Strain Name:
C57BL/6J-MtgxR4523Btlr/Mmmh
Stock Number:
042004-MU
Citation ID:
RRID:MMRRC_042004-MU
Other Names:
R4523 (G1), C57BL/6J-MtgxR4523Btlr
Major Collection:

Gene Information

Calb2
Name: calbindin 2
Synonyms: CR, calretinin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12308
HGNC: HGNC:1435
Homologene: 1318
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2810470K03Rik, 2600016M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Pard3
Name: par-3 family cell polarity regulator
Synonyms: Pard3a, Par3, PAR-3, D8Ertd580e, ASIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93742
Homologene: 10489
Dido1
Name: death inducer-obliterator 1
Synonyms: C130092D22Rik, dido, DIO-1, 6720461J16Rik, D130048F08Rik, Datf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Orc4
Name: origin recognition complex, subunit 4
Synonyms: Orc4, Orc4l, Orc4P, mMmORC4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Prr12
Name: proline rich 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233210
Homologene: 18957
Tjap1
Name: tight junction associated protein 1
Synonyms: 0610041D19Rik, Pilt, Tjp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74094
VEGA: 17
Homologene: 12534
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269470
Homologene: 4937
Dusp5
Name: dual specificity phosphatase 5
Synonyms: LOC240672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240672
HGNC: HGNC:3071
Homologene: 3256
Xdh
Name: xanthine dehydrogenase
Synonyms: Xor, Xox1, XO, xanthine oxidase, Xox-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Nectin3
Name: nectin cell adhesion molecule 3
Synonyms: 2610301B19Rik, Pvrl3, nectin-3, 3000002N23Rik, 4921513D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 58998
Homologene: 9162
Sh3glb2
Name: SH3-domain GRB2-like endophilin B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227700
Homologene: 10595
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231128
Homologene: 2746
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Pcmt1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Synonyms: PIMT, protein carboxyl methyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18537
HGNC: HGNC:8728
Homologene: 135759
Nop2
Name: NOP2 nucleolar protein
Synonyms: Nol1, 120kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Rpl10l
Name: ribosomal protein L10-like
Synonyms: EG238217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238217
Homologene: 68830
Olfml2b
Name: olfactomedin-like 2B
Synonyms: 4832415H08Rik, photomedin-2, 1110018N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320078
Homologene: 18546
Plcd4
Name: phospholipase C, delta 4
Synonyms: 4921507K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18802
HGNC: HGNC:9062
Homologene: 88782
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: 9430010M12Rik, Tmem76, D8Ertd354e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52120
Homologene: 15586
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: LOC380889, HL-19, DHC3, 4921531P07Rik, Dnahc12, HL19, Hdhc3, Dnahc7l, DLP12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Slc5a4a
Name: solute carrier family 5, member 4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64452
VEGA: 10
Fmo2
Name: flavin containing monooxygenase 2
Synonyms: 2310008D08Rik, 2310042I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 55990
HGNC: HGNC:3770
Homologene: 86882
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78796
Homologene: 14632
Tgm7
Name: transglutaminase 7
Synonyms: TGz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 640543
Homologene: 14192
Prkce
Name: protein kinase C, epsilon
Synonyms: 5830406C15Rik, Pkce, PKCepsilon, PKC[e]
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Cstf2t
Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms: 64kDa, tCstF-64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83410
VEGA: 19
Homologene: 80230
Ubqlnl
Name: ubiquilin-like
Synonyms: LOC244179, 4922504M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244179
Homologene: 17034
Ptprn2
Name: protein tyrosine phosphatase, receptor type, N polypeptide 2
Synonyms: IA-2 beta, PTP-NP, 4930425H11Rik, phogrin, IA-2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Fam126a
Name: family with sequence similarity 126, member A
Synonyms: hyccin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 84652
Homologene: 57175
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: Vmn2r72-ps, EG244114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244114
Homologene: 115466
Fbxo41
Name: F-box protein 41
Synonyms: D6Ertd538e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330369
Homologene: 19837
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Atp8a1
Name: ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Synonyms: B230107D19Rik, Atp3a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11980
Homologene: 48402
Tsr3
Name: TSR3 20S rRNA accumulation
Synonyms: 1110014B11Rik, 0610007P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68327
VEGA: 17
Homologene: 6922
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Rnf144b
Name: ring finger protein 144B
Synonyms: E130105P19Rik, Ibrdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218215
VEGA: 13
Homologene: 27092
Map3k3
Name: mitogen-activated protein kinase kinase kinase 3
Synonyms: Mekk3, MAPKKK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26406
HGNC: HGNC:6855
Homologene: 69110
Olfr843
Name: olfactory receptor 843
Synonyms: MOR155-2, GA_x6K02T2PVTD-12986331-12985390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258560
Homologene: 74251
Cdca7
Name: cell division cycle associated 7
Synonyms: JPO1, 2310021G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66953
Homologene: 49970
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627367
Homologene: 115024
1700028K03Rik
Name: RIKEN cDNA 1700028K03 gene
Synonyms: SCRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76421
Homologene: 18810
Olfr1054
Name: olfactory receptor 1054
Synonyms: GA_x6K02T2Q125-47811880-47810942, MOR188-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259021
Homologene: 133882
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74129
Homologene: 8372
Cybc1
Name: cytochrome b 245 chaperone 1
Synonyms: BC017643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217370
Homologene: 51645
Optc
Name: opticin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Gm7173
Name: predicted gene 7173
Synonyms:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Tepp
Name: testis, prostate and placenta expressed
Synonyms: 1700055M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73407
Homologene: 28311
Fam122c
Name: family with sequence similarity 122, member C
Synonyms: 4930432H15Rik, 4930527G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73866
Homologene: 87062
Gm5277
Name: predicted gene 5277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 383883
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 74,560,406 bp
  • G to T, chromosome 1 at 133,903,754 bp
  • T to C, chromosome 1 at 162,887,708 bp
  • T to C, chromosome 1 at 170,669,222 bp
  • A to T, chromosome 2 at 30,350,699 bp
  • G to A, chromosome 2 at 48,937,489 bp
  • A to G, chromosome 2 at 72,479,698 bp
  • C to G, chromosome 2 at 86,333,300 bp
  • C to A, chromosome 2 at 121,098,588 bp
  • T to C, chromosome 2 at 180,672,292 bp
  • G to T, chromosome 3 at 78,892,186 bp
  • G to A, chromosome 3 at 100,151,040 bp
  • A to G, chromosome 3 at 109,934,996 bp
  • A to G, chromosome 5 at 14,679,992 bp
  • T to C, chromosome 5 at 23,965,122 bp
  • G to A, chromosome 5 at 34,443,371 bp
  • A to G, chromosome 5 at 52,784,067 bp
  • G to T, chromosome 5 at 67,667,600 bp
  • A to G, chromosome 5 at 107,548,203 bp
  • G to T, chromosome 5 at 108,576,566 bp
  • A to G, chromosome 6 at 85,484,042 bp
  • G to T, chromosome 6 at 125,133,552 bp
  • T to C, chromosome 7 at 45,048,523 bp
  • T to A, chromosome 7 at 85,751,926 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • T to C, chromosome 7 at 110,923,841 bp
  • A to G, chromosome 8 at 25,968,361 bp
  • T to A, chromosome 8 at 95,313,010 bp
  • C to T, chromosome 8 at 110,148,509 bp
  • C to T, chromosome 8 at 125,492,424 bp
  • C to T, chromosome 8 at 127,398,627 bp
  • T to C, chromosome 9 at 19,249,229 bp
  • T to C, chromosome 9 at 95,862,863 bp
  • T to C, chromosome 10 at 7,640,771 bp
  • A to T, chromosome 10 at 28,466,052 bp
  • C to T, chromosome 10 at 76,148,362 bp
  • C to T, chromosome 10 at 116,581,474 bp
  • G to A, chromosome 11 at 106,148,868 bp
  • A to G, chromosome 11 at 121,224,108 bp
  • T to C, chromosome 12 at 66,283,738 bp
  • G to T, chromosome 12 at 100,913,332 bp
  • T to C, chromosome 12 at 116,876,000 bp
  • T to C, chromosome 13 at 47,207,537 bp
  • C to T, chromosome 13 at 93,688,630 bp
  • T to C, chromosome 14 at 26,770,022 bp
  • G to A, chromosome 14 at 26,876,958 bp
  • T to C, chromosome 16 at 32,736,336 bp
  • C to A, chromosome 16 at 46,448,590 bp
  • T to A, chromosome 17 at 18,929,071 bp
  • C to G, chromosome 17 at 25,241,749 bp
  • T to C, chromosome 17 at 25,828,291 bp
  • A to G, chromosome 17 at 46,258,792 bp
  • C to A, chromosome 17 at 73,898,344 bp
  • G to T, chromosome 17 at 86,490,750 bp
  • G to T, chromosome 18 at 37,520,421 bp
  • A to T, chromosome 19 at 18,796,500 bp
  • T to A, chromosome 19 at 31,083,082 bp
  • T to G, chromosome 19 at 53,537,601 bp
  • G to A, chromosome X at 53,293,499 bp
  • A to T, chromosome X at 79,509,995 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4523 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042004-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.