Strain Name:
Stock Number:
Citation ID:
Other Names:
Atoh7-tm1Gla, Atoh7 KO, Atoh7-lacZ, MAth5 KO

Gene Information

Name: atonal bHLH transcription factor 7; targeted mutation 1, Tom Glaser
Synonyms: Math5-lacZ, Math5-
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Knockout
Name: atonal bHLH transcription factor 7
Synonyms: bHLHa13, Math5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Knockout
NCBI: 53404
VEGA: 10
Homologene: 32338
Genetic Alterations
A targeted internal deletion in ES cells of a 256 bp coding region with an insertion of PGK-neo-pA cassette between SmaI sites and an in-frame insertion of cytoplasmic lacZ-pA starting at codon 19.
ES Cell Line
R1 Derived From (129X1/SvJ x 129S1/Sv)F1-Kitl+

Homozygous: > absent retinal ganglion cells and optic nerves [MP: 0001330, 0001333, 0009772] > absent circadian photoentrainment [MP: 00013912] > abnormal ERGs with reduced a- and b-wave amplitudes [MP: 0012144, 0012143] > secondary neuroretinal dysgenesis (histology, rosettes, thinned ONL and INL) [MP: 0002864] > secondary retinal astrocyte and vascular defects [MP: 0010098, 0006185, 0012537, 000128, 0010098, 0008852]

Hetero/Hemizygous: > essentially wild-type > quantitative difference in RGC number at birth (RGC genesis), which is corrected during the normal period of neonatal culling, which eliminates excess RGCs that do not synapse productively in the brain (P0-P10)

Cre-excised Phenotype: undetermined 

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

Strain Development
> knockout in vitro in R1 ES cells with G418 selection (1999-2000) > generation of ES C57BL/6J chimeric founders > germline transmission by crossing to C57 mice > serial backcrossing to C57BL/6J for >N20 generations, with PCR genotyping at each generation > intercrossing KO/+ mice to obtain male and female N20F2 homozygotes (2017) > maintenance of homozygous KO congenic stock (now at N20F3)
Suggested Control Mice
Wild-type littermates
  • Cell Biology
  • Developmental Biology
  • Models for Human Disease
  • Neurobiology
  • Research Tools
  • Sensorineural
Tom Glaser, M.D., Ph.D., University of California, Davis.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
Coat Color
MMRRC Breeding System
Overall Breeding Performance
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: 8 to 12 months 8 to 12 months
Average litter size
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042298-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / $1,549.67
Non-Profit / For-Profit
Aliquot Approximate quantity3 : 20-40 embryos / aliquot
042298-UCD-SPERM Cryo-preserved spermatozoa $546.25 / $871.90
Non-Profit / For-Profit
Aliquot Approximate quantity2
042298-UCD-RESUS Litter recovered from cryo-archive $3,033.00 / $6,017.01
Non-Profit / For-Profit
Litter Recovered litter1; additional fees for any special requests.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.