Strain Name:
C57BL/6J-MtgxR5077Btlr/Mmmh
Stock Number:
042666-MU
Citation ID:
RRID:MMRRC_042666-MU
Other Names:
R5077 (G1), C57BL/6J-MtgxR5077Btlr
Major Collection:

Gene Information

Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: PTPzeta, Rptpbeta, RPTPz, PTPbeta, Ptprz, phosphacan, DSD-1-PG, Ptpz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: Dlgh4, SAP90A, PSD-95, SAP90, PSD95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Prdm5
Name: PR domain containing 5
Synonyms: PFM2, E130112L17Rik, 6530401I24Rik, 4432417F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Szrd1
Name: SUZ RNA binding domain containing 1
Synonyms: D4Ertd22e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213491
Homologene: 9213
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Zc3h14
Name: zinc finger CCCH type containing 14
Synonyms: 2700069A02Rik, 1010001P15Rik, 1700016A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75553
VEGA: 12
Homologene: 32605
Nckap1
Name: NCK-associated protein 1
Synonyms: Hem2, Nap1, mh19, Hem-2, H19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Resf1
Name: retroelement silencing factor 1
Synonyms: GET, 2810474O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67246
Homologene: 19251
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: 4833422K13Rik, C330023M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231713
Homologene: 6891
Cdca8
Name: cell division cycle associated 8
Synonyms: 4831429J16Rik, Borealin, DasraB, D4Ertd421e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52276
Homologene: 23075
Rbck1
Name: RanBP-type and C3HC4-type zinc finger containing 1
Synonyms: HOIL-1L, HOIL-1, Ubce7ip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24105
Homologene: 32448
Psen1
Name: presenilin 1
Synonyms: PS1, presenilin-1, PS-1, S182, Ad3h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19164
VEGA: 12
HGNC: HGNC:9508
Homologene: 7186
Insig2
Name: insulin induced gene 2
Synonyms: Insig-2, C730043J18Rik, 2900053I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72999
Homologene: 9400
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217337
Homologene: 7056
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Dbx1
Name: developing brain homeobox 1
Synonyms: Mmox C, Dbx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13172
Homologene: 19002
Efl1
Name: elongation factor like GTPase 1
Synonyms: 4932434J20Rik, D7Ertd791e, 6030468D11Rik, Eftud1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101592
Homologene: 11599
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: 4932415L06Rik, C330008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319651
Homologene: 10858
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Slc35f5
Name: solute carrier family 35, member F5
Synonyms: 1300003P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74150
Homologene: 5745
Pram1
Name: PML-RAR alpha-regulated adaptor molecule 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 378460
Homologene: 12963
Myo16
Name: myosin XVI
Synonyms: C230040D10Rik, Nyap3, BM140241
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244281
Homologene: 34710
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: DMPK-like, A930014J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Catsper1
Name: cation channel, sperm associated 1
Synonyms: KSper
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225865
VEGA: 19
Homologene: 14207
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, Cmya3, 2310003D02Rik, myomaxin, mXin beta, 2310008C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Gm10800
Name: predicted gene 10800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Dlgap2
Name: DLG associated protein 2
Synonyms: PSD-95/SAP90-binding protein 2, 6430596N04Rik, Sapap2, DAP2, SAP90/PSD-95-associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, heco, A930030P13Rik, 1110008N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20663
Homologene: 38253
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224572
Homologene: 115024
Nrp1
Name: neuropilin 1
Synonyms: NPN-1, Neuropilin-1, Npn1, NP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214804
Homologene: 19035
Capn2
Name: calpain 2
Synonyms: Capa-2, Capa2, m-calpain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212892
Homologene: 71779
Nsun4
Name: NOL1/NOP2/Sun domain family, member 4
Synonyms: 2310010O12Rik, 2810405F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72181
Homologene: 12455
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cchra1, Cav2.3, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Olfr1055
Name: olfactory receptor 1055
Synonyms: GA_x6K02T2Q125-47819205-47818258, MOR186-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259023
Homologene: 131140
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: Wdr67, LOC210544, D330013L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210544
Homologene: 17089
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 63913
Homologene: 62170
Kcnip3
Name: Kv channel interacting protein 3, calsenilin
Synonyms: Csen, KChIP3, R74849, DREAM, 4933407H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56461
Homologene: 8382
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: Ccp6, 4931433A01Rik, 4930578N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 78933
Homologene: 84880
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171200
Homologene: 134034
Rmnd1
Name: required for meiotic nuclear division 1 homolog
Synonyms: 0610042C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66084
Homologene: 5675
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semaf, Semacl1, Semai, M-Sema F, Semacl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20353
Homologene: 23047
Tmprss11d
Name: transmembrane protease, serine 11d
Synonyms: AsP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231382
Homologene: 74519
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
H4f16
Name: H4 histone 16
Synonyms: H4-16, B130044J01Rik, Hist4h4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320332
Homologene: 134493
Gm11534
Name: predicted gene 11534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
RP23-62L19.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,551,731 bp
  • A to G, chromosome 1 at 74,441,561 bp
  • A to T, chromosome 1 at 121,312,235 bp
  • A to G, chromosome 1 at 125,589,852 bp
  • A to G, chromosome 1 at 151,714,523 bp
  • A to T, chromosome 1 at 154,561,729 bp
  • A to T, chromosome 1 at 180,094,533 bp
  • G to T, chromosome 1 at 182,472,573 bp
  • A to C, chromosome 2 at 67,514,477 bp
  • A to T, chromosome 2 at 80,548,933 bp
  • A to T, chromosome 2 at 86,347,339 bp
  • A to T, chromosome 2 at 98,667,034 bp
  • A to G, chromosome 2 at 127,465,877 bp
  • A to C, chromosome 2 at 152,318,451 bp
  • G to T, chromosome 3 at 146,002,009 bp
  • A to T, chromosome 4 at 111,566,742 bp
  • A to T, chromosome 4 at 116,048,584 bp
  • A to T, chromosome 4 at 118,369,616 bp
  • T to C, chromosome 4 at 124,926,677 bp
  • G to T, chromosome 4 at 141,139,781 bp
  • C to T, chromosome 4 at 145,088,241 bp
  • C to A, chromosome 5 at 86,309,263 bp
  • G to A, chromosome 5 at 121,424,576 bp
  • T to C, chromosome 6 at 22,987,375 bp
  • T to C, chromosome 6 at 57,405,041 bp
  • C to A, chromosome 6 at 65,779,174 bp
  • A to G, chromosome 6 at 136,804,115 bp
  • T to G, chromosome 6 at 149,326,030 bp
  • A to G, chromosome 7 at 49,633,494 bp
  • C to A, chromosome 7 at 82,658,087 bp
  • T to C, chromosome 8 at 10,322,658 bp
  • T to G, chromosome 8 at 14,822,691 bp
  • A to G, chromosome 8 at 43,627,163 bp
  • G to T, chromosome 8 at 128,500,673 bp
  • A to G, chromosome 9 at 109,441,049 bp
  • T to C, chromosome 10 at 4,427,488 bp
  • A to G, chromosome 10 at 33,908,279 bp
  • G to T, chromosome 11 at 59,044,057 bp
  • A to G, chromosome 11 at 70,027,026 bp
  • T to A, chromosome 11 at 95,876,314 bp
  • T to C, chromosome 11 at 116,245,812 bp
  • T to C, chromosome 12 at 69,585,204 bp
  • C to T, chromosome 12 at 70,201,892 bp
  • T to C, chromosome 12 at 81,734,077 bp
  • T to C, chromosome 12 at 83,724,665 bp
  • T to A, chromosome 12 at 98,757,206 bp
  • T to A, chromosome 12 at 108,506,612 bp
  • A to G, chromosome 13 at 112,355,988 bp
  • A to T, chromosome 15 at 6,844,393 bp
  • A to G, chromosome 15 at 57,955,401 bp
  • A to C, chromosome 15 at 64,127,423 bp
  • T to C, chromosome 17 at 19,677,572 bp
  • T to C, chromosome 17 at 25,375,250 bp
  • C to T, chromosome 17 at 33,644,904 bp
  • A to G, chromosome 19 at 5,335,970 bp
  • T to C, chromosome 19 at 42,119,836 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5077 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042666-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.