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Strain Name:
C57BL/6J-MtgxR4963Btlr/Mmmh
Stock Number:
042560-MU
Citation ID:
RRID:MMRRC_042560-MU
Other Names:
R4963 (G1), C57BL/6J-MtgxR4963Btlr
Major Collection:

Strain Information

Dnajc3
Name: DnaJ heat shock protein family (Hsp40) member C3
Synonyms: p58IPK, mp58, Prkri, Dnajc3, Dnajc3a, Dnajc3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100037258
VEGA: 14
HGNC: HGNC:9439
Homologene: 2486
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: P19-PTP, PTP-PEST, PTP-P19
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Smc2
Name: structural maintenance of chromosomes 2
Synonyms: 5730502P04Rik, CAP-E, Fin16, Smc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14211
Homologene: 4705
Smarcc1
Name: SWI/SNF related BAF chromatin remodeling complex subunit C1
Synonyms: BAF155, SRG3, msp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20588
Homologene: 68296
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 43,992,268 bp
  • G to T, chromosome 1 at 75,505,627 bp
  • A to G, chromosome 1 at 90,939,390 bp
  • A to T, chromosome 1 at 189,882,188 bp
  • A to G, chromosome 2 at 25,661,414 bp
  • A to G, chromosome 2 at 76,753,945 bp
  • A to T, chromosome 2 at 83,925,110 bp
  • A to T, chromosome 2 at 150,408,495 bp
  • A to G, chromosome 2 at 150,939,909 bp
  • T to C, chromosome 3 at 96,163,250 bp
  • T to A, chromosome 3 at 113,153,441 bp
  • G to A, chromosome 3 at 127,032,096 bp
  • C to A, chromosome 4 at 32,756,512 bp
  • T to C, chromosome 4 at 52,450,826 bp
  • T to C, chromosome 4 at 96,316,382 bp
  • T to A, chromosome 5 at 3,609,924 bp
  • T to C, chromosome 5 at 14,669,221 bp
  • T to A, chromosome 5 at 21,015,708 bp
  • C to T, chromosome 5 at 33,160,782 bp
  • T to C, chromosome 5 at 35,047,255 bp
  • C to T, chromosome 5 at 37,322,049 bp
  • T to A, chromosome 5 at 73,678,993 bp
  • T to A, chromosome 5 at 115,450,885 bp
  • T to A, chromosome 5 at 120,141,566 bp
  • T to A, chromosome 5 at 122,422,606 bp
  • G to A, chromosome 6 at 23,049,584 bp
  • C to T, chromosome 6 at 112,816,732 bp
  • G to A, chromosome 6 at 116,386,271 bp
  • C to T, chromosome 6 at 125,667,483 bp
  • A to G, chromosome 6 at 141,923,099 bp
  • T to C, chromosome 7 at 24,994,626 bp
  • C to A, chromosome 7 at 30,450,801 bp
  • T to G, chromosome 7 at 35,403,152 bp
  • T to C, chromosome 7 at 120,360,919 bp
  • T to C, chromosome 7 at 123,308,360 bp
  • C to T, chromosome 8 at 21,201,758 bp
  • A to G, chromosome 8 at 47,065,461 bp
  • C to T, chromosome 8 at 61,703,210 bp
  • A to G, chromosome 8 at 71,889,788 bp
  • A to G, chromosome 8 at 77,555,729 bp
  • T to A, chromosome 8 at 87,048,006 bp
  • A to G, chromosome 8 at 104,482,318 bp
  • A to T, chromosome 9 at 44,103,264 bp
  • C to A, chromosome 9 at 103,320,605 bp
  • T to A, chromosome 9 at 110,213,745 bp
  • A to G, chromosome 10 at 79,746,551 bp
  • C to A, chromosome 10 at 92,695,031 bp
  • T to C, chromosome 11 at 46,682,790 bp
  • T to C, chromosome 11 at 66,084,611 bp
  • G to T, chromosome 11 at 67,757,593 bp
  • C to T, chromosome 11 at 75,382,294 bp
  • A to G, chromosome 11 at 82,904,937 bp
  • A to G, chromosome 11 at 89,050,802 bp
  • C to A, chromosome 11 at 100,752,253 bp
  • A to G, chromosome 12 at 79,188,606 bp
  • C to A, chromosome 13 at 8,985,217 bp
  • A to G, chromosome 13 at 21,537,982 bp
  • A to G, chromosome 13 at 23,819,407 bp
  • A to T, chromosome 13 at 30,540,763 bp
  • A to G, chromosome 13 at 38,197,870 bp
  • T to C, chromosome 13 at 58,328,994 bp
  • T to C, chromosome 13 at 72,632,610 bp
  • T to A, chromosome 14 at 34,147,016 bp
  • T to G, chromosome 14 at 34,566,858 bp
  • A to G, chromosome 14 at 47,268,689 bp
  • G to A, chromosome 14 at 69,190,918 bp
  • C to A, chromosome 14 at 118,978,173 bp
  • A to G, chromosome 15 at 11,036,281 bp
  • G to A, chromosome 15 at 44,504,025 bp
  • A to G, chromosome 15 at 63,804,380 bp
  • T to C, chromosome 16 at 58,465,782 bp
  • G to A, chromosome 17 at 6,198,813 bp
  • A to T, chromosome 17 at 20,375,141 bp
  • A to G, chromosome 17 at 36,671,738 bp
  • A to T, chromosome 17 at 48,163,414 bp
  • A to G, chromosome 17 at 75,538,982 bp
  • G to T, chromosome 17 at 84,660,141 bp
  • T to C, chromosome 18 at 4,375,638 bp
  • T to C, chromosome 18 at 47,298,251 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4963 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042560-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.