Strain Name:
C57BL/6J-MtgxR4956Btlr/Mmmh
Stock Number:
042553-MU
Citation ID:
RRID:MMRRC_042553-MU
Other Names:
R4956 (G1), C57BL/6J-MtgxR4956Btlr
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, N-CoR, 5730405M06Rik, Rxrip13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: NO, 2310005C01Rik, nNOS, bNOS, Nos-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Odc1
Name: ornithine decarboxylase, structural 1
Synonyms: ODC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18263
VEGA: 12
HGNC: HGNC:8109
Homologene: 1906
Fzd9
Name: frizzled class receptor 9
Synonyms: frizzled 9, mfz9, Fz9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14371
HGNC: HGNC:4047
Homologene: 2619
Enah
Name: ENAH actin regulator
Synonyms: Mena, Ndpp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13800
Homologene: 134005
Ppp1r37
Name: protein phosphatase 1, regulatory subunit 37
Synonyms: Lrrc68
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232947
Homologene: 17851
Pcif1
Name: phosphorylated CTD interacting factor 1
Synonyms: F730014I05Rik, 2310022K11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228866
Homologene: 11134
Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Synonyms: Tpl2, Cot, Cot/Tpl2, Tpl-2, c-COT
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26410
HGNC: HGNC:6860
Homologene: 3812
Usp5
Name: ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms: Ucht
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22225
Homologene: 55758
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: D5Wsu150e, Serca2a, SERCA2, 9530097L16Rik, SERCA2B, sarco/endoplasmic reticulum Ca2+-ATPase 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: Mcaf1, ATFa-associated Modulator, AM, 2610204M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54343
Homologene: 10051
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: 1110020K19Rik, Uhrf1bp1, F830021D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Brd1
Name: bromodomain containing 1
Synonyms: 1110059H06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223770
HGNC: HGNC:1102
Homologene: 40956
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Axin2
Name: axin 2
Synonyms: Conductin, Axil
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12006
HGNC: HGNC:904
Homologene: 3420
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
Ipo13
Name: importin 13
Synonyms: Imp13, Kap13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230673
Homologene: 40968
Ipo9
Name: importin 9
Synonyms: Imp9, 0710008K06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226432
Homologene: 5874
Rcn1
Name: reticulocalbin 1
Synonyms: Rcn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19672
HGNC: HGNC:9934
Homologene: 20637
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Hmg20a
Name: high mobility group 20A
Synonyms: 5730490E10Rik, Hmgxb1, 1200004E06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66867
VEGA: 9
HGNC: HGNC:5001
Homologene: 32399
Dcaf6
Name: DDB1 and CUL4 associated factor 6
Synonyms: NRIP, 1200006M05Rik, Iqwd1, PC326
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74106
Homologene: 10199
Wtap
Name: WT1 associating protein
Synonyms: 9430038B09Rik, 2810408K05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 60532
Homologene: 68422
Chst9
Name: carbohydrate sulfotransferase 9
Synonyms: GalNAc4ST-2, 5430438D01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71367
Homologene: 12861
Tspear
Name: thrombospondin type laminin G domain and EAR repeats
Synonyms: ORF65, C330046G03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 252974
HGNC: HGNC:1268
Homologene: 36972
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244234
Homologene: 133218
3110009E18Rik
Name: RIKEN cDNA 3110009E18 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73103
Homologene: 41754
Obp2b
Name: odorant binding protein 2B
Synonyms: OTTMUSG00000012631, Lcn14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 383678
Homologene: 135821
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78809
Homologene: 53527
Zpr1
Name: ZPR1 zinc finger
Synonyms: Zfp259, ZPR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22687
Homologene: 2900
Yipf2
Name: Yip1 domain family, member 2
Synonyms: 1300010K09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74766
VEGA: 9
Homologene: 23430
Shbg
Name: sex hormone binding globulin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20415
Homologene: 813
Afap1l2
Name: actin filament associated protein 1-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226250
Homologene: 13057
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly-49Q, Ly49Q, Ly49q1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Cpn2
Name: carboxypeptidase N, polypeptide 2
Synonyms: 1300018K11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71756
VEGA: 16
HGNC: HGNC:2313
Homologene: 19487
Gadl1
Name: glutamate decarboxylase-like 1
Synonyms: 1110027M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73748
Homologene: 45812
Atxn7l3b
Name: ataxin 7-like 3B
Synonyms: 6230409E21Rik, 4921506J03Rik, ENSMUSG00000074747
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382423
Homologene: 115930
Tchp
Name: trichoplein, keratin filament binding
Synonyms: A930031F18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77832
Homologene: 12686
Zfp422-ps
Name: zinc finger protein 422, pseudogene
Synonyms: Zfp422-rs1, Krox-25-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100416808
Or5b97
Name: olfactory receptor family 5 subfamily B member 97
Synonyms: Olfr1447, GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258698
HGNC: HGNC:8324
Homologene: 74233
Or6c1
Name: olfactory receptor family 6 subfamily C member 1
Synonyms: MOR111-1, Olfr802, GA_x6K02T2PULF-11361362-11360424
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258934
HGNC: HGNC:8355
Homologene: 105151
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270151
VEGA: 9
Homologene: 11623
Or6ae1
Name: olfactory receptor family 6 subfamily AE member 1
Synonyms: Olfr522, MOR103-5, GA_x6K02T2PBJ9-42315125-42314187
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258954
Homologene: 62435
Ffar4
Name: free fatty acid receptor 4
Synonyms: Pgr4, Gpr129, Gpr120, O3far1, Ffa4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107221
VEGA: 19
Homologene: 18769
Vmn2r71
Name: vomeronasal 2, receptor 71
Synonyms: EG233445
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233445
Homologene: 115466
Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms: lysyl hydroxylase 3, LH3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26433
HGNC: HGNC:9083
Homologene: 843
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22784
Homologene: 74470
Vgll3
Name: vestigial like family member 3
Synonyms: Vito-2, 1700110N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73569
VEGA: 16
Homologene: 53442
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233060
Homologene: 32798
Plekhg2
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms: Clg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101497
Homologene: 16341
Or4c127
Name: olfactory receptor family 4 subfamily C member 127
Synonyms: GA_x6K02T2Q125-51434523-51435437, MOR234-1, Olfr1262
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258976
Homologene: 74064
Psmd6
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Synonyms: 2400006A19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66413
HGNC: HGNC:9564
Homologene: 7157
Or2t43
Name: olfactory receptor family 2 subfamily T member 43
Synonyms: Olfr327-ps1, GA_x6K02T00261-652-347, GA_x6K02T2NKPP-858022-858862, MOR275-10_p, Olfr224, MOR275-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258198
Homologene: 133015
Eif2s3y
Name: eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
Synonyms: Tfy, Eif-2gy, Spy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 26908
Homologene: 99414
A230020J21Rik
Name: RIKEN cDNA A230020J21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100125339
Esp38
Name: exocrine gland secreted peptide 38
Synonyms: Gm21946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126775
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 120,169,110 bp
  • G to T, chromosome 1 at 120,169,119 bp
  • C to T, chromosome 1 at 120,169,120 bp
  • A to G, chromosome 1 at 135,404,222 bp
  • A to T, chromosome 1 at 165,388,785 bp
  • G to A, chromosome 1 at 181,918,289 bp
  • A to G, chromosome 1 at 191,026,186 bp
  • A to G, chromosome 2 at 25,737,075 bp
  • G to A, chromosome 2 at 90,002,843 bp
  • A to T, chromosome 2 at 105,394,776 bp
  • A to T, chromosome 2 at 164,889,690 bp
  • G to A, chromosome 4 at 117,901,571 bp
  • G to A, chromosome 5 at 31,086,903 bp
  • A to C, chromosome 5 at 114,719,620 bp
  • A to G, chromosome 5 at 117,947,510 bp
  • A to G, chromosome 5 at 122,461,580 bp
  • G to A, chromosome 5 at 135,249,942 bp
  • A to G, chromosome 5 at 136,989,918 bp
  • G to A, chromosome 5 at 139,757,130 bp
  • C to G, chromosome 6 at 124,822,630 bp
  • A to G, chromosome 6 at 129,873,316 bp
  • C to T, chromosome 6 at 136,606,810 bp
  • A to T, chromosome 7 at 19,532,711 bp
  • A to C, chromosome 7 at 28,368,355 bp
  • T to A, chromosome 7 at 30,131,554 bp
  • C to T, chromosome 7 at 85,619,228 bp
  • A to G, chromosome 7 at 140,162,080 bp
  • A to G, chromosome 7 at 140,298,362 bp
  • T to G, chromosome 9 at 21,591,908 bp
  • T to A, chromosome 9 at 44,262,612 bp
  • C to T, chromosome 9 at 46,274,663 bp
  • T to C, chromosome 9 at 55,838,142 bp
  • A to G, chromosome 9 at 56,481,664 bp
  • T to A, chromosome 9 at 116,040,919 bp
  • A to G, chromosome 10 at 77,864,767 bp
  • A to G, chromosome 10 at 112,928,596 bp
  • A to G, chromosome 10 at 128,241,651 bp
  • A to T, chromosome 10 at 129,682,099 bp
  • A to G, chromosome 11 at 58,566,518 bp
  • T to A, chromosome 11 at 62,340,605 bp
  • C to T, chromosome 11 at 69,617,219 bp
  • T to C, chromosome 11 at 104,529,395 bp
  • T to C, chromosome 11 at 108,943,078 bp
  • T to C, chromosome 12 at 17,547,957 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • C to T, chromosome 14 at 14,116,166 bp
  • A to G, chromosome 14 at 103,287,239 bp
  • A to T, chromosome 15 at 88,730,113 bp
  • A to G, chromosome 16 at 4,854,952 bp
  • T to A, chromosome 16 at 30,260,415 bp
  • T to C, chromosome 16 at 65,827,934 bp
  • T to C, chromosome 17 at 12,967,536 bp
  • T to A, chromosome 17 at 27,889,984 bp
  • C to T, chromosome 17 at 33,305,235 bp
  • T to G, chromosome 17 at 39,955,162 bp
  • A to C, chromosome 18 at 4,339,530 bp
  • A to T, chromosome 18 at 15,717,988 bp
  • G to A, chromosome 18 at 37,957,705 bp
  • C to T, chromosome 19 at 12,901,599 bp
  • C to T, chromosome 19 at 38,097,580 bp
  • T to C, chromosome 19 at 56,943,447 bp
  • A to G, chromosome Y at 1,023,407 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4956 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042553-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.