Strain Name:
C57BL/6J-MtgxR5063Btlr/Mmmh
Stock Number:
042653-MU
Citation ID:
RRID:MMRRC_042653-MU
Other Names:
R5063 (G1), C57BL/6J-MtgxR5063Btlr
Major Collection:

Gene Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Casp8
Name: caspase 8
Synonyms: Mch5, MACH, Caspase-8, FLICE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Slc21a7, Oatp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 108096
Homologene: 56603
Gtf2i
Name: general transcription factor II I
Synonyms: 6030441I21Rik, TFII-I, BAP-135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Sult6b1
Name: sulfotransferase family, cytosolic, 6B, member 1
Synonyms: 2410078J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 73671
Homologene: 42242
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, D14Ertd64e, 1500001N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 68059
Homologene: 21004
Armh3
Name: armadillo-like helical domain containing 3
Synonyms: 9130011E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 71617
VEGA: 19
Homologene: 15843
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, Diap3, Drf3, mDia2, 4930417P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56419
VEGA: 14
Homologene: 84829
Srebf2
Name: sterol regulatory element binding factor 2
Synonyms: lop13, bHLHd2, nuc, SREBP2, SREBP2gc, SREBP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20788
VEGA: 15
Homologene: 20966
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Mcpr, Apc1, 2610021O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17222
Homologene: 7414
Rpl7a
Name: ribosomal protein L7A
Synonyms: surfeit 3, Surf-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27176
Homologene: 105462
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21745
VEGA: 14
Homologene: 5157
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2A-HUB, 2310047C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224170
Homologene: 8771
Chn2
Name: chimerin 2
Synonyms: 4930557O16Rik, 1700026N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Cenpe
Name: centromere protein E
Synonyms: CENP-E, 312kDa, Kif10, N-7 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Ptov1
Name: prostate tumor over expressed gene 1
Synonyms: 1110030G05Rik, Gcap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 84113
HGNC: HGNC:9632
Homologene: 9687
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, tf, Itpr-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 104271
Homologene: 12837
Olfr720
Name: olfactory receptor 720
Synonyms: MOR274-2, GA_x6K02T2PLTE-6544896-6543946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258387
Homologene: 74036
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: C79217, Cav1.3alpha1, 8430418G19Rik, Cchl1a2, Cacnl1a2, D-LTCC, Cchl1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Psmc1
Name: protease (prosome, macropain) 26S subunit, ATPase 1
Synonyms: rpt2, Rpt2/S4, P26s4, S4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 19179
VEGA: 12
HGNC: HGNC:9547
Homologene: 2095
Klf17
Name: Kruppel-like factor 17
Synonyms: Zfp393, 7420700M05Rik, D4Ertd561e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75753
Homologene: 12621
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 546981
Homologene: 115466
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 669149
Homologene: 129606
Slc25a45
Name: solute carrier family 25, member 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107375
Homologene: 76679
Iqcm
Name: IQ motif containing M
Synonyms: 1700007B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71831
Homologene: 53050
Tmem175
Name: transmembrane protein 175
Synonyms: 3010001K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72392
Homologene: 12461
Letm2
Name: leucine zipper-EF-hand containing transmembrane protein 2
Synonyms: D030041N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270035
Homologene: 56358
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 625029
Homologene: 83669
Arhgef4
Name: Rho guanine nucleotide exchange factor (GEF) 4
Synonyms: Asef, C230030N03Rik, 9330140K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Padi6
Name: peptidyl arginine deiminase, type VI
Synonyms: Padi5, ePAD, Pad6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242726
Homologene: 17695
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381122
VEGA: 17
Homologene: 27026
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 435845
Homologene: 78847
Msh5
Name: mutS homolog 5
Synonyms: Mut5, G7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Zmat4
Name: zinc finger, matrin type 4
Synonyms: 9630048M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 320158
Homologene: 81899
Chst12
Name: carbohydrate sulfotransferase 12
Synonyms: C4S-2, C4ST-2, C4ST2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59031
Homologene: 69258
Dzip1l
Name: DAZ interacting protein 1-like
Synonyms: 2610524A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 72507
Homologene: 12466
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1163.1Clo, b2b1291.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329795
Homologene: 71886
Lrrc31
Name: leucine rich repeat containing 31
Synonyms: E230002P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 320352
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219094
VEGA: 14
Homologene: 23611
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: activated p21cdc42Hs kinase, ACK1, P21cdc42Hs kinase, Pyk1, Ack
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 51789
Homologene: 4224
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69387
Homologene: 70141
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 236573
Homologene: 128731
Olfr16
Name: olfactory receptor 16
Synonyms: MOR267-13, MOR23, GA_x6K02T2R7CC-893157-892228
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18313
Homologene: 7460
Kcnip4
Name: Kv channel interacting protein 4
Synonyms: Calp250, KChIP4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 80334
Homologene: 23528
St6galnac5
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Synonyms: ST6GalNAc V, Siat7e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26938
Homologene: 8079
Zdhhc4
Name: zinc finger, DHHC domain containing 4
Synonyms: 2900029I10Rik, 1810021D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72881
Homologene: 10006
AC104930.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 545848
Ppy
Name: pancreatic polypeptide
Synonyms: IGSPP, PP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19064
HGNC: HGNC:9327
Homologene: 2039
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,724,215 bp
  • A to T, chromosome 1 at 58,844,374 bp
  • T to A, chromosome 1 at 172,957,442 bp
  • T to A, chromosome 2 at 26,910,994 bp
  • G to A, chromosome 2 at 52,223,212 bp
  • C to T, chromosome 2 at 113,364,921 bp
  • T to C, chromosome 2 at 128,629,549 bp
  • C to A, chromosome 3 at 19,989,215 bp
  • A to G, chromosome 3 at 30,689,936 bp
  • T to A, chromosome 3 at 135,270,954 bp
  • T to C, chromosome 3 at 152,981,135 bp
  • A to T, chromosome 4 at 12,079,840 bp
  • A to G, chromosome 4 at 117,760,659 bp
  • T to C, chromosome 4 at 140,741,880 bp
  • G to A, chromosome 5 at 48,482,579 bp
  • T to C, chromosome 5 at 86,237,830 bp
  • T to C, chromosome 5 at 105,085,162 bp
  • T to C, chromosome 5 at 108,646,432 bp
  • T to A, chromosome 5 at 134,260,571 bp
  • G to T, chromosome 5 at 140,524,412 bp
  • T to A, chromosome 5 at 143,316,622 bp
  • A to T, chromosome 6 at 54,290,287 bp
  • C to T, chromosome 6 at 58,855,760 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • G to A, chromosome 6 at 142,259,065 bp
  • A to G, chromosome 7 at 44,865,602 bp
  • T to A, chromosome 7 at 86,164,164 bp
  • T to G, chromosome 7 at 100,510,823 bp
  • C to A, chromosome 7 at 112,954,424 bp
  • A to T, chromosome 8 at 23,748,441 bp
  • T to C, chromosome 8 at 25,581,779 bp
  • T to G, chromosome 8 at 33,582,610 bp
  • A to T, chromosome 8 at 75,746,286 bp
  • A to G, chromosome 9 at 99,667,652 bp
  • A to C, chromosome 10 at 79,479,087 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 102,100,699 bp
  • T to C, chromosome 11 at 120,010,489 bp
  • T to C, chromosome 12 at 100,115,475 bp
  • A to T, chromosome 14 at 14,175,593 bp
  • A to G, chromosome 14 at 30,051,383 bp
  • A to T, chromosome 14 at 50,850,627 bp
  • A to G, chromosome 14 at 51,411,146 bp
  • A to T, chromosome 14 at 55,887,203 bp
  • A to T, chromosome 14 at 86,984,870 bp
  • T to A, chromosome 14 at 122,145,146 bp
  • A to G, chromosome 15 at 6,836,897 bp
  • T to C, chromosome 15 at 82,177,451 bp
  • T to A, chromosome 16 at 32,670,850 bp
  • T to A, chromosome 16 at 48,953,754 bp
  • A to T, chromosome 17 at 27,089,911 bp
  • A to T, chromosome 17 at 35,042,188 bp
  • T to A, chromosome 17 at 73,322,079 bp
  • A to T, chromosome 17 at 78,905,576 bp
  • G to T, chromosome 18 at 37,519,126 bp
  • T to C, chromosome 19 at 5,884,462 bp
  • A to G, chromosome 19 at 45,885,955 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5063 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042653-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.