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Strain Name:
C57BL/6J-MtgxR4737Btlr/Mmmh
Stock Number:
042024-MU
Citation ID:
RRID:MMRRC_042024-MU
Other Names:
R4737 (G1), C57BL/6J-MtgxR4737Btlr
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: Crfr2, CRF-R2, CRFR2beta, CRFR2alpha, CRF 2 receptor, CRH-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Chrna9
Name: cholinergic receptor, nicotinic, alpha polypeptide 9
Synonyms: Acra9, 2410015I05Rik, Gm8311
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231252
Homologene: 9729
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69207
Homologene: 36164
Zbtb7c
Name: zinc finger and BTB domain containing 7C
Synonyms: B230208J24Rik, Zbtb36, Kr-pok
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 207259
VEGA: 18
Homologene: 17070
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,189,611 bp
  • G to A, chromosome 1 at 39,402,878 bp
  • A to G, chromosome 1 at 60,109,318 bp
  • T to C, chromosome 1 at 68,343,900 bp
  • A to G, chromosome 1 at 72,004,552 bp
  • T to C, chromosome 1 at 90,077,822 bp
  • C to T, chromosome 1 at 132,603,804 bp
  • T to G, chromosome 1 at 150,689,595 bp
  • T to C, chromosome 1 at 158,957,012 bp
  • T to G, chromosome 1 at 160,146,089 bp
  • A to G, chromosome 1 at 181,227,819 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to C, chromosome 2 at 87,372,321 bp
  • C to T, chromosome 2 at 88,526,225 bp
  • C to T, chromosome 2 at 89,406,486 bp
  • A to G, chromosome 2 at 90,282,381 bp
  • A to T, chromosome 2 at 91,210,723 bp
  • T to C, chromosome 2 at 120,266,790 bp
  • T to A, chromosome 2 at 122,125,306 bp
  • A to T, chromosome 2 at 146,222,902 bp
  • A to G, chromosome 2 at 158,628,071 bp
  • A to G, chromosome 2 at 163,564,219 bp
  • A to G, chromosome 2 at 167,029,299 bp
  • T to C, chromosome 3 at 64,409,963 bp
  • A to T, chromosome 3 at 89,168,709 bp
  • C to T, chromosome 3 at 95,004,338 bp
  • T to C, chromosome 3 at 116,539,132 bp
  • A to T, chromosome 3 at 158,026,732 bp
  • T to C, chromosome 4 at 43,540,588 bp
  • C to T, chromosome 4 at 99,831,568 bp
  • G to A, chromosome 4 at 129,555,984 bp
  • G to A, chromosome 4 at 138,735,948 bp
  • G to A, chromosome 5 at 35,961,782 bp
  • A to T, chromosome 5 at 65,967,871 bp
  • A to T, chromosome 5 at 66,365,070 bp
  • T to A, chromosome 5 at 149,194,339 bp
  • G to A, chromosome 5 at 150,661,533 bp
  • T to C, chromosome 6 at 17,491,541 bp
  • T to A, chromosome 6 at 18,299,883 bp
  • A to T, chromosome 6 at 31,426,799 bp
  • G to C, chromosome 6 at 39,152,839 bp
  • A to T, chromosome 6 at 45,060,317 bp
  • T to C, chromosome 6 at 47,962,542 bp
  • G to T, chromosome 6 at 55,091,305 bp
  • T to C, chromosome 6 at 66,553,645 bp
  • T to A, chromosome 6 at 120,406,015 bp
  • A to T, chromosome 7 at 35,703,501 bp
  • C to T, chromosome 7 at 66,306,873 bp
  • C to T, chromosome 7 at 103,085,914 bp
  • T to A, chromosome 7 at 118,724,548 bp
  • T to C, chromosome 7 at 127,780,402 bp
  • G to T, chromosome 7 at 141,638,772 bp
  • T to G, chromosome 7 at 141,640,159 bp
  • T to A, chromosome 8 at 84,249,521 bp
  • A to T, chromosome 9 at 40,000,422 bp
  • A to G, chromosome 9 at 78,150,654 bp
  • A to G, chromosome 9 at 108,080,521 bp
  • A to G, chromosome 9 at 118,049,974 bp
  • G to A, chromosome 9 at 121,073,872 bp
  • T to A, chromosome 10 at 69,279,497 bp
  • T to C, chromosome 10 at 91,122,188 bp
  • T to A, chromosome 10 at 130,162,838 bp
  • T to A, chromosome 11 at 6,297,044 bp
  • T to C, chromosome 11 at 16,869,231 bp
  • T to A, chromosome 11 at 67,855,505 bp
  • A to T, chromosome 11 at 69,678,829 bp
  • T to C, chromosome 11 at 82,787,727 bp
  • T to C, chromosome 11 at 97,148,648 bp
  • G to A, chromosome 12 at 18,216,772 bp
  • A to T, chromosome 12 at 52,519,077 bp
  • T to C, chromosome 12 at 98,708,844 bp
  • C to T, chromosome 12 at 98,798,852 bp
  • T to A, chromosome 12 at 103,392,844 bp
  • T to A, chromosome 14 at 12,226,314 bp
  • A to T, chromosome 14 at 45,628,821 bp
  • T to A, chromosome 14 at 103,572,037 bp
  • C to T, chromosome 15 at 89,421,406 bp
  • C to T, chromosome 16 at 18,251,286 bp
  • T to G, chromosome 16 at 20,659,815 bp
  • A to T, chromosome 17 at 25,781,309 bp
  • G to T, chromosome 17 at 36,640,739 bp
  • A to C, chromosome 17 at 56,198,970 bp
  • T to C, chromosome 17 at 56,767,868 bp
  • C to T, chromosome 17 at 84,563,959 bp
  • T to C, chromosome 18 at 15,452,777 bp
  • T to C, chromosome 18 at 31,998,602 bp
  • C to T, chromosome 18 at 37,145,899 bp
  • T to C, chromosome 18 at 64,516,427 bp
  • G to T, chromosome 18 at 76,146,154 bp
  • A to G, chromosome 19 at 4,170,928 bp
  • A to G, chromosome 19 at 7,281,232 bp
  • A to G, chromosome 19 at 10,650,579 bp
  • T to A, chromosome 19 at 34,501,634 bp
  • T to A, chromosome 19 at 43,691,195 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4737 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042024-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.