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Strain Name:
C57BL/6J-MtgxR4798Btlr/Mmmh
Stock Number:
042422-MU
Citation ID:
RRID:MMRRC_042422-MU
Other Names:
R4798 (G1), C57BL/6J-MtgxR4798Btlr
Major Collection:

Strain Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Dennd2b
Name: DENN domain containing 2B
Synonyms: 2610305K15Rik, 2010004M01Rik, St5, Denn2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76954
Homologene: 3951
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Sgpl1
Name: sphingosine phosphate lyase 1
Synonyms: D10Xrf456
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20397
Homologene: 2897
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Rad51c
Name: RAD51 paralog C
Synonyms: Rad51l2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114714
HGNC: HGNC:9820
Homologene: 14238
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 37,624,965 bp
  • T to G, chromosome 1 at 60,222,193 bp
  • A to T, chromosome 1 at 106,712,608 bp
  • A to T, chromosome 1 at 139,891,658 bp
  • T to C, chromosome 1 at 158,857,379 bp
  • T to C, chromosome 1 at 188,743,545 bp
  • A to G, chromosome 2 at 21,783,182 bp
  • T to C, chromosome 2 at 25,458,182 bp
  • A to T, chromosome 2 at 69,691,307 bp
  • C to T, chromosome 2 at 104,214,249 bp
  • T to C, chromosome 2 at 120,059,141 bp
  • C to T, chromosome 2 at 127,829,707 bp
  • C to T, chromosome 2 at 148,875,174 bp
  • G to A, chromosome 2 at 150,959,881 bp
  • T to C, chromosome 2 at 167,038,569 bp
  • C to T, chromosome 3 at 33,813,155 bp
  • A to G, chromosome 3 at 35,985,001 bp
  • G to A, chromosome 3 at 90,020,903 bp
  • T to C, chromosome 3 at 94,943,900 bp
  • C to T, chromosome 3 at 129,716,678 bp
  • T to C, chromosome 4 at 41,766,096 bp
  • T to G, chromosome 4 at 46,991,139 bp
  • A to G, chromosome 4 at 53,744,637 bp
  • T to A, chromosome 4 at 80,911,413 bp
  • T to C, chromosome 4 at 94,965,673 bp
  • C to G, chromosome 4 at 96,002,557 bp
  • G to A, chromosome 4 at 103,130,998 bp
  • G to A, chromosome 4 at 106,360,162 bp
  • A to G, chromosome 4 at 123,000,256 bp
  • T to A, chromosome 4 at 123,190,698 bp
  • A to C, chromosome 4 at 145,178,056 bp
  • C to A, chromosome 4 at 150,615,167 bp
  • C to T, chromosome 5 at 31,189,520 bp
  • G to T, chromosome 5 at 31,241,085 bp
  • T to A, chromosome 5 at 38,227,886 bp
  • G to A, chromosome 5 at 90,260,054 bp
  • T to A, chromosome 5 at 108,703,497 bp
  • A to G, chromosome 5 at 142,485,163 bp
  • A to T, chromosome 6 at 57,604,166 bp
  • T to C, chromosome 6 at 89,869,910 bp
  • A to G, chromosome 6 at 91,269,186 bp
  • G to A, chromosome 6 at 118,630,302 bp
  • A to G, chromosome 6 at 132,893,707 bp
  • T to G, chromosome 7 at 98,499,017 bp
  • C to T, chromosome 7 at 109,557,033 bp
  • T to C, chromosome 7 at 118,180,474 bp
  • C to A, chromosome 7 at 141,754,140 bp
  • C to T, chromosome 7 at 142,439,945 bp
  • G to A, chromosome 8 at 41,293,678 bp
  • T to A, chromosome 8 at 99,024,926 bp
  • T to A, chromosome 9 at 20,471,014 bp
  • C to T, chromosome 9 at 22,011,738 bp
  • T to C, chromosome 9 at 31,341,273 bp
  • T to A, chromosome 9 at 39,819,897 bp
  • C to T, chromosome 9 at 57,141,185 bp
  • A to G, chromosome 9 at 62,776,727 bp
  • A to G, chromosome 9 at 75,388,432 bp
  • A to T, chromosome 9 at 86,783,454 bp
  • A to T, chromosome 10 at 61,123,344 bp
  • A to T, chromosome 10 at 78,800,118 bp
  • A to T, chromosome 10 at 80,323,104 bp
  • A to C, chromosome 10 at 81,643,315 bp
  • A to G, chromosome 10 at 92,698,910 bp
  • A to G, chromosome 10 at 128,047,803 bp
  • T to A, chromosome 11 at 59,069,859 bp
  • T to A, chromosome 11 at 70,650,135 bp
  • T to A, chromosome 11 at 84,828,800 bp
  • T to C, chromosome 11 at 87,395,378 bp
  • C to A, chromosome 11 at 94,433,847 bp
  • T to G, chromosome 11 at 120,711,784 bp
  • T to G, chromosome 11 at 120,881,857 bp
  • A to G, chromosome 12 at 105,652,629 bp
  • G to A, chromosome 12 at 111,678,713 bp
  • A to T, chromosome 12 at 112,916,632 bp
  • G to A, chromosome 13 at 12,412,048 bp
  • T to C, chromosome 13 at 77,323,724 bp
  • T to A, chromosome 13 at 120,318,082 bp
  • A to G, chromosome 14 at 19,789,761 bp
  • A to G, chromosome 14 at 20,693,712 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • T to A, chromosome 14 at 53,795,951 bp
  • T to C, chromosome 14 at 54,953,293 bp
  • T to G, chromosome 14 at 77,111,607 bp
  • A to T, chromosome 15 at 9,461,742 bp
  • T to A, chromosome 15 at 38,689,176 bp
  • A to G, chromosome 15 at 74,626,179 bp
  • C to T, chromosome 15 at 94,540,678 bp
  • C to T, chromosome 15 at 101,550,488 bp
  • A to T, chromosome 16 at 4,492,358 bp
  • T to A, chromosome 16 at 11,420,736 bp
  • G to A, chromosome 16 at 17,803,507 bp
  • T to A, chromosome 16 at 30,341,240 bp
  • A to T, chromosome 16 at 36,722,555 bp
  • T to C, chromosome 16 at 45,825,874 bp
  • T to A, chromosome 16 at 74,352,745 bp
  • T to C, chromosome 16 at 90,757,827 bp
  • G to T, chromosome 17 at 20,570,548 bp
  • A to G, chromosome 17 at 25,860,526 bp
  • G to A, chromosome 17 at 26,961,449 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to A, chromosome 17 at 33,528,752 bp
  • A to T, chromosome 17 at 34,822,509 bp
  • G to A, chromosome 17 at 35,150,042 bp
  • G to A, chromosome 17 at 46,891,219 bp
  • G to T, chromosome 17 at 56,191,016 bp
  • T to A, chromosome 17 at 68,359,480 bp
  • A to G, chromosome 17 at 70,996,302 bp
  • G to T, chromosome 17 at 71,360,053 bp
  • A to G, chromosome 17 at 86,805,839 bp
  • T to C, chromosome 18 at 7,002,432 bp
  • T to C, chromosome 18 at 21,093,254 bp
  • A to G, chromosome 18 at 64,271,749 bp
  • A to T, chromosome 19 at 42,323,801 bp
  • G to T, chromosome 19 at 58,042,361 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4798 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042422-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.