Strain Name:
C57BL/6J-MtgxR4950Btlr/Mmmh
Stock Number:
042547-MU
Citation ID:
RRID:MMRRC_042547-MU
Other Names:
R4950 (G1), C57BL/6J-MtgxR4950Btlr
Major Collection:

Gene Information

Mcoln3
Name: mucolipin 3
Synonyms: varitint-waddler, Va, 6720490O21Rik, TRPML3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 171166
Homologene: 10118
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100502698
Homologene: 15687
Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74351
Homologene: 3542
Mras
Name: muscle and microspikes RAS
Synonyms: 2900078C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17532
HGNC: HGNC:7227
Homologene: 7424
Zfp113
Name: zinc finger protein 113
Synonyms: 4732456B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56314
Homologene: 50027
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: Pck-1, PEPCK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Dph5
Name: diphthamide biosynthesis 5
Synonyms: 2410012M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69740
Homologene: 6471
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 24088
Homologene: 20695
Rarb
Name: retinoic acid receptor, beta
Synonyms: RARbeta2, RAR beta 2, Hap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218772
VEGA: 14
HGNC: HGNC:9865
Homologene: 68100
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Fxyd7
Name: FXYD domain-containing ion transport regulator 7
Synonyms: 1110035I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57780
HGNC: HGNC:4034
Homologene: 11091
Rps9
Name: ribosomal protein S9
Synonyms: 3010033P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76846
Homologene: 68145
Itih5
Name: inter-alpha (globulin) inhibitor H5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209378
Homologene: 57115
Zfp87
Name: zinc finger protein 87
Synonyms: Mzf22, 4631412O18Rik, Zfp72, KRAB4, 2210039O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 170763
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2, 6530411D08Rik, Pwp2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Gpr155
Name: G protein-coupled receptor 155
Synonyms: DEPDC3, PGR22, 1110017O10Rik, F730029F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68526
Homologene: 16584
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Med17
Name: mediator complex subunit 17
Synonyms: C330002H14Rik, Trap80, Crsp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17259
HGNC: HGNC:6995
Homologene: 48381
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70853
Homologene: 27053
Trim17
Name: tripartite motif-containing 17
Synonyms: terf, Rnf16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56631
Homologene: 9387
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211936
Homologene: 52235
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Tbx15
Name: T-box 15
Synonyms: Tbx8, de, Tbx14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21384
Homologene: 7967
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Trim69
Name: tripartite motif-containing 69
Synonyms: 4921519C19Rik, Trif, Rnf36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70928
Homologene: 18827
Pear1
Name: platelet endothelial aggregation receptor 1
Synonyms: 3110045G13Rik, Jedi-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73182
Homologene: 12492
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140579
Homologene: 44338
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Zfp607a
Name: zinc finger protein 607A
Synonyms: 4732475C15Rik, Zfp607
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545938
Homologene: 134321
Spsb3
Name: splA/ryanodine receptor domain and SOCS box containing 3
Synonyms: 2310012N15Rik, 3300001M01Rik, SSB3, Tce1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 79043
Homologene: 12322
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241116
Homologene: 28093
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 80285
Homologene: 12720
Lao1
Name: L-amino acid oxidase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100470
Homologene: 44223
Iho1
Name: interactor of HORMAD1 1
Synonyms: Ccdc36, Iho1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434438
Homologene: 52256
Disp3
Name: dispatched RND transporter family member 3
Synonyms: G630052C06Rik, Ptchd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242748
Homologene: 25712
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Arhgef40
Name: Rho guanine nucleotide exchange factor (GEF) 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268739
Homologene: 19560
Rpain
Name: RPA interacting protein
Synonyms: 2400006N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69723
Homologene: 13006
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: OTTMUSG00000015915, 5430413K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433492
Homologene: 128535
Irx6
Name: Iroquois homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64379
Homologene: 41481
Atg16l2
Name: autophagy related 16-like 2 (S. cerevisiae)
Synonyms: 2410118P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73683
Homologene: 18981
Fez1
Name: fasciculation and elongation protein zeta 1 (zygin I)
Synonyms: UNC-76, UNC76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Slx1b
Name: SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Synonyms: 4833422P03Rik, 2410170E21Rik, 1110030E23Rik, Giyd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75764
Homologene: 11434
Pde6b
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms: Pdeb, rd, r, rd10, rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18587
HGNC: HGNC:8786
Homologene: 237
Ddi1
Name: DNA-damage inducible 1
Synonyms: 1700011N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71829
VEGA: 9
Homologene: 100549
Cage1
Name: cancer antigen 1
Synonyms: CAGE1, 4933427I01Rik, Ctag3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71213
Homologene: 18484
Cxcl15
Name: chemokine (C-X-C motif) ligand 15
Synonyms: weche, lungkine, Scyb15, Il8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20309
Olfr58
Name: olfactory receptor 58
Synonyms: IG6, MOR146-7P, GA_x6K02T2PVTD-13523015-13523944, MOR146-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18358
Homologene: 134093
Dnajc22
Name: DnaJ heat shock protein family (Hsp40) member C22
Synonyms: 2810451A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72778
Homologene: 11777
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237886
Homologene: 45432
Olfr885
Name: olfactory receptor 885
Synonyms: GA_x6K02T2PVTD-31740639-31741568, MOR162-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257885
Homologene: 79400
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,085,332 bp
  • T to A, chromosome 1 at 74,906,336 bp
  • A to C, chromosome 2 at 10,235,081 bp
  • A to G, chromosome 2 at 14,271,280 bp
  • A to T, chromosome 2 at 73,382,185 bp
  • A to T, chromosome 2 at 82,946,932 bp
  • G to A, chromosome 2 at 82,977,414 bp
  • A to C, chromosome 2 at 104,992,366 bp
  • A to G, chromosome 2 at 122,178,746 bp
  • A to T, chromosome 2 at 154,311,659 bp
  • A to T, chromosome 2 at 165,314,813 bp
  • T to A, chromosome 2 at 173,154,827 bp
  • C to A, chromosome 3 at 83,837,332 bp
  • A to G, chromosome 3 at 87,789,611 bp
  • A to G, chromosome 3 at 99,326,384 bp
  • G to A, chromosome 3 at 115,928,643 bp
  • T to C, chromosome 3 at 146,139,519 bp
  • T to A, chromosome 4 at 76,140,515 bp
  • T to C, chromosome 4 at 118,965,375 bp
  • A to T, chromosome 4 at 148,258,126 bp
  • A to T, chromosome 5 at 90,795,245 bp
  • A to G, chromosome 5 at 108,430,703 bp
  • T to C, chromosome 5 at 138,145,472 bp
  • CTGTTTG to CTG, chromosome 7 at 3,704,759 bp
  • A to G, chromosome 7 at 19,092,477 bp
  • T to A, chromosome 7 at 27,878,751 bp
  • G to A, chromosome 7 at 31,047,390 bp
  • T to C, chromosome 7 at 101,291,958 bp
  • T to C, chromosome 7 at 126,691,767 bp
  • T to C, chromosome 8 at 70,167,196 bp
  • A to T, chromosome 8 at 92,678,800 bp
  • C to A, chromosome 8 at 95,248,507 bp
  • A to G, chromosome 9 at 6,266,073 bp
  • A to G, chromosome 9 at 15,257,794 bp
  • G to A, chromosome 9 at 19,783,731 bp
  • G to A, chromosome 9 at 36,867,882 bp
  • T to C, chromosome 9 at 38,062,001 bp
  • A to T, chromosome 9 at 99,394,484 bp
  • A to C, chromosome 9 at 108,421,510 bp
  • A to G, chromosome 10 at 78,183,006 bp
  • A to T, chromosome 11 at 58,970,428 bp
  • C to G, chromosome 11 at 70,970,921 bp
  • T to C, chromosome 11 at 82,981,904 bp
  • T to C, chromosome 12 at 44,598,490 bp
  • G to A, chromosome 13 at 11,742,011 bp
  • C to T, chromosome 13 at 38,023,326 bp
  • G to A, chromosome 13 at 67,517,899 bp
  • G to A, chromosome 14 at 16,432,085 bp
  • C to A, chromosome 14 at 51,989,296 bp
  • A to G, chromosome 15 at 80,368,671 bp
  • A to T, chromosome 15 at 98,652,018 bp
  • G to A, chromosome 15 at 99,101,734 bp
  • T to C, chromosome 15 at 99,941,653 bp
  • A to T, chromosome 16 at 32,843,193 bp
  • A to T, chromosome 16 at 35,948,007 bp
  • T to A, chromosome 17 at 24,887,511 bp
  • T to A, chromosome 18 at 37,145,230 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4950 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042547-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.