 bp
  • T to C, chromosome 8 at 27,152,741 bp
  • T to A, chromosome 8 at 87,781,446 bp
  • T to A, chromosome 8 at 88,744,816 bp
  • T to C, chromosome 9 at 46,198,214 bp
  • T to C, chromosome 10 at 58,290,382 bp
  • G to A, chromosome 10 at 128,240,020 bp
  • T to C, chromosome 11 at 50,985,151 bp
  • C to A, chromosome 11 at 61,695,269 bp
  • T to A, chromosome 11 at 73,906,851 bp
  • G to A, chromosome 11 at 75,909,019 bp
  • C to T, chromosome 11 at 120,792,075 bp
  • C to A, chromosome 12 at 114,946,142 bp
  • G to A, chromosome 13 at 17,763,248 bp
  • A to G, chromosome 13 at 85,288,390 bp
  • T to A, chromosome 13 at 112,363,475 bp
  • T to G, chromosome 15 at 91,877,761 bp
  • T to C, chromosome 16 at 5,010,499 bp
  • T to C, chromosome 16 at 21,892,002 bp
  • T to A, chromosome 17 at 7,299,308 bp
  • A to C, chromosome 17 at 23,607,234 bp
  • G to A, chromosome 17 at 34,695,935 bp
  • A to G, chromosome 17 at 57,306,140 bp
  • G to T, chromosome 18 at 12,482,084 bp
  • A to T, chromosome 18 at 25,090,325 bp
  • G to T, chromosome 19 at 46,307,567 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4753 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041971-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.